Abstract：
OBJECTIVE:To evaluate the effect of a continuous infusion of basic fibroblast growth factor on the adaptive potential of the right ventricular myocardium after 30 days of mechanically induced overload in rats. Materials and methods We banded the pulmonary trunk, so as to increase the systolic workload of the right ventricle, in six Lewis/HanHsd rats at the age of 11 weeks, using six adult rats as controls. The six adult rats were also banded and received an additional continuous infusion of basic fibroblastic growth factor, using six rats with a continuous infusion of basic fibroblastic growth factor only as controls. We analysed the functional adaptation and structural changes of the right ventricular myocardium, blood vessels, and interstitial tissue 30 days after the increased afterload. RESULTS:The pulmonary artery banding induced an increase in the right ventricular free wall thickness of banded rats when compared with controls, which was mainly justified by an increase in cardiomyocyte area and in the percentage of extracellular fibrosis. The infusion of basic fibroblastic growth factor promotes a more extensive capillary network in banded rats (p < 0.001), which modulates the compensatory response of the right ventricle, promoting the hypertrophy of contractile elements and limiting the areas in which fibrosis develops (p < 0.001). CONCLUSIONS:The subcutaneous infusion with osmotic pumps was a valid and reproducible method of delivering basic fibroblast growth factor to heart tissue. This infusion contributed to better preserve the right ventricular capillary network, hampering the development of interstitial fibrosis.
journal_name
Cardiol Youngjournal_title
Cardiology in the youngauthors
Vida VL,Dedja A,Faggin E,Speggiorin S,Padalino MA,Boccuzzo G,Pauletto P,Angelini A,Milanesi O,Thiene G,Stellin Gdoi
10.1017/S1047951111002034subject
Has Abstractpub_date
2012-08-01 00:00:00pages
436-42issue
4eissn
1047-9511issn
1467-1107pii
S1047951111002034journal_volume
22pub_type
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