Abstract:
:A homology model of the Arabidopsis thaliana UV resistance locus 8 (UVR8) protein is presented herein, showing a seven-bladed β-propeller conformation similar to the globular structure of RCC1. The UVR8 amino acid sequence contains a very high amount of conserved tryptophans, and the homology model shows that seven of these tryptophans cluster at the 'top surface' of the UVR8 protein where they are intermixed with positive residues (mainly arginines) and a couple of tyrosines. Quantum chemical calculations of excitation spectra of both a large cluster model involving all twelve above-mentioned residues and smaller fragments thereof reveal that absorption maxima appearing in the 280-300 nm range for the full cluster result from interactions between the central tryptophans and surrounding arginines. This observation coincides with the published experimentally measured action spectrum for the UVR8-dependent UV-B stimulation of HY5 transcription in mature A. thaliana leaf tissue. In total these findings suggest that UVR8 has in fact in itself the ability to be an ultraviolet-B photoreceptor in plants.
journal_name
J Chem Inf Modeljournal_title
Journal of chemical information and modelingauthors
Wu M,Grahn E,Eriksson LA,Strid Adoi
10.1021/ci200017fsubject
Has Abstractpub_date
2011-06-27 00:00:00pages
1287-95issue
6eissn
1549-9596issn
1549-960Xjournal_volume
51pub_type
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