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Proteomic analysis identified DJ-1 as a cisplatin resistant marker in non-small cell lung cancer.

Abstract：

:The aim of study is to identify cisplatin-resistance associated biomarkers for non-small cell lung cancers (NSCLC). We use two-dimensional electrophoresis (2-DE) combined with MALDI-TOF mass spectrometry to compare the proteome between lung cancer cell line A549 and its cisplatin-resistant subline A549/DDP. Nine cisplatin resistance-related proteins were identified, and DJ-1, one of the differently expressed proteins, was selected for further validation and evaluation. Immunohistochemical results demonstrated that high expression level of DJ-1 was associated with cisplatin resistance and a predictor for poor prognosis in 67 locally advanced NSCLC patients. Furthermore, in vitro results showed that silencing DJ-1 increased the proliferation inhibitory effect of cisplatin to A549/DDP cells. In conclusion, DJ-1 might play an important role in the resistibility to cisplatin, and it could also act as a novel candidate biomarker for predicting the response of NSCLC patients to cisplatin-based chemotherapy.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Zeng HZ,Qu YQ,Zhang WJ,Xiu B,Deng AM,Liang AB

doi

10.3390/ijms12063489

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

3489-99

issue

6

issn

1422-0067

pii

ijms-12-03489

journal_volume

12

pub_type

杂志文章

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