Abstract:
:Studies of the relationship between Alzheimer's disease (AD) and polymorphism in the promoter region of Interleukin 6 (IL-6) -174 G/C have reported inconsistent results. To assess the association between IL-6 -174 G/C promoter polymorphism and AD risk, a meta-analysis containing 3,101 AD cases and 3,860 controls from 18 case-control studies was performed. There were 16 studies involving Europeans and 2 studies involving non-Europeans. The combined results showed significant differences in recessive model [CC versus GC + GG, odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.54-0.90] and heterozygote comparison (CC versus GC, OR = 0.76, 95% CI = 0.60-0.96) on the basis of all studies. On subgroup analysis by ethnicity, similarly significant differences in recessive model (CC versus GC + GG) were found in both Europeans and non-Europeans, but significant difference in heterozygote comparison (CC versus GC) was found only in non-Europeans. In conclusion, there were statistically significant differences in genotype distribution of IL-6 -174 G/C between AD cases and controls in recessive model (CC versus GC + GG). Genotype CC of IL-6 -174 G/C could decrease the risk of AD. Further studies with large sample size, especially in subgroup analysis, should be done.
journal_name
J Neuroljournal_title
Journal of neurologyauthors
Dai L,Liu D,Guo H,Wang Y,Bai Ydoi
10.1007/s00415-011-6164-0subject
Has Abstractpub_date
2012-03-01 00:00:00pages
414-9issue
3eissn
0340-5354issn
1432-1459journal_volume
259pub_type
杂志文章,meta分析,评审abstract::Out of 72 patients treated for Borrelia burgdorferi meningopolyradiculoneuritis facial palsies occurred in 22 (12 unilateral, 10 bilateral). Eleven of the 32 pareses were initially complete. By the follow-up examination patients had recovered well with slight sequelae in 22% without cosmetically disfiguring pareses or...
journal_title:Journal of neurology
pub_type: 杂志文章
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更新日期:1993-05-01 00:00:00
abstract::Report of a further case with coexisting diabetes mellitus, diabetes insipidus, optic atrophy und neurogenic deafness. It was not possible to find a cause for these symptoms. The cases reported in the literature are brought together and discussed. ...
journal_title:Journal of neurology
pub_type: 杂志文章
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abstract::Some clinical and experimental data suggest a possible role of gamma-aminobutyrate (GABA)-ergic mechanisms in the pathophysiology of essential tremor (ET), such as the improvement of ET with some GABAergic drugs and the development of an experimental model of ET in GABA A receptor alpha-1 knockout mice (postural and k...
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abstract::Natalizumab, an anti-alpha4 integrin antibody, significantly reduces the number of visibly enhancing multiple sclerosis (MS) lesions. In this substudy of a 2-year trial of natalizumab monotherapy versus placebo, contrast-enhanced imaging investigated for subtle blood brain barrier (BBB) leakage in relapsing remitting ...
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-002-0825-y
更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-019-09683-5
更新日期:2020-04-01 00:00:00
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更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00415-020-09782-8
更新日期:2020-07-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09971-5
更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-020-09956-4
更新日期:2020-10-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/BF00313465
更新日期:1981-01-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-006-0065-7
更新日期:2006-05-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-011-6176-9
更新日期:2012-02-01 00:00:00
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journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-018-9082-6
更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00313005
更新日期:1979-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s00415-011-6247-y
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doi:10.1007/s00415-010-5789-8
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pub_type: 杂志文章
doi:10.1007/s00415-011-6259-7
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF00313985
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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