Does pharmacological castration as adjuvant therapy for prostate cancer after radiotherapy affect anxiety and depression levels, cognitive functions and quality of life?

Abstract:

INTRODUCTION:Adjuvant hormonotherapy for prostate cancer patients after radical radiotherapy has a well-established value. However, the impact of such treatment on the patients' quality of life remains to be elucidated. OBJECTIVE:The objective is to assess the impact of adjuvant hormonotherapy with luteinizing hormone-releasing hormone analogue after radical radiotherapy on anxiety and depression levels, cognitive function, sexual function and quality of life of prostate cancer patients. MATERIAL AND METHODS:Two groups of patients were tested: men treated with adjuvant hormonotherapy (88 patients) and men without hormonotherapy (61 patients). Anxiety, depression and cognitive functions were evaluated. Patients answered questions addressing problems linked to hormonal equilibrium. The patients rated their mental status, physical status, quality of life and quality of their relationship. RESULTS:There were no statistically significant differences between patients on hormonotherapy and without hormonotherapy in the level of anxiety and depression (p = 0.844 and p = 0.954) as well as in cognitive function (p = 0.661). Satisfactory sexual performance was preserved in 9/65 patients (14%) on hormonotherapy and the same was applied to 19/49 patients (39%) without hormonotherapy. The difference was statistically significant (p = 0.003). Hormonotherapy was associated with decreased libido (p = 0.031), hot flushes (p < 0.001) and sweating (p < 0.001). No statistically significant differences were found between the groups in the self-rated physical and psychological well-being (p = 0.476 and p = 0.597), quality of life (p = 0.622) and quality of relationship (p = 0.064). CONCLUSIONS:Adjuvant hormonotherapy enhances neither anxiety nor depression, does not impair cognitive function but has a negative effect on the patients' sexual function. It does not worsen self-rated quality of relationship and quality of life.

journal_name

Psychooncology

journal_title

Psycho-oncology

authors

Wiechno PJ,Sadowska M,Kalinowski T,Michalski W,Demkow T

doi

10.1002/pon.2095

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

346-51

issue

2

eissn

1057-9249

issn

1099-1611

journal_volume

22

pub_type

杂志文章
  • Cancer patients' trust in their physician-a review.

    abstract:OBJECTIVE:Patient's trust in their physician is crucial for desirable treatment outcomes such as satisfaction and adherence. In oncology, trust is possibly even more essential, due to the life-threatening nature of cancer. A review was undertaken of the current knowledge of the conceptualization, assessment, correlates...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,评审

    doi:10.1002/pon.1745

    authors: Hillen MA,de Haes HC,Smets EM

    更新日期:2011-03-01 00:00:00

  • Factor structure of the Beck Hopelessness Scale in individuals with advanced cancer.

    abstract:OBJECTIVE:Although the Beck Hopelessness Scale is often used with the seriously ill, its factor structure has been given relatively little consideration in this context. METHODS:The factor structure of this scale was examined in a sample of 406 ambulatory patients with advanced lung or gastrointestinal cancer, using a...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1540

    authors: Nissim R,Flora DB,Cribbie RA,Zimmermann C,Gagliese L,Rodin G

    更新日期:2010-03-01 00:00:00

  • Partners and close family members of long-term cancer survivors: health status, psychosocial well-being and unmet supportive care needs.

    abstract:BACKGROUND:A cancer diagnosis can have a profound impact on partners and close family members of patients. Little is currently known about the long-term impact. OBJECTIVES:The objective of this study is to describe health status, levels of anxiety and depression, unmet supportive care needs and positive outcomes in th...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.2050

    authors: Turner D,Adams E,Boulton M,Harrison S,Khan N,Rose P,Ward A,Watson EK

    更新日期:2013-01-01 00:00:00

  • Randomised controlled trial of a repeated consultation support intervention for patients with colorectal cancer.

    abstract:OBJECTIVE:UK healthcare policy for improving cancer outcomes supports participation of patients in care decisions with clinicians. Consultation Planning, Recording and Summarising (CPRS) has shown evidence of increasing patient decision self-efficacy, reducing uncertainty, and regret of decisions. This is the first tri...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/pon.4965

    authors: Shepherd SC,Hacking B,Wallace LM,Murdoch SE,Belkora J

    更新日期:2019-04-01 00:00:00

  • Changes in cancer worry associated with participation in ovarian cancer screening.

    abstract::While ovarian cancer is rare and screening is not recommended for most women, it is being studied as a way to reduce ovarian cancer mortality. As effective strategies for screening emerge it will be important to understand the quality of life (QOL) effects of participation in ovarian cancer screening. In this study, w...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/pon.1151

    authors: Andersen MR,Drescher CW,Zheng Y,Bowen DJ,Wilson S,Young A,McIntosh M,Mahony BS,Lowe KA,Urban N

    更新日期:2007-09-01 00:00:00

  • Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment.

    abstract:OBJECTIVE:Studies in breast cancer patients indicate that chemotherapy may cause subtle cognitive disturbances in some women, but the course is unclear. The current study evaluated the cognitive effects of adjuvant chemotherapy in post-menopausal breast cancer patients 1 year following completion of treatment. PATIENT...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1379

    authors: Collins B,Mackenzie J,Stewart A,Bielajew C,Verma S

    更新日期:2009-02-01 00:00:00

  • Evaluation of the Functional Assessment of Cancer Therapy-General Questionnaire (FACT-G) in a South American Spanish speaking population.

    abstract::There is an increasing interest by health care providers, not only in the effectiveness of cancer treatments, but also in patients' quality of life (QOL). The objective of the present study is to validate the Functional Assessment of Cancer Therapy-General (FACT-G) Version 2 as a measure of the QOL in a sample of 140 ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/1099-1611(200101/02)10:1<88::aid-pon483>3.

    authors: Dapueto JJ,Francolino C,Gotta I,Levin R,Alonso I,Barrios E,Afonzo Y,Cambiasso S

    更新日期:2001-01-01 00:00:00

  • Post-traumatic growth in breast cancer: how and when do distress and stress contribute?

    abstract:OBJECTIVE:While several theoretical models provide explanation for the genesis and development of post-traumatic growth (PTG) in the aftermath of stressful events, empirical evidence regarding the predictors and consequences of PTG in breast cancer patients in active treatment and early survivorship is inconclusive. Th...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4243

    authors: Groarke A,Curtis R,Groarke JM,Hogan MJ,Gibbons A,Kerin M

    更新日期:2017-07-01 00:00:00

  • Population-, intervention- and methodology-related characteristics of clinical trials impact exercise efficacy during adjuvant therapy for breast cancer: a meta-regression analysis.

    abstract:OBJECTIVE:Significant heterogeneity was highlighted in recent meta-analyses examining exercise effects in cancer patients, suggesting that some characteristics may moderate exercise efficacy. The objectives of this meta-analysis are (1) to investigate the influence of methodology, population and intervention studies' c...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,meta分析

    doi:10.1002/pon.3727

    authors: Carayol M,Delpierre C,Bernard P,Ninot G

    更新日期:2015-07-01 00:00:00

  • 'Being known': patients' perspectives of the dynamics of human connection in cancer care.

    abstract::In the context of a large study of effective and ineffective cancer care communications from the perspective of patients with cancer, the authors documented the pervasiveness of the desire for human connection. Analyzing accounts from 200 patients with diverse cancer experiences, they concluded that, while anonymity i...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.945

    authors: Thorne SE,Kuo M,Armstrong EA,McPherson G,Harris SR,Hislop TG

    更新日期:2005-10-01 00:00:00

  • The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer.

    abstract:BACKGROUND:The ability to identify men at genetically high-risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa-specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3814

    authors: Bancroft EK,Castro E,Bancroft GA,Ardern-Jones A,Moynihan C,Page E,Taylor N,Eeles RA,Rowley E,Cox K

    更新日期:2015-11-01 00:00:00

  • Knowledge, attitudes and beliefs of Arabic-Australians concerning cancer.

    abstract:OBJECTIVES:To explore with Arabic-Australian patients and their communities, the cultural context of cancer, both sporadic and inherited, by examining their beliefs about its causes and the modes of communication about cancer with family, friends and the community. METHOD:The design is an ethnographic and qualitative ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1884

    authors: Saleh M,Barlow-Stewart K,Meiser B,Tucker K,Eisenbruch M,Kirk J

    更新日期:2012-02-01 00:00:00

  • Why do older women delay presentation with breast cancer symptoms?

    abstract::Women who delay their presentation with breast cancer for three months or longer are more likely to be diagnosed with later stage disease and have poorer survival. Older women, who are at greater risk of developing breast cancer, are also more likely to delay their presentation. Factors associated with delayed present...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1030

    authors: Burgess CC,Potts HW,Hamed H,Bish AM,Hunter MS,Richards MA,Ramirez AJ

    更新日期:2006-11-01 00:00:00

  • Cancer-related cognitive impairment and associated factors in a sample of older male oral-digestive cancer survivors.

    abstract:OBJECTIVE:This study examines the demographic and clinical variables associated with cancer-related cognitive impairment (CRCI) in a sample of older, male, oral-digestive cancer survivors at VA Medical Centers in Boston and Houston. METHODS:A two-time point, longitudinal design was used, with cognitive assessment cond...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5131

    authors: Regier NG,Naik AD,Mulligan EA,Nasreddine ZS,Driver JA,Sada YH,Moye J

    更新日期:2019-07-01 00:00:00

  • Identifying psychological morbidity among people with cancer using the Hospital Anxiety and Depression Scale: time to revisit first principles?

    abstract:BACKGROUND:The aim of this review was to describe the findings and methodological quality of studies, which sought to validate the Hospital Anxiety and Depression Scale (HADS) against the Structured Clinical Interview for DSM in cancer populations. We also sought to compare the cut points recommended by these validatio...

    journal_title:Psycho-oncology

    pub_type: 杂志文章,评审

    doi:10.1002/pon.2057

    authors: Carey M,Noble N,Sanson-Fisher R,MacKenzie L

    更新日期:2012-03-01 00:00:00

  • Neurocognitive dysfunction in adult cerebellar medulloblastoma.

    abstract:OBJECTIVE:Impaired neurocognitive function (NCF) is a well-established consequence of pediatric medulloblastoma (MB) and its treatments. However, the frequency and features of neurocognitive dysfunction in adult-onset MB patients are largely unknown. METHODS:Adult patients (≥ 18 years) with MB who had received formal ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4920

    authors: Harrison RA,Kesler SR,Johnson JM,Penas-Prado M,Sullaway CM,Wefel JS

    更新日期:2019-01-01 00:00:00

  • Fear of disease progression and relevant correlates in acute leukemia patients prior to allogeneic hematopoietic stem cell transplantation.

    abstract:OBJECTIVE:Prior to hematopoietic stem cell transplantation (HSCT), and despite the high objective risks associated with HSCT, fear of progression (FoP) has only sparsely been studied in patients with acute leukemia until now. The aim of this study was the assessment of the prevalence of FoP, and any relevant correlates...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5397

    authors: Thiele S,Goebel S,Kröger N,Pedersen A

    更新日期:2020-08-01 00:00:00

  • Mediation of improvements in sun protective and skin self-examination behaviours: results from the healthy text study.

    abstract:OBJECTIVE:Melanoma is on the rise, especially in Caucasian populations exposed to high ultraviolet radiation such as in Australia. This paper examined the psychological components facilitating change in skin cancer prevention or early detection behaviours following a text message intervention. METHODS:The Queensland-b...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4007

    authors: Baker J,Finch L,Soyer HP,Marshall AL,Baade P,Youl P,Janda M

    更新日期:2016-01-01 00:00:00

  • Breast cancer meanings: a cognitive-developmental study.

    abstract:OBJECTIVE:This study addresses the meanings women with breast cancer attach to their illness within a cognitive-developmental framework. The aim of the present study was twofold: (i) to identify the content of women's meanings in five domains of breast cancer representation (identity, causes, consequences, timeline and...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3246

    authors: Travado L,Reis JC

    更新日期:2013-09-01 00:00:00

  • Exercise interventions and their effect on masculinity, body image, and personal identity in prostate cancer-A systematic qualitative review.

    abstract:OBJECTIVE:Men with prostate cancer face various body composition and psychosocial challenges following diagnosis. Movement-based interventions such as exercise may represent novel strategies to improve these important biopsychosocial changes. This systematic qualitative review aimed to examine the various exercise inte...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.5060

    authors: Langelier DM,D'Silva A,Shank J,Grant C,Bridel W,Culos-Reed SN

    更新日期:2019-06-01 00:00:00

  • The psychological impact of a cancer diagnosed during pregnancy: determinants of long-term distress.

    abstract:BACKGROUND:Cancer occurs during one in 1000-5000 of the approximately 6 million yearly US pregnancies identified by the American Pregnancy Association. Although a newly diagnosed cancer is associated with substantial distress, little is known about cancer's emotional impact on women when diagnosed during pregnancy, and...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1926

    authors: Henry M,Huang LN,Sproule BJ,Cardonick EH

    更新日期:2012-04-01 00:00:00

  • A follow-up study on men tested for BRCA1/BRCA2 mutations: impacts and coping processes.

    abstract:OBJECTIVE:The objective of this study was to examine cognitive, emotional, and behavioral impacts of testing for germline mutations in breast/ovarian cancer-associated genes (BRCA1/BRCA2) among men who undergo genetic testing. METHODS:A cross-sectional study compared 51 mutation carriers with 30 men who tested negativ...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.2106

    authors: Shiloh S,Dagan E,Friedman I,Blank N,Friedman E

    更新日期:2013-02-01 00:00:00

  • A qualitative study of women's experiences of familial ovarian cancer screening.

    abstract:OBJECTIVE:One risk management strategy that women at increased familial risk of ovarian cancer may use is screening. Until recently, this has been available as part of the UK Familial Ovarian Cancer Screening Study (UKFOCSS), using ultrasound scans of the ovaries and tumour marker blood tests. The present study aimed t...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3324

    authors: Lifford KJ,Clements A,Fraser L,Lancastle D,Brain K,PsyFOCS Management Group.

    更新日期:2013-11-01 00:00:00

  • Factors influencing distress in Indian cancer patients.

    abstract:BACKGROUND:The current study set out to identify distress in cancer patients undergoing curative treatment within India. PATIENTS AND METHODS:This study was carried out to measure distress and contributory factors in 103 cancer patients undergoing treatment with curative intent. The patients were interviewed using the...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.978

    authors: Pandey M,Thomas BC,Ramdas K,Nandamohan V

    更新日期:2006-06-01 00:00:00

  • The economic burden of cancer in the UK: a study of survivors treated with curative intent.

    abstract:OBJECTIVE:We aim to describe the economic burden of UK cancer survivorship for breast, colorectal and prostate cancer patients treated with curative intent, 1 year post-diagnosis. METHODS:Patient-level data were collected over a 3-month period 12-15 months post-diagnosis to estimate the monthly societal costs incurred...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3877

    authors: Marti J,Hall PS,Hamilton P,Hulme CT,Jones H,Velikova G,Ashley L,Wright P

    更新日期:2016-01-01 00:00:00

  • Longitudinal study of parent caregiving self-efficacy and parent stress reactions with pediatric cancer treatment procedures.

    abstract:BACKGROUND:Pain/distress during pediatric cancer treatments has substantial psychosocial consequences for children and families. We examined relationships between parents' caregiving self-efficacy, parents' affect in response to their children's cancer-related treatment procedures, and parents' symptoms of post-traumat...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3199

    authors: Harper FW,Peterson AM,Uphold H,Albrecht TL,Taub JW,Orom H,Phipps S,Penner LA

    更新日期:2013-07-01 00:00:00

  • Quality of life and psychological distress are differentially associated with distinct symptom-functional states in terminally ill cancer patients' last year of life.

    abstract:OBJECTIVE:Quality of life (QOL) and psychological distress at end of life (EOL) heavily depend on symptom distress and functional impairment, which may not deteriorate synchronously at EOL. METHODS:Using multivariate hierarchical linear modeling, we simultaneously evaluated the differential association of 5 previously...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.4775

    authors: Wen FH,Chen JS,Chou WC,Hsieh CH,Chang WC,Shen WC,Tang ST

    更新日期:2018-09-01 00:00:00

  • Sisters in hereditary breast and ovarian cancer families: communal coping, social integration, and psychological well-being.

    abstract:OBJECTIVE:We investigated the association between psychological distress and indices of social integration and communal coping among sisters from hereditary breast and ovarian cancer (HBOC) families. SAMPLE AND METHODS:Sixty-five sisters from 31 HBOC families completed the Brief Symptom Inventory-18 and the Colored Ec...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.1373

    authors: Koehly LM,Peters JA,Kuhn N,Hoskins L,Letocha A,Kenen R,Loud J,Greene MH

    更新日期:2008-08-01 00:00:00

  • Low-income women with early-stage breast cancer: physician and patient decision-making styles.

    abstract:BACKGROUND:Poor women have low rates of breast conservation therapy not explained by differences in insurance status or treatment preferences. The purpose of this study was to explore how low-income women make decisions about breast cancer treatment. METHODS:Twenty-five women diagnosed with early-stage breast cancer t...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.503

    authors: McVea KL,Minier WC,Johnson Palensky JE

    更新日期:2001-03-01 00:00:00

  • Managing fatigue after cancer treatment: development of RESTORE, a web-based resource to support self-management.

    abstract:OBJECTIVE:The aim of this study is to co-create an evidence-based and theoretically informed web-based intervention (RESTORE) designed to enhance self-efficacy to live with cancer-related fatigue (CRF) following primary cancer treatment. METHODS:A nine-step process informed the development of the intervention: (1) rev...

    journal_title:Psycho-oncology

    pub_type: 杂志文章

    doi:10.1002/pon.3747

    authors: Foster C,Calman L,Grimmett C,Breckons M,Cotterell P,Yardley L,Joseph J,Hughes S,Jones R,Leonidou C,Armes J,Batehup L,Corner J,Fenlon D,Lennan E,Morris C,Neylon A,Ream E,Turner L,Richardson A

    更新日期:2015-08-01 00:00:00