Immunological alterations used to predict infections in response to strenuous physical training.

Abstract:

:The aim of this study was to screen leukocyte cell surface markers to identify possible predictors for infection related to physical training. Ten healthy soldiers (mean age, 19.1; mean body mass, 77.4 kg; mean VO2 peak, 4.54 L min(-1)/58.6 mL min(-1) kg(-1)) were included. Blood samples were collected and number of infections recorded before and after a 6-day training course. White blood cell distributions and expression of surface receptors changed during training. Before training, expression of CD3 on CD8+ lymphocytes and percent CD8+CD3 lymphocytes was lower, whereas CD4/CD8 ratio was higher among subjects who failed compared to those who completed the training. A subclinical infection before the start of the military training may alter the CD4/CD8 ratio. Prediction of future infections may be possible from pre-exercise immunological status, findings useful in military settings and exercise, where sudden infections may result in severe consequences.

journal_name

Mil Med

journal_title

Military medicine

authors

Ekblom O,Ekblom B,Malm C

doi

10.7205/milmed-d-10-00427

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

785-90

issue

7

eissn

0026-4075

issn

1930-613X

journal_volume

176

pub_type

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