Abstract:
:In Saccharomyces cerevisiae, the cell integrity pathway plays a role in the oxidative stress response. In this study, we show that the Pkc1 protein mediates oxidative signalling by helping to downregulate ribosomal gene expression when cells are exposed to hydrogen peroxide. An active actin cytoskeleton is required for this function, because the cells blocked in actin polymerisation were unable to repress ribosomal gene transcription. Following the invertase secretion pattern, we hypothesize that oxidative stress induced by hydrogen peroxide could have affected the latter steps of secretion. This would explain why the Pkc1 function was required to repress ribosomal biogenesis.
journal_name
FEMS Yeast Resjournal_title
FEMS yeast researchauthors
Mitjana FV,Petkova MI,Pujol-Carrion N,de la Torre-Ruiz MAdoi
10.1111/j.1567-1364.2011.00754.xsubject
Has Abstractpub_date
2011-12-01 00:00:00pages
656-9issue
8eissn
1567-1356issn
1567-1364journal_volume
11pub_type
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