Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication.

Abstract:

:We tested the capsid targeted viral inactivation method as an anti-HBV strategy. HepG2 cells were cotransfected with HBV expression plasmid and the plasmid encoding fusion protein of either Core-A3C or Core-humanized renilla GFP (hrGFP). Core-A3C had substantial effect on HBV DNA levels. In the HepG2 cells expressing Core-A3C, the number of G-to-A mutations increased dramatically, whereas other nucleotide substitutions were rare. In addition, Core-A3C substantially inhibited HBV production intracellularly and in culture supernatant. These results suggest that Core-A3C may be a candidate as a novel antiviral agent against human HBV infection.

journal_name

J Biochem

journal_title

Journal of biochemistry

authors

Li D,Liu J,Kang F,Guan W,Gao X,Wang Y,Sun D

doi

10.1093/jb/mvr086

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

371-4

issue

4

eissn

0021-924X

issn

1756-2651

pii

mvr086

journal_volume

150

pub_type

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