Abstract:
OBJECTIVES:To determine the familial aggregation of narcolepsy from perspectives of clinical symptomatology, polysomnographic data, and human leukocyte antigen (HLA) typing. METHODS:This was a Family study at the University-affiliated hospital. The participants were narcolepsy probands and their first degree relatives, and, also, age and sex matched unrelated healthy controls. Interventions were not applicable. MEASUREMENTS AND RESULTS:All study subjects underwent structured interviews, overnight polysomnography followed by a multiple sleep latency test (MSLT), and HLA typing. Altogether, 33 probands and 81 first degree relatives (response rate 65%) were recruited. Among the relatives, 12.3% were diagnosed with narcolepsy and 39.5% had narcolepsy spectrum as defined by unexplained abnormal MSLT (shortened MSL and SOREMP) results. The relative risk of narcolepsy in first degree relatives was 361.8. Familial aggregation of narcolepsy symptoms, excessive daytime sleepiness, HLA status, abnormal MSLT, and nocturnal polysomnographic findings were observed. CONCLUSIONS:The familial risk of narcolepsy among first degree relatives is much higher than previously reported. There exists a spectrum of narcolepsy features among relatives, ranging from full clinical tetrads to asymptomatic abnormal MSLT findings.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Wing YK,Chen L,Lam SP,Li AM,Tang NL,Ng MH,Cheng SH,Ho CK,Mok V,Leung HW,Lau A,Chan MH,Chan HS,Chan PSdoi
10.1016/j.sleep.2011.05.007subject
Has Abstractpub_date
2011-12-01 00:00:00pages
947-51issue
10eissn
1389-9457issn
1878-5506pii
S1389-9457(11)00264-4journal_volume
12pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract:BACKGROUND:Sleep problems are highly prevalent in early childhood. In many cases, parents seek professional help when they suspect their child suffers from a sleep problem. The aim of this study was to explore sleep, demographic and cultural factors associated with parental definition of child sleep problem in a large-...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2010.10.008
更新日期:2011-05-01 00:00:00
abstract::We present a case of violent sleep-related behaviour in a patient with narcolepsy with cataplexy (NC) and REM sleep behaviour disorder (RBD), causing injuries to his wife that resulted in charge of assault, followed by a divorce case. This observation pinpoints that RBD in NC can arise early in a patient's life and th...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2010.07.001
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:Restless legs syndrome (RLS) seems to improve immediately after a single dose of dopamine-agonists (DA). The aim of the present study was to investigate the acute effects of a low standard dose of pramipexole in RLS drug-naïve patients. METHODS:A single-blind placebo-controlled study in 32 consecutive idiopa...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2006.10.008
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To determine the sleep architecture and sleep respiratory abnormalities and to correlate with sleep symptoms in patients with Myotonic dystrophy type 1 (DM1). METHODS:We recruited a cohort of genetically confirmed patients with DM1, who attended the Neuromuscular clinic between July 2016 and December 2019. C...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.12.036
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Adaptive servo-ventilation (ASV) is a well-established treatment of central sleep apnea (CSA) related to congestive heart failure (CHF). Few studies have evaluated the effectiveness and adherence in patients with CSA of other etiologies, and even less is known about treatment of CSA in patients of post ische...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2014.06.013
更新日期:2014-11-01 00:00:00
abstract:STUDY OBJECTIVES:Few commercially available brands of actigraphs (ACT) have been subjected to rigorous validation with infant participants. The purpose of this study was to examine the agreement between concurrent polysomnography (PSG) and one brand of ACT (AW-64, Mitter Co. Inc.) using appropriate statistical techniqu...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2009.08.010
更新日期:2010-02-01 00:00:00
abstract::We describe a polysomnographic observation of the acute phase of the alcohol withdrawal syndrome, characterized by an alteration of the sleep-wake cycle and by the absence of non-rapid eye movement sleep. An atypical transitional state between rapid eye movement sleep and wake with hallucinations and enacting-dream be...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(02)00014-x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:Altered brain iron homeostasis with regional iron deficiency has been previously reported in several studies of restless legs syndrome (RLS) patients. Inconsistencies still exist, however, in the reported iron changes in different brain regions and different RLS phenotypes. The purpose of this study was to a...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.05.001
更新日期:2016-06-01 00:00:00
abstract::Sleep is important for optimal cognitive functioning across the lifespan. Among older adults (≥55 years), self-reported short and long sleep durations have been repeatedly, albeit inconsistently, reported to elevate the risk for poor cognitive function. This meta-analytic review quantitatively summarizes the risk for ...
journal_title:Sleep medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.sleep.2015.08.021
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Very few prospective studies examine the relationship between childhood sleep problems and subsequent substance use. In this study, we examined how sleep problems at ages 3-8 predicted onset of alcohol, cigarette, and marijuana use in adolescence. We also investigated the relationships between childhood slee...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2008.06.015
更新日期:2009-08-01 00:00:00
abstract:INTRODUCTION:We investigated the impact of delayed sleep phase disorder (DSPD) on the daily lives of adolescents and their families. METHOD:In this qualitative study, six adolescents with DSPD, and six parents were given in-depth interviews. Using thematic analysis, we merged open codes into themes that reflected the ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.05.022
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Sleep-disordered breathing (SDB) is more prevalent in stroke patients than age- and sex-matched controls, but the relationship between SDB and functional outcome of stroke patients is unclear. The aim of our study was to determine the prevalence of SDB in ischemic stroke and its influence on func...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2008.08.006
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To provide normative values for sleep macroarchitecture of healthy children aged 1-18 years using the AASM sleep scoring criteria, assessing the effects of gender, age, and Tanner pubertal stage. METHODS:One-night polysomnography was performed at subjects' habitual bedtimes in 16 laboratories on 209 healthy ...
journal_title:Sleep medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.sleep.2010.11.011
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:The self-efficacy measure for sleep apnea (SEMSA) questionnaire was shown to be an effective tool to assess adherence-related cognitions on continuous positive airway pressure (CPAP) therapy in obstructive sleep apnea (OSA) subjects. SEMSA helps to solicit fundamental information for formulating strategies t...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2013.04.023
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:The doctor-patient relationship has an important role in the delivery of high-quality healthcare. The aim of the present study was to explore and evaluate the impact of sleep severity and fatigue manifestations on doctor-patient relationships. METHODS:The present study was an analysis of a cross-sectional s...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.02.015
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To compare individuals with traumatic brain injury (TBI) to healthy controls (CTLs) on measures of sleepiness, fatigue, and sleep, and explore correlates of sleepiness and fatigue separately for each group. METHODS:Participants were 22 adults with moderate/severe TBI (time since injury ≥ 1 year; mean=53.0 ±...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2012.02.010
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:To date few studies have examined how multiple layers of influences shape the emergence of bed-sharing practices in the first 2 years postpartum. In our report, we examined bed-sharing in a large multiethnic sample, exploring the influences of three broad classes of influence on bed-sharing at single time po...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2013.04.019
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:Restless legs syndrome (RLS) is a common neurological disorder but it is not sufficiently recognized in children and adolescents. It often overlaps with growing pains in children, and as a result the clinical characteristics of pediatric RLS are not well studied, especially in Asia. The purpose of this study...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.12.016
更新日期:2020-05-01 00:00:00
abstract:STUDY OBJECTIVES:Many healthcare workers live with sleep disorders and may be unaware of their condition. We aimed to ascertain sleep disorder symptoms including high-risk obstructive sleep apnea (hrOSA), significant insomnia, and excessive daytime sleepiness (EDS) by work shift in a sample of healthcare workers. We ai...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.07.028
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:The association between restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) has seldom been reported. There is one study reporting improvement of RLS symptoms severity in patients naive of treatment after initiation of continuous positive airway pressure (CPAP) for OSAS. The aim of this s...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.06.023
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Morning headaches are often ascribed to patients with sleep apnea syndrome (SAS) but the etiology of headaches in SAS is unclear. Given the relationship between oxygen and other headache syndromes, nocturnal hypoxia might be one factor contributing to headaches in SAS. METHODS:All subjects 18-80 years of ag...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(02)00006-0
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:Actigraphy is a non-intrusive method of recording rest/activity cycles as well as a surrogate for sleep/wake activity. Standard actigraphy analysis is limited in ascribing discrete movement events to wake status during sleep. We applied a novel algorithm to overnight actigraphy data recorded simultaneously wi...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.02.020
更新日期:2020-07-01 00:00:00
abstract::Objective: This study examines specific hypotheses that both sleep loss and behavioral changes occurring with the time shifts for Daylight Savings Time (DST) significantly effect the number of fatal traffic accidents in the United States of America.Background: It has been reported that there is a significant increase ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(00)00032-0
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Insomnia represents a significant public health burden worldwide. Antidepressants have often been the insomnia treatment of choice in recent decades. Some tricyclic antidepressants (TCAs) have been shown to improve sleep efficiency. OBJECTIVE:Assess the efficacy and safety of TCAs for the treatment of insom...
journal_title:Sleep medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.sleep.2017.03.007
更新日期:2017-06-01 00:00:00
abstract::The preference of the sleep/wake cycle can be grouped into categories or chronotypes. Inflammatory bowel disease (IBD) has been linked to poor sleep quality which correlates with disease severity. Social jet lag (SJL) is the difference between sleep timing on work and free days and is a marker for circadian misalignme...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.08.002
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Prior studies report less favorable sleep characteristics among non-Whites as compared with non-Hispanic Whites. However, few population-based studies have used objective measures of sleep duration, especially in more than two racial/ethnic groups. We tested whether objectively estimated sleep duration and s...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2015.07.005
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Restless legs syndrome (RLS) often responds to agents that enhance dopamine neurotransmission. The present 12-week study aimed to evaluate the efficacy and adverse events of pramipexole (PPX) for the treatment of adult, Chinese people with primary RLS. METHODS:A total of 204 Chinese people with RLS were ran...
journal_title:Sleep medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.sleep.2014.09.015
更新日期:2015-01-01 00:00:00
abstract:STUDY OBJECTIVE:We analyzed archival data from an epidemiology study to test the association between vitamin use and sleep. DESIGN:Random digit dialing was used to recruit 772 people ranging in age from 20 to 98 for a study of people's sleep experience. These individuals completed a set of questionnaires about their s...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2006.12.009
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:Poor sleep may be a risk factor for obesity. Previous studies have mainly investigated the effects of sleep duration on body mass index, but research considering overall sleep quality and other anthropometric measures is scarce. The aim of this study was to examine the association between sleep quality and di...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2015.05.023
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:There have been few quality of life (QoL) studies of patients with restless legs syndrome (RLS) in Asian countries. We studied the QoL of patients with RLS and compared it to normal controls and patients with hypertension, type 2 diabetes, or osteoarthritis in Korea. METHODS:A total of 215 RLS patients (141...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2012.05.005
更新日期:2012-10-01 00:00:00