当前位置： SCI文献检索 > NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY期刊下所有文献 > Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis.

Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis.

Abstract：

AIMS:Phosphorylated TDP-43 (pTDP-43) is the pathological protein responsible for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Recently, it has been reported that accumulation of pTDP-43 can occur in the brains of patients with argyrophilic grain disease (AGD), in which phosphorylated 4-repeat tau is the pathological protein. To elucidate the association of ALS with AGD, we examined the brains from 37 consecutively autopsied patients with sporadic ALS (age range 45-84 years, mean 71.5 ± 9.0 years). METHODS:Sections from the frontotemporal lobe were stained with the Gallyas-Braak method and also immunostained with antibodies against phosphorylated tau, 4-repeat tau and pTDP-43. RESULTS:Fourteen (38%) of the 37 ALS patients were found to have AGD. With regard to staging, 5 of these 14 cases were rated as I, 4 as II and 5 as III. pTDP-43 immunohistochemistry revealed the presence of positive neuronal and glial cytoplasmic inclusions in the affected medial temporal lobe in many cases (93% and 64%, respectively). On the other hand, pTDP-43-positive small structures corresponding to argyrophilic grains were observed only in one case. A significant correlation was found between AGD and the Braak stage for neurofibrillary pathology (stage range 0-V, mean 2.1). However, there were no significant correlations between AGD and any other clinicopathological features, including dementia. CONCLUSIONS:The present findings suggest that co-occurrence of AGD in ALS is not uncommon, and in fact comparable with that in a number of diseases belonging to the tauopathies or α-synucleinopathies.

journal_name

Neuropathol Appl Neurobiol

journal_title

Neuropathology and applied neurobiology

authors

Soma K,Fu YJ,Wakabayashi K,Onodera O,Kakita A,Takahashi H

doi

10.1111/j.1365-2990.2011.01175.x

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

54-60

issue

1

eissn

0305-1846

issn

1365-2990

journal_volume

38

pub_type

杂志文章

相关文献

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY文献大全
  • Cryopreservation of viable human glioblastoma xenografts.

    abstract：:Human tumour xenografts maintained in nude mice are a valuable research tool. The passaging and maintenance of human tumour xenografts in immune-deficient animals are expensive and labour-intensive. This study presents a protocol that permits long-term cryopreservation of viable glioblastoma xenograft tissue pieces in...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2000.026002172.x

    authors： Goike HM,Asplund AC,Pettersson EH,Liu L,Ichimura K,Collins VP

    更新日期：2000-04-01 00:00:00

  • Spinal manifestations of CLN1 disease start during the early postnatal period.

    abstract：AIM:To understand the progression of CLN1 disease and develop effective therapies we need to characterize early sites of pathology. Therefore, we performed a comprehensive evaluation of the nature and timing of early CLN1 disease pathology in the spinal cord, which appears especially vulnerable, and how this may affect...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12658

    authors： Nelvagal HR,Dearborn JT,Ostergaard JR,Sands MS,Cooper JD

    更新日期：2020-08-25 00:00:00

  • Neural tissue grafts and repair of the injured spinal cord.

    abstract：:Neural tissue grafting presently stands as one of the more intriguing experimental strategies being applied to the problem of spinal cord regeneration. The following annotation presents an overview of recent investigations which have shown: that peripheral nerve grafts can stimulate axonal outgrowth in many descending...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2990.1985.tb00007.x

    authors： Reier PJ

    更新日期：1985-03-01 00:00:00

  • The neuropathology, pathophysiology and genetics of multiple system atrophy.

    abstract：:Multiple system atrophy (MSA) is an unrelenting, sporadic, adult-onset, neurodegenerative disease of unknown aetiology. Its clinically progressive course is characterized by a variable combination of parkinsonism, cerebellar ataxia and/or autonomic dysfunction. Neuropathological examination often reveals gross abnorma...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2990.2011.01234.x

    authors： Ahmed Z,Asi YT,Sailer A,Lees AJ,Houlden H,Revesz T,Holton JL

    更新日期：2012-02-01 00:00:00

  • Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia.

    abstract：AIMS:Adult neurogenesis is well described in the subventricular zone of the lateral ventricle walls and in the subgranular zone of the hippocampal dentate gyrus. However, recent studies indicate that self-renewal of neural stem cells (NSCs) is not restricted to these niches, but that diverse areas of the adult brain ar...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2012.01301.x

    authors： Sanin V,Heeß C,Kretzschmar HA,Schüller U

    更新日期：2013-08-01 00:00:00

  • Human medulloblastomas lack point mutations and homozygous deletions of the hSNF5/INI1 tumour suppressor gene.

    abstract：:Medulloblastomas (MBs) are malignant primitive neuroectodermal tumours (PNETs) of the cerebellum occurring predominantly in childhood. The association of monosomy of chromosome 22 with MB is controversial. Atypical teratoid/rhabdoid tumours (AT/RTs) of the brain share clinical and histological features with MBs and su...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2002.00388.x

    authors： Kraus JA,Oster C,Sörensen N,Berthold F,Schlegel U,Tonn JC,Wiestler OD,Pietsch T

    更新日期：2002-04-01 00:00:00

  • Ex vivo study of dentate gyrus neurogenesis in human pharmacoresistant temporal lobe epilepsy.

    abstract：AIMS:Neurogenesis in adult humans occurs in at least two areas of the brain, the subventricular zone of the telencephalon and the subgranular layer of the dentate gyrus in the hippocampal formation. We studied dentate gyrus subgranular layer neurogenesis in patients subjected to tailored antero-mesial temporal resectio...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2010.01102.x

    authors： Paradisi M,Fernández M,Del Vecchio G,Lizzo G,Marucci G,Giulioni M,Pozzati E,Antonelli T,Lanzoni G,Bagnara GP,Giardino L,Calzà L

    更新日期：2010-10-01 00:00:00

  • Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis.

    abstract：AIMS:Clusterin is a topologically dynamic chaperone protein with the ability to participate in both intra- and extacellular proteostasis. Clusterin has been shown to be upregulated in the spinal cord of patients with amyotrophic lateral sclerosis (ALS) and has been shown to protect against TDP-43 protein misfolding in ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12575

    authors： Gregory JM,Elliott E,McDade K,Bak T,Pal S,Chandran S,Abrahams S,Smith C

    更新日期：2020-04-01 00:00:00

  • A case of Pelizaeus-Merzbacher disease showing increased dosage of the proteolipid protein gene.

    abstract：:Clinical, neuropathological and molecular genetic studies in a 9 month old boy with Pelizaeus-Merzbacher disease are described. The principal clinical features were developmental delay, nystagmus, stridor and seizures. Both brain and spinal cord showed almost complete absence of stainable central myelin, while cranial...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1995.tb01036.x

    authors： Harding B,Ellis D,Malcolm S

    更新日期：1995-04-01 00:00:00

  • The effects of pre-natal exposure to methylazoxymethanol acetate on microglia.

    abstract：:The effects of exposure to a cytotoxic agent, methylazoxymethanol acetate (MAM Ac), on the distribution, density and quantitative morphology of microglia in the rat forebrain have been examined with the aid of a peroxidase-conjugated lectin derived from Griffonia simplicifolia. Following exposure to MAM Ac (25 mg/kg m...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1992.tb00832.x

    authors： Ashwell KW

    更新日期：1992-12-01 00:00:00

  • Toll-like receptor-4-mediated autophagy contributes to microglial activation and inflammatory injury in mouse models of intracerebral haemorrhage.

    abstract：AIMS:Much evidence demonstrates that Toll-like receptor-4 (TLR4)-mediated microglial activation is an important contributor to the inflammatory injury in intracerebral haemorrhage (ICH). However, the exact mechanism of TLR4-mediated microglial activation induced by ICH is not clear. In addition, microglial autophagy is...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12177

    authors： Yang Z,Liu B,Zhong L,Shen H,Lin C,Lin L,Zhang N,Yuan B

    更新日期：2015-06-01 00:00:00

  • Heterozygous APOE Christchurch in familial Alzheimer's disease without mutations in other Mendelian genes.

    abstract：:We present the clinical and neuropathological findings of a patient with early onset Alzheimer's dementia (AD), heterozygous carrier of the rare Apolipoprotein E Christchurch (APOEch) variant. The patient did not harbor any pathogenic mutation in known Mendelian genes related to AD or other neurodegenerative disorders...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12670

    authors： Hernandez I,Gelpi E,Molina-Porcel L,Bernal S,Rodríguez-Santiago B,Dols-Icardo O,Ruiz A,Alcolea D,Boada M,Lleó A,Clarimón J

    更新日期：2020-10-23 00:00:00

  • A quantitative assessment of dystrophic mouse (129 ReJ dy/dy) myogenesis in vitro.

    abstract：:A quantitative assessment was made of the myogenic capability in vitro of muscle cells from dystrophic (129 Rej dy/dy) and normal mice from birth to 5 months old. Seeding efficiency was increased in dystrophic cells from neonatal and 1-week-old mice compared to age-matched controls. The extent of myogenesis in culture...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1981.tb00098.x

    authors： Summers PJ,Parsons R

    更新日期：1981-07-01 00:00:00

  • Membranous expression of glucose transporter-1 protein (GLUT-1) in embryonal neoplasms of the central nervous system.

    abstract：:The human erythrocyte GLUT-1 is a transmembrane protein which facilitates transport of glucose in the cell in an energy-independent fashion. Neuroectodermal stem cells show strong membrane immunoreactivitry with this marker at early developmental stages in rodents. Membranous expression by undifferentiated neuroectode...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.2000.00225.x

    authors： Loda M,Xu X,Pession A,Vortmeyer A,Giangaspero F

    更新日期：2000-02-01 00:00:00

  • Differential insular cortex subregional vulnerability to α-synuclein pathology in Parkinson's disease and dementia with Lewy bodies.

    abstract：AIM:The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease (PD) and dementia with Lewy bodies (DLB), it reveals α-synuclein pathology in advanced stages. The...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12501

    authors： Fathy YY,Jonker AJ,Oudejans E,de Jong FJJ,van Dam AW,Rozemuller AJM,van de Berg WDJ

    更新日期：2019-04-01 00:00:00

  • The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling.

    abstract：AIMS:Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGG...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12479

    authors： Catanzaro G,Besharat ZM,Miele E,Chiacchiarini M,Po A,Carai A,Marras CE,Antonelli M,Badiali M,Raso A,Mascelli S,Schrimpf D,Stichel D,Tartaglia M,Capper D,von Deimling A,Giangaspero F,Mastronuzzi A,Locatelli F,Ferrett

    更新日期：2018-12-01 00:00:00

  • Aluminium maltol-induced neurocytoskeletal changes in fetal rabbit midbrain in matrix culture.

    abstract：:We have developed a neuronal culture system to evaluate the neurotoxic effects of aluminium maltol on fetal rabbit midbrain sections containing the oculomotor nucleus. Cultures were treated with 5, 7, 9, 11, 13 and 15 mumol/l aluminium maltol or 39 and 45 mumol/l maltol (molal equivalents to 13 and 15 mumol/l aluminiu...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1991.tb00693.x

    authors： Hewitt CD,Herman MM,Lopes MB,Savory J,Wills MR

    更新日期：1991-02-01 00:00:00

  • Hypertrophic perineurial dysplasia in multifocal and generalized peripheral neuropathies.

    abstract：:Two cases are described, one with a multifocal cranial and limb neuropathy of adult onset associated with optic neuropathy, and the other with a diffuse demyelinating neuropathy characterized by congenital cataract, mental retardation and progressive lower limb paresis with an onset in childhood. Extensive investigati...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.0305-1846.2000.00289.x

    authors： Thomas PK,King RH,Workman JM,Schröder JM

    更新日期：2000-12-01 00:00:00

  • Immunohistochemical analysis of cyclin A in astrocytic tumours.

    abstract：:Cyclins are important regulators of the cell cycle; there is increasing evidence that some cyclins are positively involved in carcinogenesis. Amplification and translocation of the cyclin genes and overexpression of their mRNAs and proteins have been observed in a variety of tumours. We studied cyclin A protein in ast...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1998.00114.x

    authors： Chakrabarty A,Bridges LR

    更新日期：1998-06-01 00:00:00

  • Neuronal apoptosis in HIV infection in adults.

    abstract：:Productive infection of the central nervous system by HIV predominantly involves the white matter and basal ganglia. Involvement of the cerebral cortex with neuronal loss is also described in AIDS patients but not in asymptomatic HIV-positive patients. The mechanism of neuronal damage is unknown. To enquire whether ne...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1995.tb01053.x

    authors： Adle-Biassette H,Levy Y,Colombel M,Poron F,Natchev S,Keohane C,Gray F

    更新日期：1995-06-01 00:00:00

  • Expression of cellular adhesion molecule 'OPCML' is down-regulated in gliomas and other brain tumours.

    abstract：:The four GPI-anchored cell adhesion molecules that exemplify the IgLON family are most highly expressed in the nervous system and associate to form up to six different heterodimeric 'Diglons' that can modify cell adhesion and inhibit axon migration. Recently, two members, OPCML and LSAMP, were identified as putative t...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2006.00786.x

    authors： Reed JE,Dunn JR,du Plessis DG,Shaw EJ,Reeves P,Gee AL,Warnke PC,Sellar GC,Moss DJ,Walker C

    更新日期：2007-02-01 00:00:00

  • Microglial alterations in human Alzheimer's disease following Aβ42 immunization.

    abstract：AIMS:In Alzheimer's disease (AD), microglial activation prompted by the presence of amyloid has been proposed as an important contributor to the neurodegenerative process. Conversely following Aβ immunization, phagocytic microglia have been implicated in plaque removal, potentially a beneficial effect. We have investig...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.2010.01156.x

    authors： Zotova E,Holmes C,Johnston D,Neal JW,Nicoll JA,Boche D

    更新日期：2011-08-01 00:00:00

  • Purine metabolism gene deregulation in Parkinson's disease.

    abstract：AIMS:To explore alterations in the expression of genes encoding enzymes involved in purine metabolism in Parkinson's disease (PD) brains as purines are the core of the DNA, RNA, nucleosides and nucleotides which participate in a wide variety of crucial metabolic pathways. METHODS:Analysis of mRNA using real-time quant...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/nan.12221

    authors： Garcia-Esparcia P,Hernández-Ortega K,Ansoleaga B,Carmona M,Ferrer I

    更新日期：2015-12-01 00:00:00

  • Cocaine induces cell death within the primate fetal cerebral wall.

    abstract：:Transferase dUTP nick-end labelling (TUNEL) analysis was used to compare the occurrence of cell death in the cerebral wall of cocaine-exposed and drug-naïve monkey fetuses. The rhesus monkeys providing the drug-exposed fetuses received 10 mg/kg of cocaine orally (in fruit treats) in the morning and in the evening betw...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2990.1999.00211.x

    authors： He N,Song ZM,Lidow MS

    更新日期：1999-12-01 00:00:00

  • Review: low-grade gliomas as neurodevelopmental disorders: insights from mouse models of neurofibromatosis-1.

    abstract：:Over the past few years, the traditional view of brain tumorigenesis has been revolutionized by advances in genomic medicine, molecular biology, stem cell biology and genetically engineered small-animal modelling. We now appreciate that paediatric brain tumours arise following specific genetic mutations in specialized...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2990.2011.01230.x

    authors： Thangarajh M,Gutmann DH

    更新日期：2012-06-01 00:00:00

  • Review: Prion-like mechanisms of transactive response DNA binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis (ALS).

    abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal devastating neurodegenerative disorder which predominantly affects the motor neurons in the brain and spinal cord. The death of the motor neurons in ALS causes subsequent muscle atrophy, paralysis and eventual death. Clinical and biological evidence now demonstrates that ...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/nan.12206

    authors： Smethurst P,Sidle KC,Hardy J

    更新日期：2015-08-01 00:00:00

  • Spongiform encephalopathy: a neurocytologist's viewpoint with a note on Alzheimer's disease.

    abstract：:Ultrastructural studies of spongiform encephalopathy (SE) reveal no very early pathological changes in kuru where membrane lamellation has been reported. This observation is challenged. In the later stages of SE, two main theories are examined--the spiroplasma theory and the prion (6 nm filament) theory. Neither are s...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1986.tb00047.x

    authors： Gray EG

    更新日期：1986-03-01 00:00:00

  • Review: autophagy and neurodegeneration: survival at a cost?

    abstract：:Protein aggregation, mitochondrial impairment and oxidative stress are common to multiple neurodegenerative diseases. Homeostasis is regulated by a balanced set of anabolic and catabolic responses, which govern removal and repair of damaged proteins and organelles. Macroautophagy is an evolutionarily conserved pathway...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2990.2010.01062.x

    authors： Cherra SJ 3rd,Dagda RK,Chu CT

    更新日期：2010-04-01 00:00:00

  • Invited Review: Emerging functions of histone H3 mutations in paediatric diffuse high-grade gliomas.

    abstract：:Paediatric diffuse high-grade gliomas (pHGG) are rare, but deadly tumours. The discovery of recurrent mutations in the tail of histone H3, changing lysine 27 to methionine, or glycine 34 to arginine or valine, has illuminated a critical role for epigenetic dysregulation in the aetiology of childhood gliomas and opened...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章,评审

    doi：10.1111/nan.12591

    authors： Kasper LH,Baker SJ

    更新日期：2020-02-01 00:00:00

  • The cellular origin of lysosomal enzymes in the plaque in multiple sclerosis. II. A histochemical study with combined demonstration of myelin and acid phosphatase.

    abstract：:Existing techniques have been adapted and it has been possible to demonstrate acid phosphatase (APP) and myelin, lipid or astrocytic fibres in the same histological section. In normal controls APP was demonstrated in neurons, astrocytes, ependyma including choroid plexus epithelium and in pericytes, but not in oligode...

    journal_title：Neuropathology and applied neurobiology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2990.1979.tb00619.x

    authors： Allen IV,Glover G,McKeown SR,McCormick D

    更新日期：1979-05-01 00:00:00