当前位置： SCI文献检索 > MEDICINE期刊下所有文献 > Spectrum of cardiac lesions in Behçet disease: a series of 52 patients and review of the literature.

Spectrum of cardiac lesions in Behçet disease: a series of 52 patients and review of the literature.

Abstract：

:Cardiac abnormalities in patients with Behçet disease (BD) include pericarditis, myocarditis, endocarditis with valvular regurgitation, intracardiac thrombosis, endomyocardial fibrosis, coronary arteritis with or without myocardial infarction, and aneurysms of the coronary arteries or sinus of Valsalva. Data regarding the clinical spectrum, prevalence, and outcome of cardiac lesions in BD are lacking. In this study, we report the main characteristics, treatment, and long-term outcomes of 52 patients with cardiac lesions from a cohort of 807 (6%) BD patients. Forty-five (86.5%) patients were male, with a mean (±SD) age at BD diagnosis of 29.3 ± 10.3 years.Cardiac involvement was the first feature of BD in 17 (32.7%) patients. Cardiac lesions included pericarditis (n = 20; 38.5%), endocarditis (mostly aortic insufficiency) (n = 14; 26.9%), intracardiac thrombosis (n = 10; 19.2%), myocardial infarction (n = 9; 17.3%), endomyocardial fibrosis (n = 4; 7.7%) and myocardial aneurysm (n = 1; 1.9%). Patients with cardiac involvement were more frequently male (86.5% vs. 64.9%; p < 0.01) and had more arterial (42.3% vs. 11.1%; p < 0.01) and venous lesions (59.6% vs. 35.8%; p < 0.01) compared to those without cardiac manifestations. Factors associated with complete remission of cardiac involvement were treatment regimens with oral anticoagulants, immunosuppressants, and colchicine. The 5-year survival rate was 83.6% and 95.8% (p = 0.03) in BD patients with and without cardiac involvement, respectively. After a median (Q1-Q3) follow-up of 3.0 (1.75-4.2) years, 8 patients had died, in 3 cases directly related to cardiac involvement.In conclusion, cardiac lesions affected 6% of our large cohort of BD patients. The prognosis of cardiac involvement in BD is poor and improves with oral anticoagulation, immunosuppressive therapy, and colchicine.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Geri G,Wechsler B,Thi Huong DL,Isnard R,Piette JC,Amoura Z,Resche-Rigon M,Cacoub P,Saadoun D

doi

10.1097/MD.0b013e3182428f49

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

25-34

issue

eissn

0025-7974

issn

1536-5964

pii

00005792-201201000-00004

journal_volume

pub_type

杂志文章,评审

在线工具

Spectrum of cardiac lesions in Behçet disease: a series of 52 patients and review of the literature.