Deficiency of PXR decreases atherosclerosis in apoE-deficient mice.

abstract：:Extracted tissue phospholipid 31P NMR profiles, obtained from individual porcine lenses subjected to two preservation procedures (acetone desiccation and freeze-drying) and a perchloric acid-extraction procedure, were compared to those from freshly excised lens specimens. Each profile yielded quantitative data on 12 l...

journal_title：Journal of lipid research

authors： Meneses P,Para PF,Glonek T

更新日期：1989-03-01 00:00:00

abstract：:The bioactive molecule sphingosine 1-phosphate (S1P) is abundantly stored in platelets and can be released extracellularly. However, although they have high sphingosine (Sph) kinase activity, platelets lack the de novo sphingolipid biosynthesis necessary to provide the substrates. Here, we reveal a generation pathway ...

journal_title：Journal of lipid research

authors： Tani M,Sano T,Ito M,Igarashi Y

更新日期：2005-11-01 00:00:00

abstract：:ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation impacts HDL functio...

journal_title：Journal of lipid research

authors： Huang L,Fan B,Ma A,Shaul PW,Zhu H

更新日期：2015-05-01 00:00:00

abstract：:Increased plasma concentrations of apolipoprotein A-IV (apoA-IV) in chronic renal disease suggest a metabolic role of the kidney for this antiatherogenic protein. Therefore, we investigated patients with various forms of proteinuria and found increased serum concentrations of apoA-IV in 124 nephrotic patients compared...

journal_title：Journal of lipid research

authors： Lingenhel A,Lhotta K,Neyer U,Heid IM,Rantner B,Kronenberg MF,König P,von Eckardstein A,Schober M,Dieplinger H,Kronenberg F

更新日期：2006-09-01 00:00:00

abstract：:Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expenditure in mice. Them1 is a putative fatty acyl-CoA thioesterase that comprises tandem hot dog-fold thioesterase domains and a lipid-binding C-terminal steroidogeni...

journal_title：Journal of lipid research

authors： Han S,Cohen DE

更新日期：2012-12-01 00:00:00

abstract：:We investigated the role of caveolae in uptake and intracellular trafficking of long chain fatty acids (LCFA) in HepG2 human hepatoma cells. The uptake of [(3)H]oleic acid and [(3)H]stearic acid into HepG2 cells was measured by radioactive assays and internalization of the non-metabolizable fluorescent fatty acid 12-(...

journal_title：Journal of lipid research

authors： Pohl J,Ring A,Stremmel W

更新日期：2002-09-01 00:00:00

abstract：:Plasma phospholipid transfer protein (PLTP) is an important regulator of plasma HDL levels and HDL particle distribution. PLTP is present in plasma in two forms, one with high and the other with low phospholipid transfer activity. We have used the human hepatoma cell line, HepG2, as a model to study PLTP secreted from...

journal_title：Journal of lipid research

authors： Siggins S,Jauhiainen M,Olkkonen VM,Tenhunen J,Ehnholm C

更新日期：2003-09-01 00:00:00

abstract：:Inositol lipid kinases have been studied extensively in both plant and animal systems. However, major limitations for in vitro studies of recombinant lipid kinases are the low specific activity and instability of the purified proteins. Our goal was to determine if cyclodextrins would provide an effective substrate del...

journal_title：Journal of lipid research

authors： Davis AJ,Perera IY,Boss WF

更新日期：2004-09-01 00:00:00

abstract：:Serine palmitoyltransferase [EC 2.3.1.50] initiates the biosynthesis of sphingolipids by catalyzing the condensation of a fatty acyl-CoA with serine to yield the committed intermediate 3-ketosphinganine or one of its homologues. The presence of serine palmitoyltransferase in aorta was established under optimal assay c...

journal_title：Journal of lipid research

authors： Williams RD,Sgoutas DS,Zaatari GS

更新日期：1986-07-01 00:00:00

abstract：:Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyt...

journal_title：Journal of lipid research

authors： Meital LT,Windsor MT,Ramirez Jewell RML,Young P,Schulze K,Magee R,O'Donnell J,Jha P,Perissiou M,Golledge J,Bailey TG,Brooks P,Askew CD,Russell FD

更新日期：2019-06-01 00:00:00

abstract：:Lysosomal acid lipase (LAL) is essential for the hydrolysis of triglycerides (TG) and cholesteryl esters (CE) in lysosomes. A mouse model created by gene targeting produces no LAL mRNA, protein, or enzyme activity. The lal-/- mice appear normal at birth, survive into adulthood, and are fertile. Massive storage of TG a...

journal_title：Journal of lipid research

authors： Du H,Heur M,Duanmu M,Grabowski GA,Hui DY,Witte DP,Mishra J

更新日期：2001-04-01 00:00:00

abstract：:The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which accelerated cholesterol catabolism in mice. When this species of bac...

journal_title：Journal of lipid research

authors： Kellogg TF,Knight PL,Wostmann BS

更新日期：1970-07-01 00:00:00

abstract：:A multiplexed assay was developed by MS to analyze, in a single run, six major human Apos involved in lipoprotein metabolism: ApoA-I, ApoA-II, ApoB100, ApoC-II, ApoC-III, and ApoE. This method was validated in vivo in six subjects who received a 14 h constant infusion of [5,5,5-(2)H3]L-leucine at 10 μM/kg/h. Plasma li...

journal_title：Journal of lipid research

authors： Croyal M,Fall F,Ferchaud-Roucher V,Chétiveaux M,Zaïr Y,Ouguerram K,Krempf M,Nobécourt E

更新日期：2016-03-01 00:00:00

abstract：:It was postulated that specialized microdomains of the plasma membrane, consistent with caveolae, might play a role in cholesterol trafficking in intestinal cells. The existence, therefore, of caveolin and the role of detergent-resistant microdomains of the plasma membrane in cholesterol trafficking were investigated ...

journal_title：Journal of lipid research

authors： Field FJ,Born E,Murthy S,Mathur SN

更新日期：1998-10-01 00:00:00

abstract：:Several studies in humans and animals suggest that LDL particle core enrichment in cholesteryl oleate (CO) is associated with increased atherosclerosis. Diet enrichment with MUFAs enhances LDL CO content. Steroyl O-acyltransferase 2 (SOAT2) is the enzyme that catalyzes the synthesis of much of the CO found in LDL, and...

journal_title：Journal of lipid research

authors： Melchior JT,Sawyer JK,Kelley KL,Shah R,Wilson MD,Hantgan RR,Rudel LL

更新日期：2013-09-01 00:00:00

abstract：:The role of phosphodiesterase in glucagon resistance of large adipocytes was investigated. A comparison was made of phosphodiesterase activities of homogenates prepared from isolated small (mean diameter approximately 45 micro m) and large (mean diameter approximately 78 micro m) adipocytes, using various concentratio...

journal_title：Journal of lipid research

authors： De Santis RA,Gorenstein T,Livingston JN,Lockwood DH

更新日期：1974-01-01 00:00:00

abstract：:Eubacterium sp. 144 dehydroxylated 16 alpha-hydroxy-progesterone; however, the expected intermediate, delta 16-progesterone, did not accumulate to significant concentrations in the culture medium. Moreover, the final end product of this biotransformation, 17 alpha-progesterone, was produced at a very slow rate. It was...

journal_title：Journal of lipid research

authors： Glass TL,Winter J,Bokkenheuser VD,Hylemon PB

更新日期：1982-02-01 00:00:00

abstract：:The concentration dependence of the 500 MHz 1H-NMR spectra of taurocholate, taurochenodeoxycholate, taurodeoxycholate, and the monosulfate esters of taurochenodeoxycholate has been examined at 0.154 M NaCl in D2O. The resonances of the C18, C19, and C21 methyl groups and the C23 methylene group are differentially broa...

journal_title：Journal of lipid research

authors： Stevens RD,Ribeiro AA,Lack L,Killenberg PG

更新日期：1992-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission can be partly attributed to the drug resistance advantage of AML blast...

journal_title：Journal of lipid research

authors： Tan SF,Dunton W,Liu X,Fox TE,Morad SAF,Desai D,Doi K,Conaway MR,Amin S,Claxton DF,Wang HG,Kester M,Cabot MC,Feith DJ,Loughran TP Jr

更新日期：2019-06-01 00:00:00

abstract：:Seven Z-octadecenoic acids having the double bond located in positions 6Z to 13Z were photooxidized. The resulting hydroperoxy-E-octadecenoic acids [HpOME(E)] were resolved by chiral phase-HPLC-MS, and the absolute configurations of the enantiomers were determined by gas chromatographic analysis of diastereoisomeric d...

journal_title：Journal of lipid research

authors： Oliw EH,Wennman A,Hoffmann I,Garscha U,Hamberg M,Jernerén F

更新日期：2011-11-01 00:00:00

abstract：:Lipids secreted form the bovine meibomian glands were assigned to following classes: cholesteryl esters (A) (fatty acyl chain lengths from 15 to 27 carbon atoms), 41%; wax esters, 29%; triacylglycerols, 10%; and cholesteryl ester (B) (fatty acyl chain lengths from 14 to 18 carbons), 15%. The remaining 5% consisted of ...

journal_title：Journal of lipid research

authors： Baron C,Blough HA

更新日期：1976-07-01 00:00:00

abstract：:Acyl-coenzyme A:diacylglycerol transferase (DGAT), fatty acid synthetase (FAS), and LPL are three enzymes important in adipose tissue triglyceride accumulation. To study the relationship of DGAT1, FAS, and LPL with insulin, we examined adipose mRNA expression of these genes in subjects with a wide range of insulin sen...

journal_title：Journal of lipid research

authors： Ranganathan G,Unal R,Pokrovskaya I,Yao-Borengasser A,Phanavanh B,Lecka-Czernik B,Rasouli N,Kern PA

更新日期：2006-11-01 00:00:00

abstract：:Lec9 Chinese hamster ovary cells were found previously to be defective in the synthesis of N-linked glycans. This appeared to be the result of a defect in the synthesis of oligosaccharide lipid and lipid phosphate (Rosenwald, Stanley, and Krag. 1989. Mol. Cell. Biol. 9: 914-924). In this study we analyzed the steady s...

journal_title：Journal of lipid research

authors： Rosenwald AG,Krag SS

更新日期：1990-03-01 00:00:00

abstract：:The accumulation of phosphatidylcholine hydroperoxide (PCOOH), a primary oxidation product of phosphatidylcholine (PC), in blood plasma and tissues has been observed in various pathological conditions, including atherosclerosis. However, the biological roles of PCOOH in these conditions remain unknown. To estimate the...

journal_title：Journal of lipid research

authors： Asai A,Okajima F,Nakagawa K,Ibusuki D,Tanimura K,Nakajima Y,Nagao M,Sudo M,Harada T,Miyazawa T,Oikawa S

更新日期：2009-05-01 00:00:00

abstract：:Palmitoleic acid is a minor monounsaturated fatty acid in the human diet and in blood plasma. Because macadamia oil is at least one potentially large source of palmitoleic acid, we tested its effect on plasma lipid levels against two other dietary fatty acids, oleic acid and palmitic acid. The dietary adjustments, thr...

journal_title：Journal of lipid research

authors： Nestel P,Clifton P,Noakes M

更新日期：1994-04-01 00:00:00

abstract：:To assess the possible role of altered hepatic processing of free fatty acids in dietary sucrose-induced accumulation of triglyceride in the liver and blood plasma, livers from rats fed commercial laboratory stock and high sucrose diets were perfused both with and without oleic acid substrate. Consumption of the sucro...

journal_title：Journal of lipid research

authors： Yamamoto M,Yamamoto I,Tanaka Y,Ontko JA

更新日期：1987-10-01 00:00:00

abstract：:Lipoproteins internalized by the LDL receptor (LDLR) are released from this receptor in endosomes through a process that involves acid-dependent conformational changes in the receptor ectodomain. How acidic pH promotes this release process is not well understood. Here, we assessed roles for six histidine residues for ...

journal_title：Journal of lipid research

authors： Dong H,Zhao Z,LeBrun DG,Michaely P

更新日期：2017-02-01 00:00:00

abstract：:Treatment of native human Lp(a) under nondenaturing conditions with dithiothreitol yielded both a lipoprotein particle and a lipid-free protein component that could be separated by either ultracentrifugation at d 1.063 g/ml or heparin-Sepharose chromatography. The protein component only showed antigenicity against ant...

journal_title：Journal of lipid research

authors： Armstrong VW,Walli AK,Seidel D

更新日期：1985-11-01 00:00:00

abstract：:Significant amounts of ursodeoxycholic acid (UDCA) used for the treatment of patients with primary biliary cirrhosis (PBC) become epimerized at C-3 to isoUDCA. We investigated the metabolism of isoUDCA and a possible pharmacologic effect in five patients (51.4 +/- 5.8 years old; 3 females, 2 males) with PBC and persis...

journal_title：Journal of lipid research

authors： Marschall HU,Broomé U,Einarsson C,Alvelius G,Thomas HG,Matern S

更新日期：2001-05-01 00:00:00

abstract：:We have developed a procedure to quantify apolipoprotein (apo) B-100, apoB-48, and apoE in human triglyceride-rich lipoproteins. This procedure permits delipidation of small amounts of triglyceride-rich lipoproteins without appreciable losses, and quantification of these apolipoproteins in samples containing as little...

journal_title：Journal of lipid research

authors： Kotite L,Bergeron N,Havel RJ

更新日期：1995-04-01 00:00:00