Quantification of trace levels of the potential cancer biomarkers formaldehyde, acetaldehyde and propanol in breath by SIFT-MS.

abstract：:The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway f...

journal_title：Journal of breath research

authors： Högman M,Thornadtsson A,Liv P,Hua-Huy T,Dinh-Xuan AT,Tufvesson E,Dressel H,Janson C,Koskela K,Oksa P,Sauni R,Uitti J,Moilanen E,Lehtimäki L

更新日期：2017-09-13 00:00:00

abstract：:Despite recent progress in Critical Care Medicine, sepsis is still a major medical problem with a high rate of mortality and morbidity especially in intensive care units. Oxidative stress induced by inflammation associated with sepsis causes degradation of heme protein, increases microsomal free heme content, promotes...

journal_title：Journal of breath research

authors： Morimatsu H,Takahashi T,Matsusaki T,Hayashi M,Matsumi J,Shimizu H,Matsumi M,Morita K

更新日期：2010-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD)/emphysema risk groups are well defined and screening allows for early identification of disease. The capability of exhaled volatile organic compounds (VOCs) to detect emphysema, as found by computed tomography (CT) in current and former heavy smokers participating in a lung...

journal_title：Journal of breath research

authors： Cristescu SM,Gietema HA,Blanchet L,Kruitwagen CL,Munnik P,van Klaveren RJ,Lammers JW,Buydens L,Harren FJ,Zanen P

更新日期：2011-12-01 00:00:00

abstract：:Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current che...

journal_title：Journal of breath research

authors： Rai M,Spratt D,Gomez-Pereira PR,Patel J,Nair SP

更新日期：2016-10-18 00:00:00

abstract：:Volatile organic compounds (VOCs) in exhaled breath originate from current or previous environmental exposures (exogenous compounds) and internal metabolic (anabolic and catabolic) production (endogenous compounds). The origins of certain VOCs in breath presumed to be endogenous have been proposed to be useful as prec...

journal_title：Journal of breath research

authors： Pleil JD,Stiegel MA,Risby TH

更新日期：2013-03-01 00:00:00

abstract：:The current diagnostic challenge with diagnosing hepatic encephalopathy (HE) is identifying those with minimal HE as opposed to the more clinically apparent covert/overt HE. Rifaximin, is an effective therapy but earlier identification and treatment of HE could prevent liver disease progression and hospitalization. Ou...

journal_title：Journal of breath research

authors： Arasaradnam RP,McFarlane M,Ling K,Wurie S,O'Connell N,Nwokolo CU,Bardhan KD,Skinner J,Savage RS,Covington JA

更新日期：2016-02-11 00:00:00

abstract：:Breath gas analysis provides insight into human metabolism of healthy and ill individuals. As an innovative and non-invasive method, it opens up options to improve diagnostics, monitoring and treatment decisions. Mid-infrared laser absorption spectroscopy is utilized to detect CH(4), H(2)O, CO(2), NH(3) and CH(3)OH in...

journal_title：Journal of breath research

authors： Hannemann M,Antufjew A,Borgmann K,Hempel F,Ittermann T,Welzel S,Weltmann KD,Völzke H,Röpcke J

更新日期：2011-06-01 00:00:00

abstract：:Blood ammonia is routinely used in clinical settings to assess systemic ammonia in hepatic encephalopathy and urea cycle disorders. Despite its drawbacks, blood measurement is often used as a comparator in breath studies because it is a standard clinical test. We sought to evaluate sources of measurement error and pot...

journal_title：Journal of breath research

authors： Spacek LA,Mudalel M,Tittel F,Risby TH,Solga SF

更新日期：2015-12-14 00:00:00

abstract：:In the current pilot study we aimed to determine whether breath analysis could be used to help recognise intra-abdominal infection, using acute appendicitis as an exemplar condition. Our study included 53 patients (aged 18-88 years) divided into three groups: appendix group, 26 (13 male) patients suffering from acute ...

journal_title：Journal of breath research

authors： Andrews BT,Das P,Denzer W,Ritchie GA,Peverall R,Hamade AM,Hancock G

更新日期：2020-10-22 00:00:00

abstract：:Exhaled breath is coming to the forefront of non-invasive biomarker discovery efforts. Concentration of exhaled breath volatile organic compounds (VOCs) on thermal desorption (TD) tubes with subsequent analysis by gas chromatography-mass spectrometry (GC-MS) has dominated this field. As discovery experimentation incre...

journal_title：Journal of breath research

authors： Harshman SW,Mani N,Geier BA,Kwak J,Shepard P,Fan M,Sudberry GL,Mayes RS,Ott DK,Martin JA,Grigsby CC

更新日期：2016-10-12 00:00:00

abstract：:Radiation dose is important in radiotherapy. Too little, and the treatment is not effective, too much causes radiation toxicity. A biochemical measurement of the effect of radiotherapy would be useful in personalisation of this treatment. This study evaluated changes in exhaled breath volatile organic compounds (VOC) ...

journal_title：Journal of breath research

authors： Salman D,Eddleston M,Darnley K,Nailon WH,McLaren DB,Hadjithelki A,Ruszkiewicz D,Langejuergen J,Alkhalifa Y,Phillips I,Thomas CLP

更新日期：2020-10-24 00:00:00

abstract：:There have been a number of studies in which metal oxide sensors (MOS) have replaced conventional analytical detectors in gas chromatography systems. However, despite the use of these instruments in a range of applications including breath research the sensor responses (i.e. resistance changes w.r.t. concentration of ...

journal_title：Journal of breath research

authors： Gould O,Wieczorek T,de Lacy Costello B,Persad R,Ratcliffe N

更新日期：2017-12-06 00:00:00

abstract：:Aircraft engine exhaust increases the number concentration of nanoparticles (NP) in the surrounding environment. Health concerns related to NP raise the question of the exposure and health monitoring of airport workers. No biological monitoring study on this profession has been reported to date. The aim was to evaluat...

journal_title：Journal of breath research

authors： Marie-Desvergne C,Dubosson M,Touri L,Zimmermann E,Gaude-Môme M,Leclerc L,Durand C,Klerlein M,Molinari N,Vachier I,Chanez P,Mossuz VC

更新日期：2016-07-13 00:00:00

abstract：:Since the ancient discovery of the 'sweet odor' in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the 'smell' of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advanceme...

journal_title：Journal of breath research

authors： Wang Z,Wang C

更新日期：2013-09-01 00:00:00

abstract：:Breath tests have been used to investigate many physiological functions. Recently, we have developed a breath test system by using a non-invasive technique in conscious rats. In this study, we investigated the effect of atropine sulfate on the gastric emptying and gastrocecal transit time using [1-(13)C]acetic acid an...

journal_title：Journal of breath research

authors： Uchida M,Yoshida K,Shimizu K

更新日期：2009-12-01 00:00:00

abstract：:Due to its high sensitivity, compact size and low cost ion mobility spectrometry (IMS) has the potential to become a point-of-care breath analyzer. Therefore, we developed a prototype of a compact, closed gas loop IMS with gas chromatographic (GC) pre-separation and high resolving power of R  =  90. In this study, we ...

journal_title：Journal of breath research

authors： Allers M,Langejuergen J,Gaida A,Holz O,Schuchardt S,Hohlfeld JM,Zimmermann S

更新日期：2016-04-08 00:00:00

abstract：:This study investigated whether oral malodour with plaque-related periodontal disease was associated with the prevalence of periodontopathic bacteria in saliva and tongue debris. The subjects were 30 patients who visited the Breath Odour Clinic. An oral examination was performed at baseline and two months after period...

journal_title：Journal of breath research

authors： Kurata H,Awano S,Yoshida A,Ansai T,Takehara T

更新日期：2008-03-01 00:00:00

abstract：:Cancer cells prefer hyperglycolysis versus oxidative phosphorylation, even in the presence of oxygen. This phenomenon is used through the FDG-PET scans, and may affect the exhaled volatile signature. This study investigates the volatile signature in lung cancer (LC) before and after an oral glucose tolerance test (OGT...

journal_title：Journal of breath research

authors： Feinberg T,Alkoby-Meshulam L,Herbig J,Cancilla JC,Torrecilla JS,Gai Mor N,Bar J,Ilouze M,Haick H,Peled N

更新日期：2016-06-07 00:00:00

abstract：:In this study, the effects of aerobic exercise on the upper airways and their defense mechanisms were investigated in athletes. The athletes ran in two different environments: the downtown streets of the city of São Paulo (Street), more polluted, and an urban forest (Forest), less polluted. Thirty-eight young healthy ...

journal_title：Journal of breath research

authors： Cavalcante de Sá M,Nakagawa NK,Saldiva de André CD,Carvalho-Oliveira R,de Santana Carvalho T,Nicola ML,de André PA,Nascimento Saldiva PH,Vaisberg M

更新日期：2016-12-21 00:00:00

abstract：:The measurement of the peak exhaled breath temperature (EBT) during multiple tidal breaths offers an easy, non-invasive tool for monitoring airway inflammation. Chronic obstructive pulmonary disease (COPD) is linked to airway inflammation, which is further aggravated by exacerbations of the disease. However, the peak ...

journal_title：Journal of breath research

authors： Lázár Z,Bikov A,Martinovszky F,Gálffy G,Losonczy G,Horváth I

更新日期：2014-09-18 00:00:00

abstract：:Analysis of breath acetone could be useful in the Intensive Care Unit (ICU) setting to monitor evidence of starvation and metabolic stress. The aims of this study were to examine the relationship between acetone concentrations in breath and blood in critical illness, to explore any changes in breath acetone concentrat...

journal_title：Journal of breath research

authors： Sturney SC,Storer MK,Shaw GM,Shaw DE,Epton MJ

更新日期：2013-09-01 00:00:00

abstract：:Volatile organic compounds (VOCs) in exhaled human breath can serve as potential disease-specific and exposure biomarkers and therefore can reveal information about a subject's health and environment. Pyridine, a VOC marker for exposure to tobacco smoke, and isoprene, a liver disease biomarker, were studied using atmo...

journal_title：Journal of breath research

authors： Kapishon V,Koyanagi GK,Blagojevic V,Bohme DK

更新日期：2013-06-01 00:00:00

abstract：:Exhaled breath collection is used to identify and monitor inflammatory or oxidative components in breath. Exhaled breath sample collection is noninvasive and would greatly benefit human pollutant exposure research. We demonstrate the efficacy of exhaled breath collection and analysis in two human exposure studies to o...

journal_title：Journal of breath research

authors： Sawyer K,Samet JM,Ghio AJ,Pleil JD,Madden MC

更新日期：2008-09-01 00:00:00

abstract：:Leptin plays a key role in obstructive sleep apnea syndrome (OSAS). Leptin production in human airways has been previously evaluated by measuring leptin concentration in the exhaled breath condensate and in the induced sputum. The aim was to study leptin expression in the cells of induced sputum and in exhaled breath ...

journal_title：Journal of breath research

authors： Carpagnano GE,Resta O,Pergola GD,Sabato R,Foschino Barbaro MP

更新日期：2010-09-01 00:00:00

abstract：:Early detection of lung cancer (LC) is a priority since LC is characterized by symptoms mimicking other respiratory conditions, but it remains the leading cause of oncological disease death. Properly trained dogs can perceive the volatile organic compounds (VOCs) related to cancer thanks to their acute sense of smell....

journal_title：Journal of breath research

authors： Mazzola SM,Pirrone F,Sedda G,Gasparri R,Romano R,Spaggiari L,Mariangela A

更新日期：2020-03-11 00:00:00

abstract：:Oxidative stress is associated with numerous health conditions and disorders, and aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in exhaled human breath. Few studies report breath aldehyde levels in human populations, and none claim participant numbers in the hundreds or more. F...

journal_title：Journal of breath research

authors： McCartney MM,Thompson CJ,Klein LR,Ngo JH,Seibel JD,Fabia F,Simms LA,Borras E,Young BS,Lara J,Turnlund MW,Nguyen AP,Kenyon NJ,Davis CE

更新日期：2020-07-21 00:00:00

abstract：:Based on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon...

journal_title：Journal of breath research

authors： Zhou Q,Li E,Wang Z,Gong Y,Wang C,Guo L,Li H

更新日期：2015-01-05 00:00:00

abstract：:Tongue coating (TC) mainly consists of protein mostly from exfoliated epithelial cells. Until now, to reduce TC accumulation, only mechanical measures have been available, and the procedure involves unpleasant side effects, such as gagging reflex or carcinogenesis related to mechanical stimulation. We expected that pr...

journal_title：Journal of breath research

authors： Nohno K,Yamaga T,Kaneko N,Miyazaki H

更新日期：2012-03-01 00:00:00

abstract：:Breath analysis represents a new frontier in medical diagnosis and a powerful tool for cancer biomarker discovery due to the recent development of analytical platforms for the detection and identification of human exhaled volatile compounds. Statistical and bioinformatic tools may represent an effective complement to ...

journal_title：Journal of breath research

authors： Martinez-Lozano Sinues P,Landoni E,Miceli R,Dibari VF,Dugo M,Agresti R,Tagliabue E,Cristoni S,Orlandi R

更新日期：2015-09-21 00:00:00

abstract：:Bronchiectasis, bronchiolectasis, and bronchiolisation of alveolar regions are salient features of idiopathic pulmonary fibrosis (IPF). We asked whether IPF was associated with physiological changes consistent with increases in the volume of conducting airways, and whether airway volume was related to the severity of ...

journal_title：Journal of breath research

authors： Plantier L,Debray MP,Estellat C,Flamant M,Roy C,Bancal C,Borie R,Israël-Biet D,Mal H,Crestani B,Delclaux C

更新日期：2016-02-01 00:00:00