Abstract：
RATIONALE AND OBJECTIVES:To evaluate cone beam computed tomography (CBCT) for monitoring of tibial bone defect healing in comparison to histopathological findings. MATERIALS AND METHODS:Circumscribed tibial bone defects were created in 16 mini-pigs and imaging of the tibia was performed on day 42 using a modern CBCT scanner with flat panel detector (PaX-Duo3D, Vatech, Korea). The extent of osseous consolidation including remaining calcium phosphate granules was measured quantitatively by a CBCT volumetry tool using commercially available software (Osirix Imaging software, Pixmeo, Geneva, Switzerland). Volumes of the entire defect (including all pixels), areas of osseous consolidation (density values >2350) and nonmineralized areas (density values <2350) of the defect were determined. The extent of bone regeneration was determined and correlated with the histomorphometrical reference standard. Independently, a visual semiquantitative CBCT-score was applied (4-point scale) to assess bone defect healing. RESULTS:The extent of osseous consolidation in CBCT volumetry ranged from 14% to 92% (mean, 63.4 ± 17.6%). There was a significant positive correlation between histologically visible newly formed bone and the extent of bone regeneration on CBCT volumetry (r = 0.74-0.79, P < .001). The visual score matched with the volumetric results in 75% of the cases. CONCLUSION:CBCT volumetry allows for reliable, noninvasive quantitative monitoring of bone defect healing and correlates significantly with histological findings. CBCT is a promising technique for imaging of peripheral bones suggesting further evaluation in clinical trials.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Kröpil P,Hakimi AR,Jungbluth P,Riegger C,Rubbert C,Miese F,Lanzman RS,Wild M,Schek A,Scherer A,Windolf J,Antoch G,Becker J,Hakimi Mdoi
10.1016/j.acra.2011.10.022subject
Has Abstractpub_date
2012-03-01 00:00:00pages
320-5issue
3eissn
1076-6332issn
1878-4046pii
S1076-6332(11)00509-5journal_volume
19pub_type
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