Abstract：
:The three CD3 genes on human chromosome 11q23 encode proteins (gamma, delta and epsilon) which form part of the antigen receptor on T lymphocytes. All three genes are clustered within 50 kb and are activated approximately contemporaneously during the early stages of T cell ontogeny. In order to pinpoint potential regulatory sequences important for locus activation and tissue-specific gene expression, the chromatin structure of almost 90 kb of this region has been probed in five cell lines using the endonuclease pancreatic DNase I. A set of DNase I hypersensitive (HS) sites has been defined in T cell chromatin, five of which were strong and not found in non-T cells, with the exception of the erythroleukaemia cell line K562, in which three sites were weakly expressed, correlating with a low level of delta mRNA. The subset of five HS sites map close to the CD3 genes and lie in regions which contain elements of defined function: the gamma promoter; the delta promoter and its 3' enhancer; and the epsilon promoter and its 3' enhancer. Since no further major T cell-restricted HS sites lie within the 90kb of the CD3 locus analysed, these five regions may contain all the sequences important for CD3 gene expression.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Tunnacliffe Adoi
10.1093/nar/18.3.459subject
Has Abstractpub_date
1990-02-11 00:00:00pages
459-64issue
3eissn
0305-1048issn
1362-4962journal_volume
18pub_type
杂志文章abstract：:Multiple myeloma, the second most frequent hematologic tumor after lymphomas, is an incurable cancer. Recent sequencing efforts have identified the ribonuclease DIS3 as one of the most frequently mutated genes in this disease. DIS3 represents the catalytic subunit of the exosome, a macromolecular complex central to th...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkv387
更新日期：2015-05-26 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/18.10.2917
更新日期：1990-05-25 00:00:00
abstract：:The Saccharomyces cerevisiae kinase/adenosine triphosphatase Rio1 regulates rDNA transcription and segregation, pre-rRNA processing and small ribosomal subunit maturation. Other roles are unknown. When overexpressed, human ortholog RIOK1 drives tumor growth and metastasis. Likewise, RIOK1 promotes 40S ribosomal subuni...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gky618
更新日期：2018-09-06 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gki374
更新日期：2005-07-01 00:00:00
abstract：:Late SV40 16S and 19S mRNAs were found to contain an average of three m6A residues per mRNA molecule. The methylated residues of both the viral and cellular mRNAs occur in two sequences; Gpm6ApC and (Ap)nm6ApC, where n = 1-4. More than 60% of the m6A residues in SV40 16S and 19S mRNAs occur in Gpm6ApC even though ther...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/6.8.2879
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abstract：:The putative role of double-strand breaks (DSBs) created in vitro by restriction enzyme cleavage in or near CGG*CCG or CTG*CAG repeat tracts on their genetic instabilities, both within the repeats and in their flanking sequences, was investigated in an Escherichia coli plasmid system. DSBs at TRS junctions with the ve...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkl612
更新日期：2006-01-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/23.18.3704
更新日期：1995-09-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/21.23.5431
更新日期：1993-11-25 00:00:00
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pub_type： 杂志文章
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更新日期：1992-12-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：2017-10-13 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/19.19.5205
更新日期：1991-10-11 00:00:00
abstract：:A small library of 49 peptide-oligonucleotide conjugates were synthesized to explore the influence of various peptide side chains on the hybridization properties of the DNA. An invariant 8mer oligonucleotide was coupled to a peptide portion that contained a five residue variable region composed of the cationic amino a...
journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：1998-07-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
abstract：:High throughput sequencing (HTS) platforms generate unprecedented amounts of data that introduce challenges for processing and downstream analysis. While tools that report the 'best' mapping location of each read provide a fast way to process HTS data, they are not suitable for many types of downstream analysis such a...
journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gku370
更新日期：2014-07-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：1978-08-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/20.12.3233
更新日期：1992-06-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/gkt911
更新日期：2014-01-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：1975-03-01 00:00:00
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journal_title：Nucleic acids research
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pub_type： 杂志文章
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更新日期：1988-07-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：1988-05-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/30.5.1103
更新日期：2002-03-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/10.14.4279
更新日期：1982-07-24 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/18.24.7305
更新日期：1990-12-25 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Nucleic acids research
pub_type： 杂志文章
doi：10.1093/nar/22.1.94
更新日期：1994-01-11 00:00:00
abstract：:Upf1 is a highly conserved RNA helicase essential for nonsense-mediated mRNA decay (NMD), an mRNA quality-control mechanism that degrades aberrant mRNAs harboring premature termination codons (PTCs). For the activation of NMD, UPF1 interacts first with a translation-terminating ribosome and then with a downstream exon...
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pub_type： 杂志文章
doi：10.1093/nar/gks344
更新日期：2012-08-01 00:00:00
