Abstract：
:The phosphoinositide 3-kinase/Akt1 signaling pathway has emerged as a target for cancer therapy. In this study, we aimed to develop a strategy to enhance Akt-targeted cancer therapy. We hypothesized that combination of Akt1-targeted therapy with conventional chemotherapy using paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel may have synergistic effects in cancer therapeutic efficiency compared with chemotherapy alone. In this study, we found that the combination of shAkt1 with paclitaxel exerted synergistic anti-cancer effects, thus, inhibiting the growth of human breast cancer cells, and breast cancer xenografts in mice as well. The combination therapy demonstrated enhanced anti-cancer effects through inhibiting Akt1 signaling and inducing apoptosis. Our results suggest that the presented strategy of combination of shAkt1 with paclitaxel may have a potential for treatment of breast cancer.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Guo DD,Hong SH,Jiang HL,Kim JH,Minai-Tehrani A,Kim JE,Shin JY,Jiang T,Kim YK,Choi YJ,Cho CS,Cho MHdoi
10.1016/j.biomaterials.2011.12.011subject
Has Abstractpub_date
2012-03-01 00:00:00pages
2272-81issue
7eissn
0142-9612issn
1878-5905pii
S0142-9612(11)01466-9journal_volume
33pub_type
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