Abstract:
BACKGROUND:Therapeutic hypothermia improves neurologic outcomes in patients resuscitated from cardiac arrest due to ventricular fibrillation. However, its role in patients with cardiac arrest due to non-shockable rhythms (pulseless electrical activity (PEA) and asystole) is unclear. We hypothesized that therapeutic hypothermia favorably impacts neurologic outcome and survival in patients resuscitated from cardiac arrest due to non-shockable rhythms. METHODS:Retrospectively collected data on consecutive adult patients admitted to Hartford Hospital from 1/1/2004 to 11/1/2010 who survived a cardiac arrest due to PEA or asystole were analyzed. Patients who underwent therapeutic hypothermia (1/1/2007-11/1/2010) formed the hypothermia group while patients admitted prior to the institution of therapeutic hypothermia (1/1/2004-1/1/2007) at Hartford Hospital formed the control group. The primary end-point was measured using the Pittsburgh cerebral performance category (CPC) scale and patients were assessed for a good (CPC 1 and 2) or poor (CPC 3-5) neurological outcome prior to discharge from hospital. A secondary end-point was measured as survival at discharge from hospital. RESULTS:Of 100 post-cardiac arrest patients included in the study, 15/52 (29%) patients in the hypothermia group had a good neurologic outcome as compared to 5/43 (10%) patients in the control group (P=0.021). On multivariate analysis, the odds ratio for good neurologic outcome and survival at discharge from the hospital with therapeutic hypothermia as compared to control were 4.35 (95% CI 1.10-17.24, P=0.04) and 5.65 (CI 1.66-19.23, P=0.006) respectively. CONCLUSION:Therapeutic hypothermia is associated with favorable neurologic outcome and survival in patients resuscitated after cardiac arrest due to non-shockable rhythms.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Lundbye JB,Rai M,Ramu B,Hosseini-Khalili A,Li D,Slim HB,Bhavnani SP,Nair SU,Kluger Jdoi
10.1016/j.resuscitation.2011.08.005subject
Has Abstractpub_date
2012-02-01 00:00:00pages
202-7issue
2eissn
0300-9572issn
1873-1570pii
S0300-9572(11)00482-5journal_volume
83pub_type
杂志文章相关文献
RESUSCITATION文献大全abstract:BACKGROUND:Patients undergoing orthopedic surgery are at risk of post-operative complications and needing Medical Emergency Team (MET) review. We assessed the frequency of, and associations with MET calls in orthopedic patients, and whether this was associated with increased in-hospital morbidity and mortality. METHOD...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.12.006
更新日期:2020-12-24 00:00:00
abstract:AIM OF THE STUDY:To compare the preferences of patients who survived resuscitation with those admitted as emergency cases about whether family members should be present during resuscitation. METHODS:We used a case control design and recruited, from four large hospitals, 21 survivors of resuscitation and 40 patients ad...
journal_title:Resuscitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.resuscitation.2009.05.020
更新日期:2009-09-01 00:00:00
abstract::Cardiopulmonary homeostasis for the high risk surgical patient is dependent on invasive monitoring techniques which are designed to allow for the early detection of physiological dysfunction during the development stages. One must maintain both minimum and maximum predetermined cardiorespiratory values by the early ut...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(84)90014-5
更新日期:1984-03-01 00:00:00
abstract:AIM:Each minute is crucial in the treatment of out-of-hospital cardiac arrest (CA). Immediate chest compressions and early defibrillation are keys to good outcomes. We hypothesized that a coordinated effort of alerting trained local neighborhood volunteers (vols) simultaneously with 911 activation of professional EMS p...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.09.016
更新日期:2019-11-01 00:00:00
abstract:AIM:Besides supportive care, the only recommended treatment for comatose patients after cardiac arrest is target temperature management. Helium reduces ischaemic injury in animal models, and might ameliorate neurological injury in patients after cardiac arrest. As no studies exist on the use of helium in patients after...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2016.07.004
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:System-based improvements to the chain of survival have yielded increases in survival from out-of-hospital cardiac arrest (OHCA) in adults. Comparatively little is known about the long-term trends in incidence and survival following paediatric OHCA. METHODS:Between 2000 and 2016, we included children aged ≤...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.04.030
更新日期:2018-07-01 00:00:00
abstract::Using the stable xenon-enhanced computed tomography (Xe-CT) method in dogs, we studied local, regional and global cerebral blood flow (LCBF, rCBF and gCBF) in two sham experiments and nine cardiac arrest experiments. Within the same experiments without arrest, gCBF and rCBF values were reproducible and stable. LCBF va...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(92)90171-8
更新日期:1992-08-01 00:00:00
abstract:AIM:In order to elucidate the factors for willingness to perform CPR, we evaluated the responses of college students to questionnaires before and after basic life support (BLS) training. METHODS:Before and after participating in a small group BLS course, 259 students completed questionnaires. A logistic regression mod...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2008.11.023
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:A large proportion of cardiac arrests outside hospital are caused by ventricular fibrillation. Although it is frequently used, the exact role for treatment with lidocaine in these patients remains to be determined. AIM:To describe the proportion of patients with witnessed out-of-hospital cardiac arrest foun...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(96)01018-0
更新日期:1997-01-01 00:00:00
abstract::In a prospective randomised study we investigated end-tidal carbon dioxide levels during standard versus active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) assuming that the end-tital carbon dioxide reflects cardiac output during resuscitation. In each group 60 patients with out-of-hospital car...
journal_title:Resuscitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0300-9572(98)00106-3
更新日期:1998-10-01 00:00:00
abstract::Up to 90% of cardiac arrests are due to acute myocardial infarction or severe myocardial ischaemia. Thrombolysis is an effective treatment for ST-elevation myocardial infarction (STEMI), but there is no evidence or guideline to put forward a thrombolysis strategy during cardiopulmonary resuscitation (CPR). In two phys...
journal_title:Resuscitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.resuscitation.2007.07.012
更新日期:2008-02-01 00:00:00
abstract::The endothelium releases vasoactive substances in response to several circulating hormones and to changes in shear stress of the flowing blood across the endothelial surface. Because the distribution of receptors mediating the release of endothelium-derived factors is not uniform along the vascular bed, the vascular e...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/0300-9572(89)90019-1
更新日期:1989-12-01 00:00:00
abstract:AIM:Emergency cardiopulmonary bypass (E-CPB) is an advanced and rarely used procedure for patients in cardiac arrest that do not regain restoration of spontaneous circulation with standard resuscitation methods. The feasibility, safety and outcome of the intervention with E-CPB in cardiac arrest situations at our depar...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.05.029
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:Mild therapeutic hypothermia (TH) has been shown to improve neurologic outcome in patients experiencing cardiac arrest after return of spontaneous circulation (ROSC). The best timing to initiate TH is currently not known. The aim of this study by the ICE (Italian Cooling Experience) group was to investigate ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2011.12.002
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:For prolonged VF, perfusion of the myocardium by pre-shock chest compressions can improve myocardial readiness for successful defibrillation. Characteristics of the VF waveform correlate with the duration of VF when there is no structural heart disease. A "smart" automated external defibrillator (AED) could ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.10.017
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:It is still under debate whether a period of cardiopulmonary resuscitation should be performed prior to rhythm analysis for defibrillation for out of hospital cardiac arrests (OHCA). This study compared outcomes of OHCA treated by "compression first" (CF) versus "analyze first" (AF) strategies in an Asian co...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2012.01.009
更新日期:2012-07-01 00:00:00
abstract:AIM:To determine the number of CPR trained adults in Sweden, and the willingness of the non-trained population to attend a CPR course. An additional purpose was to investigate differences related to sex, age, residential area, socio-economic classification and country of origin. METHODS:Five thousand adults in Sweden ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.11.009
更新日期:2006-07-01 00:00:00
abstract::Recent reports examining regional blood flow during cardiopulmonary resuscitation (CPR) have been criticized for several reasons: (1) cardiac arrest times of 5 min or less are not reflective of the prehospital setting, (2) anesthetic agents may significantly influence autonomic control of regional blood flow, (3) cani...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(88)90075-5
更新日期:1988-04-01 00:00:00
abstract:INTRODUCTION:The neutrophil lymphocyte ratio(NLR) is a marker of systemic inflammation. We hypothesized that admission NLR is related to mortality and that epinephrine application during resuscitation influences NLR in patients after successful resuscitation from out of hospital cardiac arrest (OHCA). METHODS:This ret...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2017.05.006
更新日期:2017-07-01 00:00:00
abstract::Little information has been published on the uptake of cardiopulmonary resuscitation (CPR) training in rural areas or on the potential to associate a health promotion message with skills training. This paper describes CPR instructor and community training programmes in Ireland. Public interest in these programmes has ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(96)01005-2
更新日期:1996-12-01 00:00:00
abstract::Transthoracic impedance (TTI) is an important determinant of success in defibrillation. Low TTI increases transmyocardial current and therefore increases the chance of depolarising a critical mass of myocardium. A major component of TTI occurs at the paddle-skin interface and is minimised by pressure applied to the de...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(01)00420-8
更新日期:2001-12-01 00:00:00
abstract:INTRODUCTION:Electroencephalogram (EEG) background reactivity is a potentially interesting outcome predictor in comatose patients, especially after cardiac arrest, but recent studies report only fair interrater reliability. Furthermore, there are no definite guidelines for its testing. We therefore investigated the EEG...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2015.09.380
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Therapeutic hypothermia has been associated with improved outcomes in term infants particularly in those who present with moderate hypoxic-ischemic encephalopathy (HIE). However, in the three major studies the time to initiate cooling was at approximately 4.5 postnatal hours. OBJECTIVE:To determine in term ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2010.08.001
更新日期:2010-12-01 00:00:00
abstract:INTRODUCTION:Defibrillation of patients connected to medical equipment that is not defibrillation proof risks ineffective defibrillation and harm to the operator as a result of aberrant electrical pathways taken by the defibrillation current. Many renal dialysis systems are not currently defibrillation proof. Although ...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/j.resuscitation.2006.10.012
更新日期:2007-06-01 00:00:00
abstract::It has been reported that total hypothermic blood exchange holds promise for the treatment of septic shock in animals. Since this procedure does not carry any mortality in out laboratory, we studied its effect in an acute septic shock model. After the intravenous injection of endotoxin (10 mg/kg) and blood transfusion...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(79)90030-3
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Within Europe and North America, the median annual mortality from snow avalanches between 1994 and 2003 was 141. There are two commonly used rescue devices: the avalanche transceiver, which is intended to speed up locating a completely buried person, and the avalanche airbag, which aims to prevent the person...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2007.06.002
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Cardiac arrest (CA) without return of spontaneous circulation can be treated with veno-arterial extracorporeal membrane oxygenation (vaECMO) implemented surgically or percutaneously. We performed a study assessing time for vaECMO percutaneous cannulation in the catheterization laboratory. METHODS:Single-cen...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2017.11.057
更新日期:2018-01-01 00:00:00
abstract::A previously asymptomatic 15-year-old boy was treated at our institution after an episode of chest pain, palpitation, and syncope while playing in a high school soccer game. The patient's resting electrocardiogram was normal. A transthoracic echocardiogram showed an anomalous left main coronary artery originating from...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2006.11.012
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:Out-of-hospital cardiac arrest (OHCA) at home is associated with lower rates of shockable initial rhythm and survival than OHCA in a public location. We determined whether medical history and medication use explain the association between OHCA location and presence of shockable initial rhythm and survival ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.03.011
更新日期:2020-06-01 00:00:00
abstract::Intracerebral temperatures of 15 degrees C have been achieved in 20 canine brains using a simple cannulation of the carotid arteries and interposition of a highly efficient heat exchanger. The appropriate changes in cardiovascular function and cerebral electrical activities have been documented. The extracorporeal sys...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(83)90008-4
更新日期:1983-02-01 00:00:00