Cobalamin as coenzyme: a twisting trail of research.

Abstract:

:Cobalamin derivatives serve as coenzymes for the body's two cobalamin-dependent enzymes--adenosylcobalamin-dependent methylmalonyl CoA mutase, and methylcobalamin-dependent methionine methyltransferase. This essay reviews, in brief form and in personal terms, the history, beginning in the mid-1950s, of how these enzymes and coenzymes were discovered and what has been learned of their reaction mechanisms. It is clear that because of the fragility of the unique carbon-cobalt bond in cobalamin coenzymes, they serve primarily as free radical formers. This accounts for their efficiency in abstracting hydrogen from substrate molecules and for a subsequent chain of events that results in the isomerization of methylmalonyl CoA, the transfer of methyl groups, and (in certain bacteria) the reduction of ribonucleotides. Some thoughts are offered on the possible evolutionary significance of these facts.

journal_name

Am J Hematol

authors

Beck WS

doi

10.1002/ajh.2830340203

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

83-9

issue

2

eissn

0361-8609

issn

1096-8652

journal_volume

34

pub_type

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