Abstract：
:The hydration and swelling properties of the tablets made of chitosan, carboxymethyl starch, and a polyelectrolyte complex of these two polysaccharides have been studied by NMR imaging. We studied the effect of pH and ionic strength on the swelling of the tablets and on the diffusion of fluid into the tablets in water and simulated physiological fluids. The pH value of the fluids exerts a more significant effect than their ionic strengths on the swelling of the tablets. The tablets are compared also with those made of cross-linked high amylose starch. The formation of complex helps to keep the integrity of the tablets in various media and render a slow and restricted swelling similar to that of the tablets of the cross-linked high amylase starch, which is significantly lower than the swelling of chitosan and of carboxymethyl starch. The capacities to modulate the release rate of drugs in different media are discussed by comparing the matrices and evaluating the preparation process of the complex. A sustained release of less soluble drugs such as aspirin in gastrointestinal fluids can be provided by the complex, due to the ionic interaction and hydrogen bonding between the drug and the biopolymer complex.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Wang YJ,Assaad E,Ispas-Szabo P,Mateescu MA,Zhu XXdoi
10.1016/j.ijpharm.2011.08.008subject
Has Abstractpub_date
2011-10-31 00:00:00pages
215-21issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)00770-8journal_volume
419pub_type
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