Abstract：
OBJECTIVE:To determine the survival of children =18 y, treated with immunosuppressive therapy (IST) using equine antithymocyte globulin (e-ATG) and cyclosporine (CsA). DESIGN:Prospective data entry as per a specified format. SETTING:Tertiary care hospital. PATIENTS:From January 1998 to December 2009, 40 children were diagnosed with acquired aplastic anemia; 33 patients, who received IST, were analyzed. 31 children (94%) received one course of e-ATG and CsA. 2 patients (6%) received two courses of ATG. INTERVENTION:Immunosuppressive therapy using equine ATG and cyclosporine. MAIN OUTCOME MEASURES:Overall response and overall survival. RESULTS:The overall response (complete response + partial response) to IST at 6 months was 87.9%. 8 (24.2%) patients achieved CR, 21 (63.6%) patients had PR and 4 (12.1%) patients did not respond to IST. Median follow-up was 24 (6-102) months. Overall survival at 24 months was 90%, with an actual survival of 85.4% at 5 years. Seventeen patients (51.5%) received G-CSF for a median duration of 32 (23-64) days. The patients who received G-CSF had fewer infectious complications (P=0.002), but G-CSF administration did not influence survival/ outcome. No patient developed myelodysplastic syndrome or acute leukemia. CONCLUSIONS:The survival of patients who respond to IST is excellent. Also, G-CSF reduces the infectious complications without conferring any survival advantage.
journal_name
Indian Pediatrjournal_title
Indian pediatricsauthors
Nair V,Sondhi V,Sharma A,Das S,Sharma Sdoi
10.1007/s13312-012-0086-5subject
Has Abstractpub_date
2012-05-01 00:00:00pages
371-6issue
5eissn
0019-6061issn
0974-7559pii
S097475591100298-Ijournal_volume
49pub_type
杂志文章abstract：:Six hundred and forty six cases in the age group 8-14 years suffering from paralytic poliomyelitis were analysed to find out the immunization status and its correlation with the incidence of poliomyelitis. In 382 cases where the immunization status was known, it was found that 325 (85.02%) cases were not immunized, 23...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:To assess the epidemiological and clinical characteristics of pediatric inpatients with COVID-19, early in the pandemic. METHODS:Clinical and laboratory profile and outcomes were studied for children (aged 1 month - 18 years) presenting between 1 April, 2020 and 20 May, 2020 with positive nasopharyngeal swab...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-10-15 00:00:00
abstract：OBJECTIVE:To evaluate the effectiveness of a community oral health awareness program given to mothers through trained community level workers (Junior Public Health Nurses (JPHNs) and Anganwadi workers (AWWs). METHODS:Oral health education materials were prepared based on the findings of a knowledge survey among commun...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:A holistic approach in assessment and plan for intervention in childhood malnutrition is the need of the hour. This is in the context of nutrition education program (NEP), undertaken under the National IAP action plan, 2015. In the crusade against malnutrition, an ABCDEFQ assessment scale is recommended, with aspects ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0820-5
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:To determine the clinical profile of children with Henoch-Schonlein purpura (HSP). DESIGN:Hospital based descriptive follow-up study. SUBJECTS:45 patients attending the Pediatric Rheumatology and Immunology clinic over the last 4 years. RESULTS:The patients were aged between 2.5-12 years with a male to fem...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:We examined associations of different adiposity measures with cortisol responses during the Trier Social Stress Test for children (TSST-C). DESIGN:Descriptive study. SETTING:Holdsworth Memorial Hospital, Mysore, India. PARTICIPANTS:Adolescents aged 13.5y from a birth cohort were recruited (N=269, 133 boys)...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-02-15 00:00:00
abstract：:Association of rotavirus gastroenteritis with histo-blood group antigens in children younger than 5 years admitted with diarrhea (n=389) was studied. Distribution of blood groups in rotavirus positive (n=96) and rotavirus negative (n=51) diarrhea gastroenteritis cases did not show any susceptibility to any blood group...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2016-07-08 00:00:00
abstract：OBJECTIVE:To examine the catch up growth in severely wasted children using energy dense local foods at a hospital based nutrition rehabilitation unit. DESIGN:Retrospective cohort. SETTING:In-patient ward at a tertiary care government pediatric hospital in Hyderabad. PATIENTS:Children with severe malnutrition (n=309)...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-010-0101-7
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of the ketogenic diet in Indian children with uncontrolled epilepsy. STUDY DESIGN:Prospective observational study. SETTING:Hospital based. PATIENTS:105 children (age 4 months to 18 years) with uncontrolled epilepsy enrolled in the ketogenic diet program over a period of 9 years and...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2009-08-01 00:00:00
abstract：:A 2-yr-old child with early onset diabetes and hypothyroidism, and diagnosed as Wolcott-Rallison Syndrome, developed two episodes of acute liver failure and recovered, but he remains at high risk of developing another episode of acute liver failure. Autoimmune, metabolic or genetic disorders should be evaluated in chi...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-12-15 00:00:00
abstract：:Cord problems at birth were prospectively studied in 12,000 singleton deliveries, of which 258 (2.15%) babies had cord abnormalities. Nearly 32% of these cases had fetal distress and 20.5% had 1 minute Apgar score less than 6. Of the various cord problems nuchal cord was noted in 79.1%, cord prolapse in 12.4% and true...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：OBJECTIVE:To document bone mineral density of children and adolescents with cystic fibrosis. DESIGN:Cross-sectional study. SETTING:Tertiary-care center of Northern India, July 2012 to August 2015. PARTICIPANTS:52 children aged 6-18 years with cystic fibrosis and 62 healthy controls of similar age and sex. METHODS:B...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-017-1065-7
更新日期：2017-07-15 00:00:00
abstract：:A randomized double blind placebo controlled trial was carried out to study the effect of phenobarbitone (PB) in preventing recurrences of simple and atypical febrile convulsions among children in the age group 6 months to 6 years. Children with simple febrile convulsions were randomly allocated to receive either phen...
journal_title：Indian pediatrics
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:To describe the utility of flexible fiberoptic bronchoscopy for the diagnosis and management in the neonatal ICU. METHODS:A retrospective, medical chart review was conducted in neonates who underwent flexible fiberoptic bronchoscopy over a period of 7 years. Besides demographic data and diagnostic findings, ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2019-07-15 00:00:00
abstract：OBJECTIVE:To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis. METHODS:Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocyt...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-014-0470-4
更新日期：2014-08-01 00:00:00
abstract：:Thirty-two infants above one month of age admitted to a tertiary care hospital with signs of infection and presumptive diagnosis of sepsis were included. Cytokine levels of tumor necrosis factor alpha (TNFmu) and interleukin-6 (IL 6) were estimated at admission and after 48 to 72 hr, and their relationship examined to...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:India has been emphasizing the interrelationship between primary health care, maternal and child health, and family planning as the major problem for family welfare. Family welfare has been adopted at the national level by the government. Integration of these 2 components of family welfare maternal and child health ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1983-06-01 00:00:00
abstract：:We present the case of a 3-month-old girl who was admitted with complaints of loose stools and respiratory distress. She also had a history of rash and alopecia. Laboratory investigations revealed lymphopenia with reduced immunoglobulin G and immunoglobulin A. Lymphocyte subset analysis by flow cytometry revealed T-B+...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-08-15 00:00:00
abstract：OBJECTIVE:To identify the factors influencing brain injury in infants with congenital heart disease (CHD) after cardiac surgery. METHODS:This retrospective study investigated 103 infants with CHD undergoing cardiac surgery between January 2013 and February 2016. Pre- and postoperative amplitude-integrated electroencep...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2020-02-15 00:00:00
abstract：JUSTIFICATION:Seizures constitute the most common neurological problem in children and the majority of epilepsy has its onset in childhood. Appropriate diagnosis and management of childhood epilepsy is essential to improve quality of life in these children. Evidence-based clinical practice guidelines, modified to the I...
journal_title：Indian pediatrics
pub_type： 杂志文章,实务指引
doi：
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To estimate the prevalence of Iodine Deficiency Disorders, and household consumption of adequately iodized salt in Damoh district, Madhya Pradesh in 2016. METHODS:Cross-sectional study with cluster sampling method was used among school-going children. 30 clusters, each with 90 children were selected to acces...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2018-07-15 00:00:00
abstract：:In an earlier study usefulness and validity of calf circumference in the identification of low birth weight (LBW) infants was reported. To evolve a simple indicator in identifying LBW in community, comparative evaluation of three simple measurements, i.e., circumferences of calf (CC), thigh (TC) and arm (AC) was done ...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:To compare the rate of optimal position of UVC between modified Shukla's formula and JSS formula. METHODS:Babies requiring umbilical vein catheterization were randomized to either Shukla or JSS formula group. Post-procedure X-ray was taken to check the tip position. Tip of the UVC just above the diaphragm (T...
journal_title：Indian pediatrics
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2019-03-15 00:00:00
abstract：:Twenty-six neonates were diagnosed to have acinetobacter sepsis during 1986-90, representing 6.5% of all cases of bacteriologically proven sepsis. Of these 19 neonates were low birth weight (LBW) 12 were small for gestational age (SGA). Nineteen neonates had early-onset sepsis. The male to female ratio was 9:17. The h...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The prevalence of Attention deficit hyperactivity disorder was estimated in 500 adolescents using Conners' parents and teachers rating scales. Thirty six (7.2%) adolescents had positive scores on both the scales. The parents and teachers also completed a Diagnostic and Statistical Manual-IV based questionnaire which s...
journal_title：Indian pediatrics
pub_type： 信件
doi：10.1007/s13312-014-0350-y
更新日期：2014-02-01 00:00:00
abstract：:The objectives of this study were to evaluate whether a newborn or a neonate is capable of responding immunologically after BCG vaccination and to find out if this immunity persists for one year. Normal infants aged between 0 days-3 months brought to immunization centre were included in the study. In vitro leukocyte m...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Fifty newborns, 25 full term SFDs (small for date) and 25 full term AGAs (appropriate for gestational age) were taken up for comparative study of their behavior using BNBAS (Brazelton's neonatal behavior assessment scale). The study revealed that full term SFDs performed significantly poorly on all items under cluster...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Lysinuric protein intolerance is an inherited disorder of transport of cationic amino acids, causing amino aciduria. CASE CHARACTERISTICS:A 3-year-old boy with 12 month history of episodic change in behavior (decreased sleep, poor interaction), stunted growth and hyperammonemia. OUTCOME:Genetic analysis re...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：10.1007/s13312-016-0920-2
更新日期：2016-08-08 00:00:00
abstract：OBJECTIVE:To assess the safety and reactogenecity of indigenously produced measles vaccine derived from EZ strain. DESIGN:A longitudinal clinical follow up after vaccination. SETTING:Hospital based and home follow up, as required. SUBJECTS:12,470 children, 9 to 15 months old, immunized with measles vaccine of EZ str...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:We report an adolescent with recurrent bilateral parotitis with pneumoparotitis and subcutaneous emphysema due to self pneumoinsufflation by a Valsalva like maneuver. Investigations for recurrent parotitis did not yield any clue. His la belle indifference, prolonged school absence and the presence of sibling rivalry h...
journal_title：Indian pediatrics
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
