Abstract：
:The use of adult stem cells for therapeutic purposes has met with great success in recent years. Among several types of adult stem cells, mesenchymal stem cells (MSCs) derived from bone marrow (BM) and other sources have gained popularity for basic research and clinical applications because of their therapeutic potential in treating a variety of diseases. Because of their tissue regeneration potential and immune modulation effect, MSCs were recently used as cell-based therapy to promote revascularization, increase pancreatic β-cell proliferation, and avoid allograft rejection in islet transplantation. Taking advantage of the recent progress in gene therapy, genetically modified MSCs can further enhance and expand the therapeutic benefit of primary MSCs while retaining their stem-cell-like properties. This review aims to gain a thorough understanding of the current obstacles to successful islet transplantation and discusses the potential role of primary MSCs before or after genetic modification in islet transplantation.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Wu H,Ye Z,Mahato RIdoi
10.1021/mp200135esubject
Has Abstractpub_date
2011-10-03 00:00:00pages
1458-70issue
5eissn
1543-8384issn
1543-8392journal_volume
8pub_type
杂志文章,评审abstract：:Deferoxamine mesylate (DFO) is an FDA-approved, hexadentate iron chelator routinely used to alleviate systemic iron burden in thalassemia major and sickle cell patients. Iron accumulation in these disease states results from the repeated blood transfusions required to manage these conditions. Iron accumulation has als...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.0c00474
更新日期：2021-02-01 00:00:00
abstract：:Nonviral transfections of six low passage human colon cancer cell lines using the artificial beta-catenin/TCF-dependent promoter CTP4 demonstrated a high promoter activity which was 1000- to 70000-fold higher than in HeLa control cells. Luciferase gene expression levels obtained with CTP4 in epithelial-like tumor cell...
journal_title：Molecular pharmaceutics
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更新日期：2007-01-01 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
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更新日期：2017-10-02 00:00:00
abstract：:The reaction of singlet oxygen with water to form hydrogen peroxide was catalyzed by antibodies and has been termed as the antibody catalyzed water oxidation pathway (ACWOP) (Nieva and Wentworth, Trends Biochem. Sci. 2004, 29, 274-278; Nieva et al. Immunol. Lett. 2006, 103, 33-38). While conserved and buried tryptopha...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
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更新日期：2013-01-07 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp3003495
更新日期：2012-11-05 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp100382m
更新日期：2011-06-06 00:00:00
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journal_title：Molecular pharmaceutics
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp300428p
更新日期：2013-03-04 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.8b00588
更新日期：2018-10-01 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章,评审
doi：10.1021/mp5007213
更新日期：2015-02-02 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.7b00662
更新日期：2017-12-04 00:00:00
abstract：:In vivo peptide inhibition of tumor suppressor p53 binding to the protein MDM2 is hampered by inefficient delivery of the peptide. Our approach to couple a hydrophobic lipid-like tail on the inhibitory peptide p53(14-29) allowed its intracellular delivery in vitro, in a panel of different cell lines. The constructed c...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp100193h
更新日期：2010-12-06 00:00:00
abstract：:A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecular structures gain most in solubility when dissolved under physiologically relevant conditions. Th...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp100049m
更新日期：2010-10-04 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.7b00568
更新日期：2017-10-02 00:00:00
abstract：:The purpose of the present study was to investigate the effect of seed particles on the precipitation behavior of weak base drugs in the small intestine. A simple in vitro infusion method was used to mimic in vivo processes. Dipyridamole, pioglitazone, topiroxostat, chlorpromazine, cinnarizine, and ketoconazole were u...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.6b00297
更新日期：2016-08-01 00:00:00
abstract：:We report on tailored lipid-polymer hybrid nanoparticles (NPs) delivering nitric oxide (NO) under the control of visible light as a tool for overcoming doxorubicin (DOX) resistance. The NPs consist of a polymeric core and a coating. They are appropriately designed to entrap DOX in the poly(lactide-co-glycolide) core a...
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pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.0c00290
更新日期：2020-06-01 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp500485w
更新日期：2015-01-05 00:00:00
abstract：:In order to gain molecular level understanding of drug dissolution into aqueous media, we report the first molecular dynamics (MD) simulation of a drug crystal dissolving. The simulation was performed for acetaminophen crystal Form I dissolving in 0.15 M aqueous NaCl solution at 37 °C. The 10 ns simulation revealed in...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp4000212
更新日期：2013-03-04 00:00:00
abstract：:Fenretinide, a chemotherapeutic agent for cancer, is water-insoluble and has a very low oral bioavailability. Hence, the objective was to deliver it as an injectable depot and improve the drug solubility and release behavior from poly(lactide-co-glycolide) (PLGA) microspheres by incorporating nonionic surfactants with...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.8b01001
更新日期：2019-03-04 00:00:00
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pub_type： 杂志文章
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更新日期：2018-09-04 00:00:00
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更新日期：2018-01-02 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
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更新日期：2014-01-06 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/mp800088f
更新日期：2009-01-01 00:00:00
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doi：10.1021/mp050035b
更新日期：2005-11-01 00:00:00
abstract：:Boron neutron capture therapy (BNCT) has received extensive attention as noninvasive cell-level oncotherapy for treating solid cancer tumors. However, boron-containing drugs such as l-boronophenylalanine (BPA) and sodium borocaptate have low boron content and/or poor tumor-targeting ability, limiting their application...
journal_title：Molecular pharmaceutics
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doi：10.1021/acs.molpharmaceut.9b00898
更新日期：2020-01-06 00:00:00
abstract：:Oxidative stress and inflammation are intertwined contributors to numerous acute vascular pathologies. A novel dual bioactive nanoparticle with antioxidant/anti-inflammatory properties was developed based on the interactions of tocopherol phosphate and the manganese porphyrin SOD mimetic, MnTMPyP. The size and drug in...
journal_title：Molecular pharmaceutics
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doi：10.1021/mp400677y
更新日期：2014-07-07 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
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更新日期：2017-09-05 00:00:00
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journal_title：Molecular pharmaceutics
pub_type： 杂志文章
doi：10.1021/acs.molpharmaceut.0c00103
更新日期：2020-05-04 00:00:00
abstract：:A wide variety of chemotherapy and radiotherapy agents are available for treating cancer, but a critical challenge is to deliver these agents locally to cancer cells and tumors while minimizing side effects from systemic delivery. Nanomedicine uses nanoparticles with diameters in the range of ∼1-100 nm to encapsulate ...
journal_title：Molecular pharmaceutics
pub_type： 杂志文章,评审
doi：10.1021/mp400419k
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