Abstract:
:Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile. Rare cases of overdose-related adverse effects have been reported in the literature. Described herein are the circumstances and autopsy findings of a 62-year-old woman with a history of depression, whose death was caused by intentional ingestion of excess gabapentin. The postmortem peripheral blood gabapentin concentration as determined by high-performance liquid chromatography/tandem mass spectroscopy was 88 μg/mL. Previously reported cases of individuals surviving gabapentin overdoses are discussed and compared with this case. Based on a review of the available literature, this appears to be the first published report of a death due solely to gabapentin toxicity.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Middleton Odoi
10.1111/j.1556-4029.2011.01798.xsubject
Has Abstractpub_date
2011-09-01 00:00:00pages
1373-5issue
5eissn
0022-1198issn
1556-4029journal_volume
56pub_type
杂志文章abstract::Thromboemboli were found diffusely throughout the pulmonary vasculature system of a 76-year-old white female who died unexpectedly 3 days following injury and repair of a left hip intracapsular fracture. A diffuse chronic nonspecific myocarditis with marked fat atrophy, an acute myocardial infarct of the posterior lef...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::Intercostal and age differences in the sternal rib end morphology of documented female skeletons from Spitalfields and St. Bride's are examined. The morphology was captured using three-dimensional morphometrics and the statistical analyses employed included parametric and nonparametric MANOVA, discriminant analysis, a...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.12047
更新日期:2013-03-01 00:00:00
abstract::Forensic psychiatrists should be aware of the many ways that paranoid individuals may present within the legal system. Litigious paranoids often utilize the legal system as a vehicle to act out their fantasies and delusional preoccupations. Imaginary grievances, accusations based on delusional ideation, and irrational...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::The U.S. agricultural sector is vulnerable to intentionally introduced microbial threats because of its wide and open distribution and economic importance. To investigate such events, forensically valid assays for plant pathogen detection are needed. In this work, real-time PCR assays were developed for three model pl...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.12321
更新日期:2014-03-01 00:00:00
abstract::Most studies of saw marks have focused on morphological characteristics and their utility in identifying saws suspected to have been utilized in cases of criminal dismemberment. The present study examined the extent to which metric analysis may be used to correlate saw blade measurements with minimum kerf widths (MKWs...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.14556
更新日期:2021-01-01 00:00:00
abstract::When determining an age estimate from adult skeletal remains, forensic anthropologists face a series of methodological choices. These decisions, such as which skeletal region to evaluate, which methods to apply, what statistical information to use, and how to combine information from multiple methods, ultimately impac...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/j.1556-4029.2011.01979.x
更新日期:2012-03-01 00:00:00
abstract::The recent decline in the incidence of the SIDS in the District of Columbia has permitted identification of what appears to be two separate groups of cases within the generic SIDS population. While deaths of bed-sharing victims remained relatively constant throughout the study period, a greater than fourfold decrease ...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract::Internal standards are commonly used for the quantitative determination of drugs of abuse and their metabolites (drug/metabolite) in biological fluids and tissues by the selective ion monitoring (SIM) gas chromatography/mass spectrometry (GC/MS) procedure. Analogs of drugs/metabolites that are labeled with three or mo...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::Although there is considerable literature on grief and grief work, there have been few studies of the grief process in those who have killed someone. This paper reviews the scope of this problem in England and Wales and examines a number of issues in connection with the grieving process in those who have killed but, b...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract::This is a report on a descriptive study made of defendants charged with at least one count of sexual assault who were examined at the Forensic Psychiatry Clinic of the Supreme Court of the State of New York for the Borough of Manhattan during the calendar year 1974. ...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::In this article, the authors discuss the problem of forensic authentication of digital audio recordings. Although forensic audio has been addressed in several articles, the existing approaches are focused on analog magnetic recordings, which are less prevalent because of the large amount of digital recorders available...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/j.1556-4029.2010.01395.x
更新日期:2010-07-01 00:00:00
abstract::This report describes the genetic identification of James "Earthquake McGoon" McGovern, a WWII fighter ace who perished in Laos while providing supplies to French troops during the French Indochina war. Because reference samples were unavailable for all of the potential casualties, testing of the entire mitochondrial ...
journal_title:Journal of forensic sciences
pub_type: 历史文章,杂志文章
doi:10.1111/j.1556-4029.2007.00506.x
更新日期:2007-09-01 00:00:00
abstract::The purpose of this paper is to discuss some of the major factors that can affect age-at-death predictions when using histomorphological methods. Although evidence suggests that some of the currently available methods are more reliable and accurate, and there are a number of factors other than chronological age that c...
journal_title:Journal of forensic sciences
pub_type: 杂志文章,评审
doi:
更新日期:1988-01-01 00:00:00
abstract:POPULATION:The distribution of allele frequencies have been analyzed at two short tandem repeat (STR) loci FES and D2S1328 among five anthropologically distinct ethnic groups of India namely Ezhavas, Nairs, Arayas, Vishwakarma and Muslims. Muslims are religio-ethnic group while other populations mentioned above belong ...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::The importance of forensic age estimation in living subjects has grown over the last few years. In dental age estimation, tooth eruption is a parameter of developmental morphology that can be analyzed by either clinical examination or by evaluation of dental X-rays. In the present study, we determined the stage of wis...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/j.1556-4029.2007.00534.x
更新日期:2007-09-01 00:00:00
abstract::The foot measurements are important in forensic field as they can be used as body height predictors for an individual. The morphology of human feet shows the variations and therefore the aim of this study was to find the relation between stature and foot measurements and to generate population-specific equations. We m...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.12059
更新日期:2013-03-01 00:00:00
abstract::This report details the medical investigation of the crash of Galaxy Flight 203, on 21 Jan. 1985, near Reno, Nevada. Sixty-eight persons died at the scene, two died during hospitalization, and one victim survived. After completion of autopsies on all victims, pathologists determined causes of death based upon injuries...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1987-09-01 00:00:00
abstract::Between December 2007 and January 2008, people suffered from food poisoning in the Japanese prefectures of Chiba and Hyogo after eating frozen dumplings (gyoza) produced in China, which had very high concentrations (1490-19,290 ppm) of methamidophos (O,S-dimethyl phosphoramidothioate). Thus, we measured the stable car...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.12825
更新日期:2015-09-01 00:00:00
abstract::Jet-propelled personal watercraft (PWC) or jet-skis have become increasingly popular. The means of propulsion of PWC, which is a jet of water forced out of small nozzle at the rear of the craft, combined with a high risk of falling off of the seat and into close proximity with the water jet stream, raise the potential...
journal_title:Journal of forensic sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1556-4029.2012.02250.x
更新日期:2013-01-01 00:00:00
abstract::A simple method using purge-and-trap gas chromatography/mass spectrometry (P&T-GC/MS) for forensic examination of oil stains was studied. Carboxylic acids, chosen as target components for discrimination of oil samples, were extracted from stains with ether, methyl esterified by tetramethylammonium hydroxide, and analy...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::In recent years, a number of studies have demonstrated that forensic examiners can be biased by task-irrelevant contextual information. However, concerns relating to methodological flaws and ecological validity attenuate how much the current body of knowledge can be applied to real-life operational settings. The curre...
journal_title:Journal of forensic sciences
pub_type: 杂志文章,评审
doi:10.1111/1556-4029.14220
更新日期:2020-03-01 00:00:00
abstract::The United States Supreme Court, in the recent case of Riggins v. Nevada, extended its examination of the issue of involuntary treatment with anti-psychotic medication to the mentally disabled facing criminal trial. Although this was an extreme case where the defendant faced a possible death sentence, the involuntary ...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::"Suicide notes" are the notes, where the victim has documented the intention to terminate one's own life. The victim generally writes them on a paper, notebook, wall, or mirror by means of pen or marker. However, suicide notes written on one's own body are very rare, and suicide note engraved by some metallic objects ...
journal_title:Journal of forensic sciences
pub_type:
doi:10.1111/1556-4029.12927
更新日期:2016-01-01 00:00:00
abstract::Five diesel samples were analyzed by gas chromatography-mass spectrometry (GC-MS) using six GC temperature programs, aiming to investigate the effect of temperature program on association and discrimination of the samples. Temperature programs varied by ramp rate and incorporated one- or two-step temperature ramps. Pe...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/j.1556-4029.2009.01234.x
更新日期:2010-01-01 00:00:00
abstract::Previous attempts to sex juvenile skeletons have focused on the application of qualitative or semi-quantitative techniques. This study applies a variety of geometric morphometric methods, including eigenshape analysis, to this problem. Six metric criteria for the ilia were tested with the aim of investigating previous...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/j.1556-4029.2008.00656.x
更新日期:2008-03-01 00:00:00
abstract::Owing to the scanty evidence on usefulness of information of appearance of gray hair for age estimation, this study was conducted to estimate age based on the appearance of gray hair on different body sites in a sample of autopsy cases in Sri Lanka. A descriptive cross-sectional study was conducted in Teaching Hospita...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.13375
更新日期:2017-07-01 00:00:00
abstract::Adermatoglyphia is a very rare autosomal-dominant condition that is genetically inherited and causes an individual to be born without conventional ridge detail on either their palmar or plantar surfaces (the fingers and palms of the hands and the toes and the soles of the feet). While adermatoglyphia has been the focu...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/1556-4029.14597
更新日期:2021-01-01 00:00:00
abstract::The two cases presented here involve deaths that were due to dichloromethane or chloroform poisoning. The dichloromethane and chloroform were determined in biological specimens by headspace gas chromatography with mass spectrometric detector. In one case, dichloromethane concentrations found were 252 mg/L (blood), 75 ...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Separation of male and female soft tissue depths into discrete groups for craniofacial identification implies that males and females differ enough from each other, with respect to this application, for this distinction to be useful. In this study, previously published soft tissue depth data were analyzed for sex separ...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::Fatalities related to sporting events are predominantly caused by blunt force injuries especially due to the emotional involvement of crowd, but occasionally other types of trauma are reported as well. A case of very rare trauma caused by shooting with a hand-held parachute signal rocket during a football match is pre...
journal_title:Journal of forensic sciences
pub_type: 杂志文章
doi:10.1111/j.1556-4029.2008.00791.x
更新日期:2008-09-01 00:00:00