Abstract:
:How cell collectives move and deposit subunits within a developing embryo is a question of outstanding interest. In many cases, a chemotactic mechanism is employed, where cells move up or down a previously generated attractive or repulsive gradient of signalling molecules. Recent studies revealed the existence of systems with isotropic chemoattractant expression in the lateral line primordium of zebrafish. Here we propose a mechanism for a cell collective, which actively modulates an isotropically expressed ligand and encodes an initial symmetry breaking in its velocity. We derive a closed solution for the velocity and identify an optimal length that maximizes the tissues' velocity. A length dependent polar gradient is identified, its use for pro-neuromast deposition is shown by simulations and a critical time for cell deposition is derived. Experiments to verify this model are suggested.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Streichan SJ,Valentin G,Gilmour D,Hufnagel Ldoi
10.1088/1478-3975/8/4/045004subject
Has Abstractpub_date
2011-08-01 00:00:00pages
045004issue
4eissn
1478-3967issn
1478-3975pii
S1478-3975(11)79723-0journal_volume
8pub_type
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