Neuroendocrine effects of interferon alpha 2-a in healthy human subjects.

Abstract:

:The acute effects of interferon alpha-2a (3 x 10 IU im) on catecholamine and immunoreactive beta endorphin plasma levels, cortisol serum levels and lymphocyte beta 2-adrenoceptor density were evaluated in ten healthy volunteers. Interferon induced a significant increase in plasma norepinephrine; there was an increased norepinephrine standing response, too. On the contrary, epinephrine standing response was reduced by interferon. Lymphocyte beta 2-adrenoceptors decreased significantly after interferon administration; dissociation constant of binding was unchanged. Cortisol serum levels increased significantly with respect to control test, whereas immunoreactive beta endorphin did not change. These results support the hypothesis of functional relationships between neuroendocrine and immune systems; moreover they may be useful in clinical trials given the administration of interferon alpha in an increasing number of diseases.

authors

Pende A,Musso NR,Vergassola C,Puppo F,Ioverno A,Criscuolo D,Indiveri F,Lotti G

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

67-72

issue

2

eissn

0393-974X

issn

1724-6083

journal_volume

4

pub_type

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