Abstract:
BACKGROUND:Typically, studies investigating those at clinical high risk for psychosis have focused on predictors of conversion and treatments that might prevent conversion to full-blown psychosis. Few studies have followed those who do not go on to develop a psychotic illness. METHODS:Participants were 48 young people who were at risk for developing psychosis based on the Structured Interview for Prodromal Symptoms criteria and participated in a treatment programme where they were offered up to 6 months of psychosocial treatment and psychiatric management. Attenuated psychotic symptoms, negative symptoms, depression, anxiety, social functioning, alcohol and drug use, and meta-cognitive beliefs were assessed at baseline, 6, 12 and 18 months. Personality characteristics were assessed at baseline. Medication use was tracked and psychiatric visits were logged over the 18-month study period. RESULTS:On average, participants attended 12 sessions of psychosocial treatment and had one meeting with the psychiatrist every 6 months. Only 24% were ever prescribed any psychotropic medications, and antipsychotics were not used. Significant improvements were found over time in attenuated positive symptoms, negative symptoms, depression, anxiety, meta-cognitions and social functioning with most improvement occurring in the first 6 months. There was no change in the level of substance use. For personality assessment, participants generally scored high on neuroticism and openness and had low scores on extraversion, agreeableness and conscientiousness. CONCLUSION:With minimal treatment and no antipsychotics, young people who present as being at risk for developing a psychotic disorder demonstrate clinical improvement over time. However, a few continued to have the liability of ongoing attenuated psychotic symptoms.
journal_name
Early Interv Psychiatryjournal_title
Early intervention in psychiatryauthors
Marshall C,Addington J,Epstein I,Liu L,Deighton S,Zipursky RBdoi
10.1111/j.1751-7893.2011.00299.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
60-8issue
1eissn
1751-7885issn
1751-7893journal_volume
6pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Both the nature and number of a wide range of prodromal symptoms have been related to the severity and type of psychopathology in the psychotic phase. However, at present there is an incomplete picture focused mainly on the positive pre-psychotic dimension. AIM:To characterize the prodromal phase retrospect...
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journal_title:Early intervention in psychiatry
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journal_title:Early intervention in psychiatry
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更新日期:2011-11-01 00:00:00
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journal_title:Early intervention in psychiatry
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journal_title:Early intervention in psychiatry
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journal_title:Early intervention in psychiatry
pub_type: 杂志文章,随机对照试验
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journal_title:Early intervention in psychiatry
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更新日期:2017-06-01 00:00:00
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journal_title:Early intervention in psychiatry
pub_type: 杂志文章
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journal_title:Early intervention in psychiatry
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00300.x
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abstract:AIM:This study investigated the behavioural correlates of caregiver attitudes among parents of youth at risk for psychosis and with recent-onset psychotic symptoms. METHODS:Forty adolescents identified as ultra-high-risk (UHR) for psychosis using the Structured Interview for Prodromal Syndromes, and their primary care...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2008.00088.x
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journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12535
更新日期:2018-08-01 00:00:00
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