Abstract:
PURPOSE:The purpose of this study was to investigate the reliability and the clinical applicability of the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) as a method of determining in vitro chemosensitivity in patients with gastric cancer. MATERIALS AND METHODS:A total of 243 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2010. We evaluated the effectiveness of the ATP-CRA assay in determining the chemosensitivity of gastric cancer specimens using eleven chemotherapeutic agents - etoposide, doxorubicin, epirubicin, mytomicin, 5-fluorouracil, oxaliplatin, irinotecan, docetaxel, paclitaxel, methotraxate, and cisplatin - for chemosensitivity studies using ATP-CRA. We assessed the failure rate, the cell death rate, and the chemosensitivity index. RESULTS:The failure rate of ATP-CRA was 1.6% (4/243). The mean coefficient of variation for triplicate ATP measurements was 6.5%. Etoposide showed the highest cell death rate (35.9%) while methotrexate showed the lowest (16.6%). The most active chemotherapeutic agent was etoposide, which most frequently ranked highest in the chemosensitivity test: 31.9% (51/160). Oxaliplatin was more active against early gastric cancers than advanced gastric cancers, whereas docetaxel was more active against advanced cancers. The lymph node negative group showed a significantly higher cell death rate than the lymph node positive group when treated with doxorubicin, epirubicin, and mitomycin. CONCLUSIONS:ATP-CRA is a stable and clinically applicable in vitro chemosensitivity test with a low failure rate. The clinical usefulness of ATP-CRA should be evaluated by prospective studies comparing the regimen guided by ATP-CRA with an empirical regimen.
journal_name
J Gastric Cancerjournal_title
Journal of gastric cancerauthors
Park S,Woo Y,Kim H,Lee YC,Choi S,Hyung WJ,Noh SHdoi
10.5230/jgc.2010.10.4.155subject
Has Abstractpub_date
2010-12-01 00:00:00pages
155-61issue
4eissn
2093-582Xissn
2093-5641journal_volume
10pub_type
杂志文章abstract:PURPOSE:Recently, laparoscopy-assisted gastrectomy (LAG) has been widely accepted modality for early gastric cancer in Korea. The indication of LAG may be extended in an experienced institution. In our institution, the first case of laparoscopy-assisted gastrectomy (LAG) for gastric cancer was performed in May 1998. We...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2012.12.1.18
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:It is hypothesized that robotic gastrectomy may surpass laparoscopic gastrectomy after the operators acquire long-term experience and skills in the manipulation of robotic arms. This study aimed to evaluate the long-term learning curve of robotic distal gastrectomy (RDG) for gastric cancer compared with laparos...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2016.16.4.240
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:In resectable gastric cancer, choice regarding the extent of resection depends on tumor size, location, and distance from resection margin. However, there remains controversy for choice of resection for tumors in the middle third of the stomach. This study investigated patients who underwent gastrectomy in orde...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2010.10.4.226
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Gastric cancer has a high incidence and mortality rate in Korea. Despite a growing older population and an increase in the number of older patients with gastric cancer, the older patients are not willing to undergo surgery due to their operative risks. Hence, to determine the clinical characteristics and outcom...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2011.11.4.200
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:Reoperations after gastrectomy for gastric cancer are performed for many types of complications. Unexpected reoperations may cause mental, physical, and financial problems for patients. The aim of the present study was to evaluate the causes of reoperations and to develop a strategic decision-making process for...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2013.13.4.242
更新日期:2013-12-01 00:00:00
abstract::As the incidence of early gastric cancer increases, laparoscopic surgery has become one of the treatments of choice for gastric cancer. With the increase of laparoscopic surgery, the chance of discovering aberrant anatomy during the operation also increases. We present a case of laparoscopic total gastrectomy in gastr...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2013.13.3.188
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:To determine the diagnostic utility of a frozen section biopsy in patients undergoing endoscopic submucosal dissection (ESD) for early gastric neoplasms with obscure margins even with chromoendoscopy using acetic acid and indigo carmine (AI chromoendoscopy). MATERIALS AND METHODS:The lateral spread of early ga...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2011.11.3.155
更新日期:2011-09-01 00:00:00
abstract::We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the s...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2014.14.1.63
更新日期:2014-03-01 00:00:00
abstract:PURPOSE:Bone metastasis from stomach cancer occurs only rarely and it is known to have a very poor prognosis. This study examined the clinical characteristics and prognosis of patients who were diagnosed with stomach cancer and bone metastasis. MATERIALS AND METHODS:The subjects were 19 patients who were diagnosed wit...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2011.11.1.38
更新日期:2011-03-01 00:00:00
abstract::Surgery is still considered to be the mainstay for the treatment of localized gastric cancer with negative margins (R0-resection) and an adequate lymph-node-dissection (D2-lymphadenectomy). Unfortunately, most cases of gastric cancer are only diagnosed at an advanced stage due to frequent recurrences after primary res...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2013.13.2.73
更新日期:2013-06-01 00:00:00
abstract::Few surgeons have adopted pancreaticoduodenectomy (PD) for the treatment of advanced gastric cancer (AGC) invading the pancreas or duodenum because it remains controversial whether its prognostic benefits outweigh the high morbidity rates in such advanced cases. However, recent technical advances have revived diverse ...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2019.19.e24
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Before expanding our indications for laparoscopic gastrectomy to advanced gastric cancer and adopting reduced port laparoscopic gastrectomy, we analyzed and audited the outcomes of laparoscopy-assisted distal gastrectomy (LADG) for adenocarcinoma; this was done during the adoptive period at our institution thro...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2015.15.1.29
更新日期:2015-03-01 00:00:00
abstract:Purpose:We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor or prognostic factor for overall survival in gastric cancer...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2017.17.e33
更新日期:2017-12-01 00:00:00
abstract::Gastric volvulus is an uncommon clinical entity. There are three types of gastric volvulus; organoaxial, mesenteroaxial and combined type. This condition can lead to a closed-loop obstruction or strangulation. Traditional surgical therapy for gastric volvulus is based on an open approach. Here we report a successful c...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2015.15.2.147
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2017.17.e21
更新日期:2017-09-01 00:00:00
abstract::Alpha-fetoprotein-Producing gastric cancer is associated with poor prognosis because of frequent liver and lymph node metastasis. We present a case with synchronous liver metastasis who survived for 5 years. A 69-year-old man with upper abdominal pain was referred to our hospital. Gastrointestinal endoscopy revealed a...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2013.13.1.58
更新日期:2013-03-01 00:00:00
abstract:Purpose:Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GC-ERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERA...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2018.18.e24
更新日期:2018-09-01 00:00:00
abstract:Purpose:Postoperative adjuvant chemotherapy is usually prescribed to improve the survival of patients with advanced gastric cancer who undergo curative surgery. This study was designed to determine the impact that the degree of compliance with chemotherapy has on the prognosis of patients with gastric cancer. Material...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2018.18.e4
更新日期:2018-03-01 00:00:00
abstract:Purpose:The guidelines for pathological evaluation of early gastric cancer (EGC) recommend wider section intervals for surgical specimens (5-7 mm) than those for endoscopically resected specimens (2-3 mm). Studies in surgically resected EGC specimens showed not negligible lymph node metastasis risks in EGCs meeting the...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2020.20.e14
更新日期:2020-06-01 00:00:00
abstract:Purpose:For unresectable or initially metastatic gastric cancer, conversion surgery (CVS), after systemic chemotherapy, has received attention as a treatment strategy. This study evaluated the prognostic value of ypTNM stage and the oncologic outcomes in patients receiving CVS. Materials and Methods:A retrospective re...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2020.20.e20
更新日期:2020-09-01 00:00:00
abstract:Purpose:Patients with gastric cancer who receive neoadjuvant therapy are staged before treatment (cStage) and after treatment (ypStage). We aimed to compare the prognostic reliability of cStage and ypStage, alone and in combination. Materials and Methods:Data for all patients who received neoadjuvant therapy followed ...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2020.20.e41
更新日期:2020-12-01 00:00:00
abstract::Splenic hilar lymph node dissection has been the standard treatment for advanced proximal gastric cancer. Splenectomy is typically performed as part of this procedure. However, splenectomy has some disadvantages, such as increased risk of postoperative complications, especially pancreatic fistula. Moreover, patients w...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2020.20.e8
更新日期:2020-03-01 00:00:00
abstract:PURPOSE:Since there are no proven tumor markers that reflect the course of gastric cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are commonly used alternatives. However, the degree of progression that corresponds to an increase in these markers, and the values of these markers at differe...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2014.14.2.123
更新日期:2014-06-01 00:00:00
abstract::Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC), aiming to decrease the complication rate and improve postoperative quality of life. According to the Japanese gastric cancer treatment guidelines, PPG can be performed for cT1N0M0 gastric cancer locat...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2016.16.2.63
更新日期:2016-06-01 00:00:00
abstract::Surgeons occasionally encounter a patient with a gastric cancer invading an adjacent organ, such as the pancreas, liver, or transverse colon. Although there is no established guideline for treatment of invasive gastric cancer, combined resection with radical gastrectomy is conventionally performed for curative purpose...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2015.15.3.214
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:The Korean Gastric Cancer Association (KGCA) has conducted nationwide surveys every 5 years, targeting patients who received surgical treatment for gastric cancer. We report the results of the 2014 nationwide survey and compare them to those of the 1995, 1999, 2004, and 2009 surveys. MATERIALS AND METHODS:From...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2016.16.3.131
更新日期:2016-09-01 00:00:00
abstract:Purpose:Despite its clinical benefits, enhanced recovery after surgery (ERAS) is less widely implemented for gastric cancer surgery. This nationwide survey investigated the current status of the implementation of ERAS in perioperative care for gastric cancer surgery in South Korea. Materials and Methods:This survey en...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2019.19.e3
更新日期:2019-03-01 00:00:00
abstract::Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters are used to assess the inflammatory status during cancer treatment. It is important to s...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2019.19.e29
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Despite the compelling scientific and clinical data supporting the use of early oral nutrition after major gastrointestinal surgery, traditional bowel rest and intravenous nutrition for several postoperative days is still being used widely after gastric cancer surgery. MATERIALS AND METHODS:A phase II study wa...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2011.11.2.101
更新日期:2011-06-01 00:00:00
abstract::Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like car...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2016.16.1.1
更新日期:2016-03-01 00:00:00