Antimicrobial treatment of anaerobic infections.

abstract：:Therapy of hepatitis C virus (HCV) infection may prevent progression to cirrhosis, hepatocellular carcinoma and end-stage liver disease. The cornerstone of treatment has long been standard IFN-alpha, the use of which was associated with a sustained biochemical and viral response in only a small proportion of patients....

journal_title：Expert opinion on pharmacotherapy

authors： Toniutto P,Fabris C,Pirisi M

更新日期：2006-10-01 00:00:00

abstract：:Despite the revolutionary introduction of antibiotic therapy in the post-World War II era, primary care physicians continue to struggle with the issue of optimal treatment strategies for bacterial infection and the growing problem of antimicrobial resistance. The aggressive use of potent agents as first-line therapy m...

journal_title：Expert opinion on pharmacotherapy

authors： Nicolau DP

更新日期：2004-02-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension may occur in the context of incomplete lysis of acute pulmonary emboli, resulting in the obstruction of pulmonary blood flow, as well as progressive right ventricular dysfunction and failure. The treatment of choice for this condition is surgical removal of the obstructing...

journal_title：Expert opinion on pharmacotherapy

authors： Hughes R,Jais X,Suntharalingam J,Humbert M,Parent F,Simonneau G,Pepke-Zaba J

更新日期：2006-06-01 00:00:00

abstract：:Colorectal cancer is one of the most common types of cancer in both men and women. Multiple chemotherapy combinations exist; however, there is currently no strategy for individualised therapy selection prior to treatment. Genetic polymorphisms in genes involved in the metabolism, transport or targets for the commonly ...

journal_title：Expert opinion on pharmacotherapy

authors： Marsh S

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Irritable bowel syndrome (IBS) treatment is challenging physicians because of its multifactorial physiopathology. In particular, abdominal pain and diarrhea management lack one unique effective pharmacological remedy. Opioid receptors, present in the central nervous system (CNS) and the enteric nervous sys...

journal_title：Expert opinion on pharmacotherapy

authors： Scarpellini E,Laterza L,Ianiro G,Tack J,Abenavoli L,Gasbarrini A

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Treating acute myeloid leukemia (AML) in older adults remains daunting. The unique biology often renders conventional chemotherapies less effective. Accurately predicting the toxicities of treatment is another unresolved challenge. Treatment planning thus requires a good knowledge of the current trial data...

journal_title：Expert opinion on pharmacotherapy

authors： Michaelis LC,Klepin HD,Walter RB

更新日期：2018-06-01 00:00:00

abstract：:The recently published Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) assessed the efficacy and safety of abaloparatide (80 µg daily subcutaneous) (ABL) vs placebo during 18 months, in postmenopausal osteoporosis. Teriparatide (20 µg daily subcutaneous) (TPD) was used as an open label active comparator...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY,Al Daghri NM,Bruyere O

更新日期：2017-12-01 00:00:00

abstract：:Fluticasone propionate (FP) is a potent inhaled corticosteroid (ICS) for the treatment of asthma. It is currently marketed in both the United States (as Flovent) and Europe (as Flixotide). Fluticasone is available in both aerosolised metered dose inhaler (MDI) and dry powder devices, with dosages ranging from 44-500 m...

journal_title：Expert opinion on pharmacotherapy

authors： Staresinic AG,Sorkness CA

更新日期：2000-09-01 00:00:00

abstract：AIM:To evaluate the efficacy and adverse effects of IDegLira and IGlarLixi treatment and to perform a comparison between two strategies. METHODS:The registration number is CRD42017053952. Randomized controlled trials of IGlarLixi treatment or IDegLira treatment compared with placebo or active hypoglycemic agents in ty...

journal_title：Expert opinion on pharmacotherapy

authors： Cai X,Gao X,Yang W,Ji L

更新日期：2017-12-01 00:00:00

abstract：:This is a review of the literature comparing the efficacy and safety of drug-eluting stents (DES) versus bare-metal stents (BMS) in patients with acute myocardial infarction (MI). The present article reviews whether DES are beneficial in the setting of primary percutaneous coronary intervention (PCI), and this has bee...

journal_title：Expert opinion on pharmacotherapy

authors： Yeter E,Kurt M,Silay Y,Anderson HV,Denktas AE

更新日期：2009-01-01 00:00:00

abstract：:The American Heart Association annual meeting must be one of the largest scientific gatherings, attracting over 30,000 delegates. The meeting at the end of last year was held in Atlanta, USA, the 2000 meeting will be in New Orleans, USA. The following highlights represent my own interests. ...

journal_title：Expert opinion on pharmacotherapy

authors： Lunnon MW

更新日期：2000-03-01 00:00:00

abstract：INTRODUCTION:Stiripentol and vigabatrin are the two anticonvulsant drugs currently approved in severe infantile-onset epilepsies, respectively Dravet syndrome and infantile spasms. AREAS COVERED:For both, the indication was discovered by chance thanks to an exploratory study. Both demonstrated indisputable efficacy th...

journal_title：Expert opinion on pharmacotherapy

authors： Chiron C

更新日期：2016-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Inhibition of the aromatase enzyme in postmenopausal women reduces levels of estrogens, which is of therapeutic value in hormone-sensitive breast cancer. Exemestane is a third-generation steroidal irreversible inactivator of the aromatase enzyme used in early and advanced breast cancer for the t...

journal_title：Expert opinion on pharmacotherapy

authors： Bertelli G,Gangadhara S

更新日期：2010-08-01 00:00:00

abstract：:At least two factors relating to pain management using oral analgesics suggest that combination strategies merit consideration: many pains arise from more than one physiological cause and current analgesics have adverse effect profiles that might be reduced by combination with another agent in smaller doses or with le...

journal_title：Expert opinion on pharmacotherapy

authors： Raffa RB,Clark-Vetri R,Tallarida RJ,Wertheimer AI

更新日期：2003-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Rhinosinusitis is a common illness that represents a substantial economic burden. The vast majority of cases resolve spontaneously but a small proportion develops a secondary bacterial infection. Accurate diagnosis of rhinosinusitis depends upon clinical assessment. Isolation of the causative ag...

journal_title：Expert opinion on pharmacotherapy

authors： Brook I

更新日期：2010-04-01 00:00:00

abstract：:Introduction: Current therapies of postoperative nausea and vomiting (PONV) are based on a combination of antiemetics from different pharmacological classes. Dopamine receptor antagonists are one of the cornerstones of such multimodal antiemetic approach, with droperidol being the best studied representative of this g...

journal_title：Expert opinion on pharmacotherapy

authors： Smyla N,Koch T,Eberhart LH,Gehling M

更新日期：2020-04-01 00:00:00

abstract：:Synovitis is a painful and, occasionally, disabling disease. Patients with synovitis, especially new onset synovitis, should be referred to a rheumatologist urgently so that they can be assed and treated as quickly as possible. Clinical assessment and investigations are required to help differentiate between transient...

journal_title：Expert opinion on pharmacotherapy

authors： Sokoll KB,Helliwell P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic met...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Hermanns-Lê T,Delvenne P,Piérard-Franchimont C

更新日期：2012-06-01 00:00:00

abstract：:Ribavirin is a very broad-spectrum virustatic antiviral agent, first synthesised in 1972. It is characterised by low toxicity apart from reversible anaemia, usually mild. Its multiple mechanisms of action mean that viral resistance rarely develops. It can be administered orally, intravenously, or via a nebuliser. It h...

journal_title：Expert opinion on pharmacotherapy

authors： Snell NJ

更新日期：2001-08-01 00:00:00

abstract：INTRODUCTION:Status Epilepticus (SE) is the most common neurological emergency of childhood. It requires prompt administration of appropriately selected anti-seizure medications. Areas covered: Following a distinction between estabilished and emergent drugs, we present pharmacological treatment options and their clinic...

journal_title：Expert opinion on pharmacotherapy

authors： Verrotti A,Ambrosi M,Pavone P,Striano P

更新日期：2017-06-01 00:00:00

abstract：:Introduction: Liposarcomas are a heterogeneous group of soft tissue tumors that arise from adipose tissue and are one of the most common soft tissue sarcomas found in adults. Liposarcomas are subclassified into four subtypes with distinct histologic and biologic features that influence their treatment and management. ...

journal_title：Expert opinion on pharmacotherapy

authors： Suarez-Kelly LP,Baldi GG,Gronchi A

更新日期：2019-08-01 00:00:00

abstract：:There is accumulating evidence that tumour necrosis factor (TNF) plays a major role in the pathogenesis of rheumatoid arthritis (RA). Recent biotechnological advances have allowed for the development of agents that directly target TNF, a pro-inflammatory cytokine. In the last 2 years, the US FDA and the EU's Commissio...

journal_title：Expert opinion on pharmacotherapy

authors： Mikuls TR,Moreland LW

更新日期：2001-01-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Current therapy for Parkinson's disease (PD) is primarily directed at reversing the motor symptoms that are the consequence of dopamine deficiency and includes levodopa, dopamine agonists and monoamine oxidase (MAO) B inhibitors. New drugs offering both dopaminergic and non-dopaminergic actions ...

journal_title：Expert opinion on pharmacotherapy

authors： Schapira AH

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Our knowledge about lower respiratory tract infections (LRTIs) has improved substantially in the last years, but the management of respiratory infections is still a challenge and we are still far from using precision medicine in their treatment. Areas covered: The approaches developed in recent years to im...

journal_title：Expert opinion on pharmacotherapy

authors： Cazzola M,Rogliani P,Aliberti S,Blasi F,Matera MG

更新日期：2017-07-01 00:00:00

abstract：:Eradication of HIV infection is the most challenging research area in the HIV/AIDS field. Treatment of HIV infection with antiretrovirals halts viral replication but fails to eradicate infection because it does not eliminate latent viruses. Eradication has only been achieved in one exceptional case after bone marrow t...

journal_title：Expert opinion on pharmacotherapy

authors： Blanco J

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:The introduction of novel agents has significantly improved multiple myeloma (MM) patient outcome during the last two decades. MM received the most drug approvals for any one malignancy during this time period, both in the United States as well as in Europe. Areas covered: Proteasome inhibitors, immunomodu...

journal_title：Expert opinion on pharmacotherapy

authors： Podar K,Pecherstorfer M

更新日期：2017-08-01 00:00:00

abstract：:Introduction: Investigational anti-VEGF treatments for neovascular age-related macular degeneration (nAMD) aim to improve visual outcomes and reduce treatment burden; these include long-acting agents, combination strategies, topical agents, sustained-release, and genetic therapies. Areas covered: The authors provide a...

journal_title：Expert opinion on pharmacotherapy

authors： Al-Khersan H,Hussain RM,Ciulla TA,Dugel PU

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition traditionally viewed as a severe destructive disease affecting physical health and global wellbeing. The treatment strategies for RA have changed in the last decades from mainly symptomatic towards a more vigorous and targeted approac...

journal_title：Expert opinion on pharmacotherapy

authors： De Cock D,Van der Elst K,Meyfroidt S,Verschueren P,Westhovens R

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Treatment options for hair disorders are generally very limited. These options are even more limited in children due to the lack of trials and clinical research. Moreover, physicians are sometimes scared to treat children with drugs without safety data, especially because most hair disorders are benign. A...

journal_title：Expert opinion on pharmacotherapy

authors： Iorizzo M,Oranje AP

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Allergic rhinitis is a common condition with increasing prevalence and is associated with several comorbid disorders such as bronchial asthma and atopic dermatitis. If allergen avoidance is not possible, allergen-specific immunotherapy is the only causal treatment option. AREAS COVERED:This review focuses...

journal_title：Expert opinion on pharmacotherapy

authors： Klimek L,Sperl A,Becker S,Mösges R,Tomazic PV

更新日期：2019-01-01 00:00:00