Abstract:
BACKGROUND:Cystic fibrosis (CF) is caused by a misfunctional CF transmembrane conductance regulator (CFTR) protein, which is believed to contributes to the regulation of the airway surface liquid (ASL) pH. This study investigated acid and base secretion in freshly excised human nasal tissues from CF patients homozygous for the ΔF508 mutation. METHODS:Human nasal mucosa was collected during sinus surgery and investigated in Ussing chambers. Mucosal equilibrium pH values and rate of acid and base secretion were determined using the pH-stat technique. RESULTS:The equilibrium pH of nasal epithelia from ΔF508 CF patients with chronic rhinosinusitis (CRS) was pH = 7.08 ± 0.09 and was significantly lower compared to nasal epithelia from CRS patients without CF (pH = 7.33 ± 0.06) and normal subjects (pH = 7.34 ± 0.08, n = 6). The rate of base secretion in CF nasal tissues was 11.8 ± 2.4 nmol · min(−1) · cm(−2), which was significantly lower than normal (57.2 ± 9.2 nmol · min(−1) · cm(−2)). The HCO3(−) secretory rate was further increased by forskolin by 16.1% in normal, but not in CF tissues. CONCLUSION:Our data suggests that CF patients exhibited significantly lower base secretion by the nasal airway epithelium. It is possible that improper regulation of ASL pH in CF may negatively impact the innate host defense system.
journal_name
Int Forum Allergy Rhinoljournal_title
International forum of allergy & rhinologyauthors
Cho DY,Hwang PH,Illek B,Fischer Hdoi
10.1002/alr.20028subject
Has Abstractpub_date
2011-03-01 00:00:00pages
123-7issue
2eissn
2042-6976issn
2042-6984journal_volume
1pub_type
杂志文章abstract:BACKGROUND:Multiple prospective and retrospective studies have reported results from balloon-only procedures and hybrid balloon sinus surgeries through intermediate follow-up periods of up to 1 year. Long-term durability results beyond 2 years are limited. METHODS:One-year results from the original study of standalone...
journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21024
更新日期:2012-05-01 00:00:00
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journal_title:International forum of allergy & rhinology
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pub_type: 共识发展会议,杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
doi:10.1002/alr.21309
更新日期:2014-05-01 00:00:00
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-01-01 00:00:00
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journal_title:International forum of allergy & rhinology
pub_type: 杂志文章
doi:10.1002/alr.21600
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00