Abstract：
:Elevated uric acid levels have recently been found to be associated with slower disease progression in Parkinson's disease, Huntington's disease, multiple system atrophy, and mild cognitive impairment. The aim of this study is to determine whether serum uric acid levels predict survival in amyotrophic lateral sclerosis (ALS). A total of 251 people with ALS enrolled in two multicenter clinical trials were included in our analysis. The main outcome measure was survival time, which was calculated as time to death, tracheostomy, or permanent assistive ventilation, with any event considered a survival endpoint. Cox proportional hazards models were used to estimate the hazard ratio (HR) of reaching a survival endpoint according to baseline uric acid levels after adjusting for markers of disease severity (FVC, total ALSFRS-R score, time since symptom onset, diagnostic delay, BMI, bulbar vs. spinal onset, age, and riluzole use). There was a dose-dependent survival advantage in men, but not women, with higher baseline uric acid levels (logrank test: p = 0.018 for men, p = 0.81 for women). There was a 39% reduction in risk of death during the study for men with each 1 mg/dl increase in uric acid levels (adjusted HR: 0.61, 95% CI 0.39-0.96, p = 0.03). This is the first study to demonstrate that serum uric acid is associated with prolonged survival in ALS, after adjusting for markers of disease severity. Similar to previous reports in Parkinson's disease, this association was seen in male subjects only.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Paganoni S,Zhang M,Quiroz Zárate A,Jaffa M,Yu H,Cudkowicz ME,Wills AMdoi
10.1007/s00415-012-6440-7subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1923-8issue
9eissn
0340-5354issn
1432-1459journal_volume
259pub_type
杂志文章,多中心研究abstract：OBJECTIVES:Resistance to activated protein C (APC) is the most frequent cause of thrombophilia and a well known risk factor for deep and cerebral vein thrombosis. Its causative role in ischaemic stroke is still a matter of debate. We undertook this study to determine the prevalence of APC-resistance in a cohort of cons...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150170117
更新日期：2001-08-01 00:00:00
abstract：:Small fibre neuropathy (SFN) has been demonstrated in sarcoidosis. However, a systematic analysis of neuropathic pain and autonomic symptoms, key features of SFN, has not been performed. Clinimetric evaluation of pain and autonomic symptoms using the neuropathic pain scale (NPS) and the modified Composite Autonomic Sy...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5664-7
更新日期：2010-12-01 00:00:00
abstract：:Ten female patients suffering from catamenial epilepsy were treated with a synthetic analogue of the gonadotrophin releasing hormone (GnRH) in addition to antiepileptic drugs. Three of the patients became seizure free, in four patients seizure frequency decreased and in one patient seizures were of shorter duration. I...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00810354
更新日期：1992-05-01 00:00:00
abstract：:Post-concussion symptoms (PCS) (such as headaches, irritability, anxiety, dizziness, fatigue and impaired concentration) are frequently experienced by patients who have sustained a minor head injury (MHI). The post-concussion syndrome has been defined as a clinical state where 3 or more symptoms persist for more than ...
journal_title：Journal of neurology
pub_type： 临床试验,杂志文章
doi：10.1007/s004150050254
更新日期：1998-09-01 00:00:00
abstract：:Vanishing white matter disease (VWM) is one of the most prevalent inherited leukoencephalopathies in childhood. Infantile VWM is more severe but less understood than the classic early childhood type. We performed a follow-up study on 14 infantile and 26 childhood patients to delineate the natural history and neuroimag...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-018-8851-6
更新日期：2018-06-01 00:00:00
abstract：:PNPLA6 mutations, known to be associated with the development of motor neuron phenotypes, have recently been identified in families with Boucher-Neuhäuser syndrome. Boucher-Neuhäuser is a rare autosomal recessive syndrome characterized by the co-occurrence of cerebellar ataxia, hypogonadotropic hypogonadism, and chori...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7516-3
更新日期：2014-12-01 00:00:00
abstract：:The similar localization of intracranial calcification in hypoparathyroidism and in Fahr disease without parathyroid gland disorder suggests that in these two disorders the pathomechanism of calcium phosphate deposition in the brain may be similar. It may be that in Fahr disease some factors, such as chronic respirato...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF00314315
更新日期：1988-01-01 00:00:00
abstract：:The International Cooperative Ataxia Rating Scale (ICARS) is a 100-point semiquantitative scale designed primarily to assess cerebellar dysfunction. However, little is known of the metric properties of this scale. We assessed the ICARS by rating the severity of cerebellar dysfunction in 27 patients with spinocerebella...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-006-0310-0
更新日期：2007-06-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-004-0351-1
更新日期：2004-04-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/BF02444004
更新日期：1996-02-01 00:00:00
abstract：:Despite the fact that almost one-third of patients suffer from visual deficits following brain damage; neuro-visual rehabilitation to compensate for visual field deficits is relatively neglected in the clinical setting. This is in contrast to physio and speech therapies, which are the bread and butter of rehabilitativ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-016-8291-0
更新日期：2017-06-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-020-09782-8
更新日期：2020-07-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-018-9013-6
更新日期：2018-11-01 00:00:00
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journal_title：Journal of neurology
pub_type： 信件
doi：10.1007/s00415-009-5148-9
更新日期：2009-09-01 00:00:00
abstract：:Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-009-5403-0
更新日期：2010-05-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-010-5578-4
更新日期：2010-10-01 00:00:00
abstract：:Focal transcranial magnetic stimulation (TMS) of the motor cortex was used to study excitatory and inhibitory stimulation effects in 25 patients with writer's cramp and 25 healthy volunteers. We investigated excitatory and inhibitory corticospinally mediated motor effects in muscles contralateral to the stimulation si...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s004150170269
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:There exist controversial and discrepant results on the risk of spontaneous abortions and teratogenesis induced by interferon treatment in people with MS.Aim of this study is to evaluate risks of the administration of INFbeta related not only to the foetus, but also to children development up to 12-months dev...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0909-4
更新日期：2008-08-01 00:00:00
abstract：: ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-019-09192-5
更新日期：2019-03-01 00:00:00
abstract：:Alexander disease (AD) is a rare genetic disorder of the central nervous system due to a dysfunction of astrocytes. The most common infantile form presents as a progressive leukodystrophy with macrocephalus. Recently, heterozygous de novo mutations in the gene encoding glial fibrillary acidic protein (GFAP) have been ...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-003-0995-2
更新日期：2003-03-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-008-0019-3
更新日期：2008-11-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-016-8162-8
更新日期：2016-08-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00415-014-7283-1
更新日期：2014-05-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-014-7524-3
更新日期：2015-01-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-017-8485-0
更新日期：2017-06-01 00:00:00
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journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-006-0092-4
更新日期：2006-07-01 00:00:00
abstract：:Atrial fibrillation (AF) is considered a predictor for severe stroke and poor outcome. The aim was to evaluate whether AF is associated with poor outcome in acute ischemic stroke (IS) patients treated with intravenous thrombolysis (IVT). In a retrospective study, 157 consecutive IS patients (98 males, mean age 67.3 +/...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5452-4
更新日期：2010-06-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) of hand movements in amyotrophic lateral sclerosis (ALS) has repeatedly demonstrated increased activation in cortical and subcortical areas, whereas a single study has suggested decreased rather than increased activations for tongue movements in patients with bulbar involve...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-010-5842-7
更新日期：2011-05-01 00:00:00
abstract：:Currently, several disease-modifying therapies for the treatment of multiple sclerosis are established and more are likely to be introduced. These treatment options differ with respect to their application profile, mechanism of action, efficacy, safety, and tolerance. Here, we review current concepts of MS therapies, ...
journal_title：Journal of neurology
pub_type： 杂志文章,评审
doi：10.1007/s00415-011-6101-2
更新日期：2011-10-01 00:00:00
abstract：:Neuropsychological assessment is one of the main fields of activity of clinical neuropsychologists. Goals of this assessment are verification and description of cognitive and affective impairments as the consequence of brain damage. Included are examinations of basal and higher sensory functions, the intellectual prof...
journal_title：Journal of neurology
pub_type： 杂志文章
doi：10.1007/s00415-007-2004-7
更新日期：2007-05-01 00:00:00
