Abstract:
:Astragalin (kaempferol-3-O-β-D-glucopyranoside, Ast) glucosides were synthesized by the acceptor reaction of a dextransucrase produced by Leuconostoc mesenteroides B-512FMCM with astragalin and sucrose. Each glucoside was purified and their structures were assigned as kaempferol-3-O-β-D-glucopyranosyl-(1→3)-O-α-D-glucopyranoside (or kaempferol-3-O-β-D-nigeroside, Ast-G1') and kaempferol-3-O-β-D-glucopyranosyl-(1→6)-O-α-D-glucopyranoside (or kaempferol-3-O-β-D-isomaltoside, Ast-G1) for one glucose transferred, and kaempferol-3-O-β-D-isomaltooligosacharide (Ast-IMO or Ast-Gn; n=2-8). The astragalin glucosides exhibited 8.3-60.6% higher inhibitory effects on matrix metalloproteinase-1 expression, 18.8-20.3% increased antioxidant effects, and 3.8-18.8% increased inhibition activity of melanin synthesis compared to control (without the addition of compound), depending on the number of glucosyl residues linked to astragalin. These novel compounds could be used to further expand the industrial applications of astragalin glucosides, in particular in the cosmetics industry.
journal_name
Enzyme Microb Technoljournal_title
Enzyme and microbial technologyauthors
Kim GE,Kang HK,Seo ES,Jung SH,Park JS,Kim DH,Kim DW,Ahn SA,Sunwoo C,Kim Ddoi
10.1016/j.enzmictec.2011.09.007subject
Has Abstractpub_date
2012-01-05 00:00:00pages
50-6issue
1eissn
0141-0229issn
1879-0909pii
S0141-0229(11)00196-7journal_volume
50pub_type
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