Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases.

Abstract:

PURPOSE:Despite advances in therapy for the treatment of metastatic colorectal cancer, many patients die of hepatic disease. Current immunotherapeutic strategies are likely limited by inhibitory signals from the tumor. To successfully eliminate tumor deposits within an organ, an appropriate immunologic milieu to amplify antitumor responses must be developed. METHODS:We used a murine model utilizing the CT26 colon cancer cell line to analyze primary and memory tumor-specific T-cell responses induced by an attenuated actin A and internalin B deleted immunodominant tumor-associated antigen expressing strain of Listeria monocytogenes for the treatment of metastatic colorectal cancer. RESULTS:Treatment of mice bearing established hepatic metastases with this L. monocytogenes strain led to the generation of a strong initial tumor-specific cytotoxic CD8(+) T-cell response that successfully treated 90% of animals. Tumor antigen-specific central and effector memory T cells were also generated and protected against tumor rechallenge. These cell populations, when measured before and after tumor rechallenge, showed a marked expansion of antigen-specific effector CD8(+) effector memory T cells. This strain of L. monocytogenes was able to down-modulate the expression of the immune checkpoint molecule, PD-1, within the tumor microenvironment but had variable effects on CTLA-4 expression. CONCLUSIONS:This L. monocytogenes strain generated a highly effective antitumor T-cell response, providing a basis for the development of this vaccine platform in patients with liver metastases.

journal_name

Ann Surg Oncol

authors

Olino K,Wada S,Edil BH,Pan X,Meckel K,Weber W,Slansky J,Tamada K,Lauer P,Brockstedt D,Pardoll D,Schulick R,Yoshimura K

doi

10.1245/s10434-011-2037-0

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

S597-607

eissn

1068-9265

issn

1534-4681

journal_volume

19 Suppl 3

pub_type

杂志文章
  • Factors associated with variance in compliance with a sentinel lymph node dissection quality measure in early-stage breast cancer.

    abstract:BACKGROUND:Guidelines recommend sentinel lymph node dissection (SLND) for patients with clinical stage I/IIA/IIB breast cancer; however, a significant fraction of patients do not undergo this procedure. We sought to identify factors associated with noncompliance with the SLND benchmark in early-stage breast cancer. MA...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1248-0

    authors: Olaya W,Wong J,Morgan JW,Truong C,Roy-Chowdhury S,Kazanjian K,Lum S

    更新日期:2010-10-01 00:00:00

  • Risk of colorectal cancer in chronic kidney disease: a matched cohort study based on administrative data.

    abstract:BACKGROUND:The risk of colorectal cancer (CRC) in chronic kidney disease (CKD) patients relative to the general population is unknown. The aim of this population-based study was to investigate the risk of CRC in patients with CKD. METHODS:The study cohort included patients aged ≥18 years diagnosed with CKD between 200...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-013-3065-8

    authors: Wu MY,Chang TC,Chao TY,Huang MT,Lin HW

    更新日期:2013-11-01 00:00:00

  • Treatment of Diaphragmatic Hernia Occurring After Transhiatal Esophagectomy.

    abstract:BACKGROUND:Postesophagectomy diaphragmatic hernia (DH) is an uncommon problem but an important one to recognize and treat because of the risk of significant complications such as incarceration and strangulation. Diaphragmatic hernia appears to occur more frequently following transhiatal esophagectomy (THE) than after t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4366-x

    authors: Narayanan S,Sanders RL,Herlitz G,Langenfeld J,August DA

    更新日期:2015-10-01 00:00:00

  • Standard Clinical Protocol for Bidirectional Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Systemic Leucovorin, 5-Fluorouracil, and Heated Intraperitoneal Oxaliplatin in a Chloride-Containing Carrier Solution.

    abstract:BACKGROUND:Intraperitoneal chemotherapy has an established role in the treatment of selected patients with colorectal peritoneal metastases. Oxaliplatin is highly suitable as a chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC), but its use to date has been limited because of the morbidity cau...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5665-6

    authors: Mehta AM,Huitema AD,Burger JW,Brandt-Kerkhof AR,van den Heuvel SF,Verwaal VJ

    更新日期:2017-04-01 00:00:00

  • Incidence, Risk Factors, and Prevention Strategies for Venous Thromboembolism after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

    abstract:BACKGROUND:The risk factors and incidence of venous thromboembolism (VTE) are not well defined in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We sought to characterize the incidence, risk factors, and pharmacothromboprophylaxis strategies for VTE after CRS/HIPEC....

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-019-07414-8

    authors: Khan S,Kelly KJ,Veerapong J,Lowy AM,Baumgartner JM

    更新日期:2019-07-01 00:00:00

  • Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer.

    abstract:BACKGROUND:Isolated hepatic perfusion has been used in patients with colorectal cancer (CRC) metastatic to the liver. We sought to determine whether perfusion with antisense oligodeoxynucleotides results in the downregulation of beta-catenin and whether this improves tumor response to isolated limb perfusion (ILP) in a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.10.005

    authors: Canter RJ,Kesmodel SB,Heitjan DF,Veeramachaneni NK,Mokadam NA,Drebin JA,Fraker DL

    更新日期:2005-09-01 00:00:00

  • Outcomes of Lymph Node Dissection for Non-metastatic Pancreatic Neuroendocrine Tumors: A Propensity Score-Weighted Analysis of the National Cancer Database.

    abstract:BACKGROUND:Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use of LND and overall survival (OS). METHODS:Patients with resecte...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07506-5

    authors: Mao R,Zhao H,Li K,Luo S,Turner M,Cai JQ,Blazer D 3rd

    更新日期:2019-09-01 00:00:00

  • Optimal submucosal invasion of early gastric cancer for endoscopic resection.

    abstract:BACKGROUND:A small differentiated gastric cancer with minute submucosal invasion after endoscopic resection is regarded as the curative resection criterion of an expanded indication. However, recent studies have shown a high incidence of lymph node metastasis in those meeting the expanded criteria. The aim of this stud...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4308-z

    authors: Eom BW,Yu JS,Ryu KW,Kook MC,Kim YI,Cho SJ,Lee JY,Kim CG,Choi IJ,Yoon HM,Kim YW

    更新日期:2015-01-01 00:00:00

  • Macrophage inflammatory protein-2 promotes angiogenesis, cell migration, and tumor growth in hepatic metastasis.

    abstract:BACKGROUND:In a mouse model of hepatic metastasis, we herein analyzed whether the CXC chemokine macrophage inflammatory protein (MIP)-2, a functional analogue of the human interleukin 8, stimulates tumor cell migration in vitro and angiogenesis and tumor growth in vivo. METHODS:By using chemotaxis chambers, CT26.WT co...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2006.03.096

    authors: Kollmar O,Scheuer C,Menger MD,Schilling MK

    更新日期:2006-02-01 00:00:00

  • Follow-Up Recommendations after Diagnosis of Primary Cutaneous Melanoma: A Population-Based Study in New South Wales, Australia.

    abstract:BACKGROUND:Follow-up practices after diagnosis and treatment of primary cutaneous melanoma vary considerably. We aimed to determine factors associated with recommendations for follow-up setting, frequency, skin surveillance, and concordance with clinical guidelines. METHODS:The population-based Melanoma Patterns of Ca...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6319-z

    authors: Read RL,Madronio CM,Cust AE,Goumas C,Watts CG,Menzies S,Curtin AM,Mann G,Thompson JF,Morton RL

    更新日期:2018-03-01 00:00:00

  • Laparoscopic versus open surgery for rectal cancer: a meta-analysis.

    abstract:BACKGROUND:Laparoscopic rectal cancer surgery aims to provide patients with curative resection while minimizing postoperative morbidity and mortality. This study used meta-analytical techniques to compare laparoscopic and open surgery as the primary treatment for patients with rectal cancer with regard to short-term an...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/ASO.2006.05.045

    authors: Aziz O,Constantinides V,Tekkis PP,Athanasiou T,Purkayastha S,Paraskeva P,Darzi AW,Heriot AG

    更新日期:2006-03-01 00:00:00

  • Impact of Neoadjuvant Chemotherapy on Clinical Risk Scores and Survival in Patients with Colorectal Liver Metastases.

    abstract:BACKGROUND:Several clinical risk scores for patients with colorectal liver metastases (CLM) were established in cohorts of patients undergoing liver resection (LR) without neoadjuvant chemotherapy (NAC). The purpose of the study was to evaluate the predictive values of four common risk scores in the setting of NAC and ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5615-3

    authors: Wimmer K,Schwarz C,Szabo C,Bodingbauer M,Tamandl D,Mittlböck M,Kaczirek K

    更新日期:2017-01-01 00:00:00

  • Toward optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer.

    abstract:BACKGROUND:Near-infrared (NIR) fluorescent sentinel lymph node (SLN) mapping in breast cancer requires optimized imaging systems and lymphatic tracers. MATERIALS AND METHODS:A small, portable version of the FLARE imaging system, termed Mini-FLARE, was developed for capturing color video and two semi-independent channe...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1566-x

    authors: Mieog JS,Troyan SL,Hutteman M,Donohoe KJ,van der Vorst JR,Stockdale A,Liefers GJ,Choi HS,Gibbs-Strauss SL,Putter H,Gioux S,Kuppen PJ,Ashitate Y,Löwik CW,Smit VT,Oketokoun R,Ngo LH,van de Velde CJ,Frangioni JV,Vahrme

    更新日期:2011-09-01 00:00:00

  • Recent experience with Wilms' tumor: 1978-1991.

    abstract:BACKGROUND:The treatment of Wilms' tumor has undergone major advances in the past four decades. Current therapy is based on both the stage and pathology of the tumor. We have reviewed our recent experience with this tumor to assess the results of treatment on protocols that generally avoid the use of doxorubicin. METH...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303542

    authors: Shamberger RC,Macklis RM,Sallan SE

    更新日期:1994-01-01 00:00:00

  • Tumor proximity to the recurrent laryngeal nerve in patients with primary hyperparathyroidism undergoing parathyroidectomy.

    abstract:BACKGROUND:Recurrent laryngeal nerve (RLN) injury is a rare complication for patients undergoing neck exploration for primary hyperparathyroidism (pHPT). Distances between RLNs and parathyroid adenomas have not been previously published. In this study we used a RLN monitor to identify the RLN and to measure the proximi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2495-z

    authors: Untch BR,Adam MA,Danko ME,Barfield ME,Dixit D,Scheri RP,Olson JA

    更新日期:2012-11-01 00:00:00

  • Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma.

    abstract:BACKGROUND:There is increasing evidence that tumor hypoxia plays a significant role in the chemoresistance of melanoma, but to our knowledge, real-time tumor oxygenation during isolated limb infusion (ILI) has not been studied. We sought to demonstrate the feasibility of measuring real-time alterations in tissue oxygen...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3222-0

    authors: Speicher PJ,Beasley GM,Jiang B,Lidsky ME,Palmer GM,Scarbrough PM,Mosca PJ,Dewhirst MW,Tyler DS

    更新日期:2014-05-01 00:00:00

  • CpG island methylator phenotype associated with tumor recurrence in tumor-node-metastasis stage I hepatocellular carcinoma.

    abstract:BACKGROUND:CpG island methylator phenotype (CIMP), characterized by simultaneous methylation of multiple tumor suppressor genes (TSGs), has been reported to be associated with biological malignancy in many cancers. Whether CIMP is potentially predictive of clinical outcome in hepatocellular carcinoma (HCC) remains unkn...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0921-7

    authors: Li B,Liu W,Wang L,Li M,Wang J,Huang L,Huang P,Yuan Y

    更新日期:2010-07-01 00:00:00

  • miR-196a overexpression and miR-196a2 gene polymorphism are prognostic predictors of oral carcinomas.

    abstract:BACKGROUND:Oral squamous cell carcinoma (OSCC) is prevalent worldwide, and survival in OSCC has not improved significantly in the last few decades. MicroRNAs have an important regulatory role in oral carcinogenesis. This study investigated the prognostic implications of miR-196 expression and the rs11614913 genotype of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2618-6

    authors: Liu CJ,Tsai MM,Tu HF,Lui MT,Cheng HW,Lin SC

    更新日期:2013-12-01 00:00:00

  • Anaplastic thyroid carcinoma: biology, pathogenesis, prognostic factors, and treatment approaches.

    abstract:BACKGROUND:Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors known to affect humans and carries a dismal prognosis. Our primary aim was to review its epidemiology, biology, risk factors, and prognostic indicators. We also reviewed the individual and combined roles of surgery, radiotherapy, c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/ASO.2006.05.042

    authors: Are C,Shaha AR

    更新日期:2006-04-01 00:00:00

  • Arteriolovenular shunting critically determines shutdown of microcirculation upon cryotherapy in tumor-bearing rat liver.

    abstract:BACKGROUND:Tissue destruction by cryosurgery not only is mediated by direct cell damage, but also involves secondary mechanisms, such as ischemia due to shutdown of the microcirculation. Clinicians favor repetitive cryoapplication, although there is no proven evidence for a more effective tumor eradication. METHODS:Th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2005.04.014

    authors: Richter S,Pistorius G,Seidel R,Feifel G,Schilling MK,Vollmar B,Menger MD

    更新日期:2005-04-01 00:00:00

  • The 2014 Society of Surgical Oncology Susan G. Komen for the Cure Symposium: triple-negative breast cancer.

    abstract::Triple-negative breast cancer (TNBC) is an operational term that refers to a heterogeneous collection of breast cancers lacking expression of estrogen receptor (ER), progesterone receptor, and HER2. These tumors account for 12-17 % of all breast cancers, preferentially affect young women, are more frequent in women of...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-014-4279-0

    authors: Newman LA,Reis-Filho JS,Morrow M,Carey LA,King TA

    更新日期:2015-03-01 00:00:00

  • Barriers to the Interpretation of Body Composition in Colorectal Cancer: A Review of the Methodological Inconsistency and Complexity of the CT-Defined Body Habitus.

    abstract:BACKGROUND:Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been identified as predictive of survival in colorectal cancer (CRC). We performed a systematic review of contemporary studies to characterize this association and highl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-018-6395-8

    authors: Hopkins JJ,Skubleny D,Bigam DL,Baracos VE,Eurich DT,Sawyer MB

    更新日期:2018-05-01 00:00:00

  • A Population-Based Analysis of Three Treatment Modalities for Malignant Obstruction of the Proximal Colon: Acute Resection Versus Stent or Stoma as a Bridge to Surgery.

    abstract:BACKGROUND:Malignant obstruction of the proximal colon (MOPC) traditionally has been treated with acute resection. However, morbidity and mortality rates following these emergency surgeries are high. Initial bowel decompression by stent placement or stoma construction has been used for distal obstructions as an alterna...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5247-7

    authors: Amelung FJ,Consten ECJ,Siersema PD,Tanis PJ

    更新日期:2016-10-01 00:00:00

  • High expression of AT-rich interactive domain 3A (ARID3A) is associated with good prognosis in colorectal carcinoma.

    abstract:BACKGROUND:AT-rich interactive domain 3A (ARID3A) is a member of the ARID family of DNA-binding proteins. Previous reports have shown that ARID3A controls cell growth in a p53-dependent manner. Recently, it has been reported that expression of the ARID3A protein was markedly increased in colon cancer tissue compared wi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-3435-2

    authors: Song M,Kim H,Kim WK,Hong SP,Lee C,Kim H

    更新日期:2014-12-01 00:00:00

  • The association of surgical margins and local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy: a meta-analysis.

    abstract:PURPOSE:There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We systematically review the evidence on surgical margins in BCT for invasive breast cancer to support the development of clinical guidelines. METHODS:Study-level meta-analysis of studies reporting local rec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-014-3480-5

    authors: Houssami N,Macaskill P,Marinovich ML,Morrow M

    更新日期:2014-03-01 00:00:00

  • A novel assay to assess the effectiveness of antiangiogenic drugs in human breast cancer.

    abstract:BACKGROUND:Many cytotoxic drugs maintain antiangiogenic properties, but there are no human, tumor-based assays to evaluate their antiangiogenic potential. We used a fibrin-thrombin clot-based angiogenesis model to evaluate the angiogenic response of human breast cancer to various cytotoxic agents commonly used in its t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0145-2

    authors: Lyons JM 3rd,Anthony CT,Thomson JL,Woltering EA

    更新日期:2008-12-01 00:00:00

  • Pseudoangiomatous stromal hyperplasia and breast cancer risk.

    abstract:BACKGROUND:Pseudoangiomatous stromal hyperplasia (PASH) is a benign localized fibrotic lesion in which clusters of spindle cells form cleftlike spaces, resembling ectatic vessels. Its relationship to breast cancer risk has not been characterized. MATERIALS AND METHODS:Histological presence of PASH was evaluated by rev...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1170-5

    authors: Degnim AC,Frost MH,Radisky DC,Anderson SS,Vierkant RA,Boughey JC,Pankratz VS,Ghosh K,Hartmann LC,Visscher DW

    更新日期:2010-12-01 00:00:00

  • Postchemoradiation resected locally advanced esophageal and gastroesophageal junction carcinoma: long-term outcome with or without intraoperative radiotherapy.

    abstract:BACKGROUND:To report feasibility, tolerance, anatomical topography of locoregional recurrence (LRR), and long-term outcome for esophageal and esophagogastric (EG) cancer patients treated with preoperative chemoradiation (CRT) and surgery with or without a radiation boost of intraoperative electron beam radiotherapy (IO...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2810-8

    authors: Calvo FA,Sole CV,Obregón R,Gómez-Espí M,Lozano MA,Gonzalez-Bayon L,García-Sabrido JL

    更新日期:2013-06-01 00:00:00

  • The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases.

    abstract:BACKGROUND:The prognosis of patients with esophageal squamous-cell cancer (ESCC) and multiple lymph-node metastases is quite poor. We examined whether neoadjuvant chemoradiation therapy (CRT) has a beneficial effect in such patients. METHODS:A total of 50 consecutive patients with T3-4 tumors and without organ metasta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3688-4

    authors: Okumura H,Uchikado Y,Omoto I,Kita Y,Sasaki K,Arigami T,Uenosono Y,Matsushita D,Hiraki Y,Owaki T,Ishigami S,Natsugoe S

    更新日期:2014-09-01 00:00:00

  • Pleural extension of mucinous tumor in patients with pseudomyxoma peritonei syndrome.

    abstract:BACKGROUND:Pseudomyxoma peritonei syndrome is a rare disease arising from perforation of an adenoma of the appendix. The syndrome is characterized by progressive accumulation of mucinous fluid and tumor within the abdomen and pelvis. Although this tumor is only superficially invasive and does not metastasize, it is a f...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02523654

    authors: Pestieau SR,Esquivel J,Sugarbaker PH

    更新日期:2000-04-01 00:00:00