Abstract:
:The Drosophila ras2 and rop gene pair are governed by a common promoter. Characterisation of the Drosophila ras2/rop bidirectional promoter has revealed that a single major protein complex (M), composed of two subunits (factors A and B) interacts with two central promoter domains (regions A and B). To define the transcriptional control elements contained within region A (-58 to -39) we performed mutational analysis on several putative elements. This approach has revealed that the conserved TATA-like, SRE-like and GATA-like sequences do not interact with factor A and are not regulatory elements of this promoter. Nucleotides -56 to -49 bear perfect homology to the Drosophila DNA replication-related element (DRE, TATCGATA) found in two genes involved in DNA replication and cell proliferation, the Drosophila proliferating cell nuclear antigen (PCNA) and DNA polymerase a. A CG pair (-53 and -52) has been pinpointed as cardinal for factor A binding. Factor A has been partially purified and identified as a 20 kDa polypeptide by photo-chemical crosslinking analysis.
journal_name
Int J Oncoljournal_title
International journal of oncologyauthors
Lightfoot K,Tai A,Segev Odoi
10.3892/ijo.7.5.1185subject
Has Abstractpub_date
1995-11-01 00:00:00pages
1185-91issue
5eissn
1019-6439issn
1791-2423journal_volume
7pub_type
杂志文章abstract::Although the hematopoietic reconstituting ability of human umbilical cord blood cells (UCBC) is well documented, their antitumor cytotoxic potential has not been well studied. Therefore, UCBC were compared to normal peripheral blood stem cells (PBSC) and bone marrow (BM) stem cell harvests for cytomorphology, antitumo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.4.791
更新日期:1998-10-01 00:00:00
abstract::Although strong evidence is available suggesting that microenvironmental parameters play a role in lymphogenic or hematogenic metastasis, the underlying mechanisms are still unclear and further investigations of this topic are needed. For such a study however, an appropriate model of metastasis for in vivo analysis of...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::The p16INK4 gene, encoding a cyclin-dependent kinase inhibitor, is frequently methylated in colorectal cancer, and a side-specific methylation frequency was suggested. To clarify the frequency of real loss of tumor suppressor function dependent on anatomical localization, we investigated 43 primary colorectal carcinom...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::Angiogenesis is a prerequisite for the growth and metastasis of solid tumors. Studies have confirmed that in the absence of angiogenesis, tumors rarely have the ability to develop beyond a few millimeters in diameter. Tumor-associated endothelium is activated by the production of soluble factors by tumor and stromal c...
journal_title:International journal of oncology
pub_type: 杂志文章,评审
doi:
更新日期:2004-08-01 00:00:00
abstract::Photodynamic therapy (PDT) is a tool against neoplastic and non-neoplastic diseases. PDT is capable to induce different cell death mechanisms in vitro, triggered in a dose-dependent manner. Relationships between PDT and apoptosis or necrosis induction are well-known, but other cell death mechanisms triggered after PDT...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo_32_6_1189
更新日期:2008-06-01 00:00:00
abstract::Lack of life-prolonging therapies has provided much of the impetus for seeking complementary and alternative management/treatment options by prostate cancer (CaP) patients. Among these, the use of dietary supplements and botanical products has been showing a sustained increase in recent years, owing in part to some en...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract::Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non‑coding RNAs (lncRNAs) play a critical role in CRC progression and metastasis; however, the bio...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2018.4451
更新日期:2018-09-01 00:00:00
abstract::Currently, it is not entirely clear whether hypoxia-inducible factor-1α (HIF-1α) is involved in the regulation of COX-2 expression and epithelial-to-mesenchymal transition (EMT), and whether these events affect the prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolizati...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2016.3421
更新日期:2016-05-01 00:00:00
abstract::TP53 gene, encoding tumor protein P53, is frequently inactivated in various types of human cancer, including colorectal, lung, and gastric cancer. Cancer cells with TP53 mutation acquire malignant potentials, such as selective growth advantage, genomic instability, resistance to apoptosis, and promotion of angiogenesi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
abstract::The Her-2 receptor coded for by the proto-oncogenic erbB-2 gene is a clinically validated target for treatment of a significant genetic subclass of breast cancers, and Her-2 is also overexpressed or mutated in a range of other cancers. In an approach to exploit antisense mediated splicing interference as a means of ma...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::Cordycepin (3'-deoxyadenosine), a major bioactive compound of Cordyceps militaris, has many pharmacological actions, such as anti-inflammatory and anticancer activities. In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in L...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1332
更新日期:2012-05-01 00:00:00
abstract::A promising family of anticancer agents, the camptothecins, is noted for their ability to induce apoptosis specifically in malignant cells. However, a major obstacle for successful cancer treatment by these and other chemotherapeutic agents is the intrinsic or acquired resistance to drug treatment. Resistance to 9NC6,...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Allyl isothiocyanate (AITC), a member of the isothiocyanate (ITC) family found in a constituent of cruciferous vegetables, possesses anticancer activity and induces apoptosis in various types of human cancer cell lines. However, no available information showed antitumor effects in human breast adenocarcinoma cells. Th...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2012.1640
更新日期:2012-12-01 00:00:00
abstract::Prognosis of patients with undifferentiated gastric cancer is generally poor. The expression of various microRNAs (miRNAs) has not been comprehensively investigated in undifferentiated gastric cancer. Total RNA was extracted from the specimens of 42 undifferentiated gastric cancer tissues and paired normal gastric tis...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract::The poor prognosis of Ewing's sarcoma (EWS), together with its high lethal recurrence rate and the side‑effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side‑effects. The oncogenic chimeric protein EWS/FLI1 is the key malignancy driver in mo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.2016
更新日期:2013-09-01 00:00:00
abstract::The inhibitory effects of macrolide antibiotics including clarithromycin (CAM) on autophagy flux have been reported. Although a macrolide antibiotic exhibits no cytotoxicity, its combination with bortezomib (BZ), a proteasome inhibitor, for the simultaneous blocking of the ubiquitin (Ub)‑proteasome and autophagy‑lysos...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2773
更新日期:2015-02-01 00:00:00
abstract::Using two malignant rat glioma cell lines, we tested to what extent peripheral immunization could affect tumor growth in the brain of syngeneic rats. Peripheral subcutaneous (s.c.) immunization was performed with autologous Newcastle-disease-virus (NDV)-infected or non-infected live tumor cells. Thus immunized rats or...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.6.4.759
更新日期:1995-04-01 00:00:00
abstract::The objective of the present study was to establish the individual and combined chemopreventive potential of a widely used non-steroidal anti-inflammatory drug, ibuprofen (IBU), encapsulated in solid lipid nanoparticles (SLNs) for the chemoprevention of pancreatic cancer. The IBU SLNs were optimized using various lipi...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2015.2879
更新日期:2015-04-01 00:00:00
abstract::The enzyme poly(ADP-ribose)polymerase (PARP) has been implicated in several cellular processes by the demonstration of ADP-ribosylation of proteins which play a role in cellular repair of DNA damage, response to ionizing radiation and apoptosis. In addition, ADP-ribosylation has been shown to play a role in cell cycle...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.8.4.803
更新日期:1996-04-01 00:00:00
abstract::In a recent study, we evaluated the efficacy and toxicity of 5-fluorouracil (5-FU), cisplatin (CDDP), and 5-FU plus CDDP (FP treatment) in gastric cancer cell lines and examined the relationship between the response to FP treatment and apoptosis. Our study indicated that there may be prognostic value in measuring p53 ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-06-01 00:00:00
abstract::Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS) and binds to a variety of receptors, which recently have also been detected in peripheral, non-excitable cells. New research suggests that this abundant amino acid might also be involved in the growth of tumor cells acting via novel...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2005-09-01 00:00:00
abstract::Subsequently to the publication of the above paper, the authors have realized that Figs. 3 and 4 contained errors. Two sets of bands in Figs. 3D and 4B were erroneously placed during the process of figure preparation. In Fig. 3D, the β‑actin bands for the PANC‑1 and CFPAC‑1 cells were presented incorrectly, whereas in...
journal_title:International journal of oncology
pub_type: 杂志文章,已发布勘误
doi:10.3892/ijo.2019.4871
更新日期:2019-11-01 00:00:00
abstract::A putative tumor suppressor, PTEN/MMAC1 gene was recently identified at 10q23 and was found to be frequently altered in several types of human tumors. To determine the possible role of this gene in human ovarian tumors, we screened 31 unselected primary epithelial ovarian cancers with matched normal tissues and 7 ovar...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.1.101
更新日期:1998-07-01 00:00:00
abstract::Esculetin (6,7-dihydroxycoumarin), a coumarin compound, is known to inhibit proliferation and induce apoptosis in several types of human cancer cells and is regarded as a promising chemotherapeutic agent. The purpose of the present study was to investigate the anti-proliferative effects of esculetin on two oral squamo...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2014.2700
更新日期:2015-01-01 00:00:00
abstract::Progression of oral carcinomas associates with aberrant activation and inactivation of molecules that work in established or unknown pathways. Although mucosa‑associated lymphoid tissue 1 (MALT1) expressed in normal oral epithelium is inactivated in the aggressive subset of carcinomas with worse prognosis, phenotypic ...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1990
更新日期:2013-09-01 00:00:00
abstract::The signal transducer and activator of transcription 3 (STAT3) factor plays an important role in the tumorigenicity of cancer stem cells. The purpose of this study was to investigate the inhibitory mechanism of this pathway acting through the tumor suppressor von Hippel-Lindau (VHL) protein in glioma cancer stem cells...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2013.1773
更新日期:2013-03-01 00:00:00
abstract::The purpose of this study was to determine, using fluorescence in situ hybridization (FISH), whether treatment of cancer cells with 3'-azido-2'-3'-dideoxythymidine (AZT) has any effect on telomere length as determined by the telomeric signal intensity. To do so, we treated a metastatic murine melanoma cell line (K-173...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.13.5.923
更新日期:1998-11-01 00:00:00
abstract::Simultaneous resistance of cancer cells to multiple cytotoxic drugs, multidrug resistance (MDR), is the major limitation to the successful chemotherapeutic treatment of disseminated neoplasms. The 'classical' MDR phenotype is conferred by MDR1/P-glycoprotein (MDR1/P-gp) that is expressed in almost 50% of human cancers...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::We have examined antitumor effect of murine neuroblastoma cells (C1300) retrovirally transduced with interleukin-4 (IL-4) gene in syngeneic A/J and nude mice. Although in vitro proliferation of IL-4-secreting C1300 cells (C1300/IL-4) was not different from that of wild-type cells, the in vivo tumor growth of C1300/IL-...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.12.5.1067
更新日期:1998-05-01 00:00:00
abstract::Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine...
journal_title:International journal of oncology
pub_type: 杂志文章
doi:10.3892/ijo.2017.4144
更新日期:2017-11-01 00:00:00