Abstract:
:Each human has approximately 50 to 280 frameshifting indels, yet their implications are unknown. We created SIFT Indel, a prediction method for frameshifting indels that has 84% accuracy. The percentage of human frameshifting indels predicted to be gene-damaging is negatively correlated with allele frequency. We also show that although the first frameshifting indel in a gene causes loss of function, there is a tendency for the second frameshifting indel to compensate and restore protein function. SIFT Indel is available at http://sift-dna.org/www/SIFT_indels2.html.
journal_name
Genome Bioljournal_title
Genome biologyauthors
Hu J,Ng PCdoi
10.1186/gb-2012-13-2-r9subject
Has Abstractpub_date
2012-02-09 00:00:00pages
R9issue
2eissn
1474-7596issn
1474-760Xpii
gb-2012-13-2-r9journal_volume
13pub_type
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