Abstract:
:Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.
journal_name
Curr Vasc Pharmacoljournal_title
Current vascular pharmacologyauthors
Uemura M,Kasahara Y,Nagatsuka K,Taguchi Adoi
10.2174/157016112799959369subject
Has Abstractpub_date
2012-05-01 00:00:00pages
285-8issue
3eissn
1570-1611issn
1875-6212pii
CVP-EPUB-20120113-006journal_volume
10pub_type
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