Abstract:
:ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the generation of specific cell types for use in regenerative medicine and drug screening. In order to harness their potential, the molecular mechanisms regulating ESC pluripotency, proliferation and differentiation (i.e. cell fate) need to be understood so that pluripotency can be maintained during expansion, while differentiation to specific lineages can be induced accurately when required. The present review focuses on the potential roles that PI3K (phosphoinositide 3-kinase) and GSK-3 (glycogen synthase kinase 3)-dependent signalling play in the co-ordination and integration of mouse ESC pluripotency and proliferation and contrast this with our understanding of their functions in human ESCs.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Welham MJ,Kingham E,Sanchez-Ripoll Y,Kumpfmueller B,Storm M,Bone Hdoi
10.1042/BST0390674subject
Has Abstractpub_date
2011-04-01 00:00:00pages
674-8issue
2eissn
0300-5127issn
1470-8752pii
BST0390674journal_volume
39pub_type
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2020-06-30 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0310134
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2016-06-15 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0340489
更新日期:2006-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0320461
更新日期:2004-06-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2007-08-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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更新日期:2017-04-15 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20120300
更新日期:2013-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0300844
更新日期:2002-11-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0390719
更新日期:2011-06-01 00:00:00
abstract::The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (W...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0360629
更新日期:2008-08-01 00:00:00
abstract::The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. This receptor complex allows for integrated signalling in response to growth fact...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/bst0311220
更新日期:2003-12-01 00:00:00
abstract::SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0351397
更新日期:2007-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20180335
更新日期:2019-02-28 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0381093
更新日期:2010-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2010-02-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0351629
更新日期:2007-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0360684
更新日期:2008-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2008-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2019-04-30 00:00:00
abstract::HD (Huntington's disease) is a late onset heritable neurodegenerative disorder that is characterized by neuronal dysfunction and death, particularly in the cerebral cortex and medium spiny neurons of the striatum. This is followed by progressive chorea, dementia and emotional dysfunction, eventually resulting in death...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0371270
更新日期:2009-12-01 00:00:00
abstract::The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned s...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0360367
更新日期:2008-06-01 00:00:00
abstract::VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) assoc...
journal_title:Biochemical Society transactions
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更新日期:2012-02-01 00:00:00
abstract::Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/
更新日期:2002-04-01 00:00:00
abstract::The 26S proteasome is a non-lysosomal protease in the cytosol and nucleus of eukaryotic cells. Its main function is to mediate ubiquitin-dependent proteolysis. The 26S proteasome is a multimeric complex composed by the 20S proteasome CP (core particle) and the 19S RPs (regulatory particles). Although the atomic struct...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00