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Weighting aligned protein or nucleic acid sequences to correct for unequal representation.

Abstract：

:Aligned sequences from the same family (e.g. the haemoglobins) are seldom representative of the entire family. This is because (1) the sequence databases are heavily skewed toward a small number of organisms and (2) only a minute fraction of all the different family members have been sequenced. For many applications, such as using alignments or profiles to perform database searches for distantly related family members, such unequal representation requires correction. An algorithm to perform appropriate weighting of individual sequences is presented along with examples illustrating its efficacy.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Sibbald PR,Argos P

doi

10.1016/S0022-2836(99)80003-5

subject

Has Abstract

pub_date

1990-12-20 00:00:00

pages

813-8

issue

4

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(99)80003-5

journal_volume

216

pub_type

杂志文章

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