The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation.

Abstract:

:The chromosomes of eukaryotes are organized into structurally and functionally discrete domains. This implies the presence of insulator elements that separate adjacent domains, allowing them to maintain different chromatin structures. We show that the Fun30 chromatin remodeler, Fft3, is essential for maintaining a proper chromatin structure at centromeres and subtelomeres. Fft3 is localized to insulator elements and inhibits euchromatin assembly in silent chromatin domains. In its absence, euchromatic histone modifications and histone variants invade centromeres and subtelomeres, causing a mis-regulation of gene expression and severe chromosome segregation defects. Our data strongly suggest that Fft3 controls the identity of chromatin domains by protecting these regions from euchromatin assembly.

journal_name

PLoS Genet

journal_title

PLoS genetics

authors

Strålfors A,Walfridsson J,Bhuiyan H,Ekwall K

doi

10.1371/journal.pgen.1001334

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

e1001334

issue

3

eissn

1553-7390

issn

1553-7404

journal_volume

7

pub_type

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