Identification of microRNA-mRNA modules using microarray data.

abstract：BACKGROUND:Protein-protein interaction (PPI) maps are useful tools for investigating the cellular functions of genes. Thus far, large-scale PPI mapping projects have not been implemented for the rice blast fungus Magnaporthe grisea, which is responsible for the most severe rice disease. Inspired by recent advances in P...

journal_title：BMC genomics

authors： He F,Zhang Y,Chen H,Zhang Z,Peng YL

更新日期：2008-11-02 00:00:00

abstract：BACKGROUND:Aquaculture is the quickest growing sector in agriculture. However, QTL for important traits have been only identified in a few aquaculture species. We conducted QTL mapping for growth traits in an Asian seabass F(2) family with 359 individuals using 123 microsatellites and 22 SNPs, and performed association...

journal_title：BMC genomics

authors： Xia JH,Lin G,He X,Liu P,Liu F,Sun F,Tu R,Yue GH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The plastid acquisition by secondary endosymbiosis is a driving force for the algal evolution, and the comparative genomics was required to examine the genomic change of symbiont. Therefore, we established a pipeline of a de novo assembly of middle-sized genomes at a low cost and with high quality using long...

journal_title：BMC genomics

authors： Minei R,Hoshina R,Ogura A

更新日期：2018-09-24 00:00:00

abstract：BACKGROUND:RNA-seq and small RNA-seq are powerful, quantitative tools to study gene regulation and function. Common high-throughput sequencing methods rely on polymerase chain reaction (PCR) to expand the starting material, but not every molecule amplifies equally, causing some to be overrepresented. Unique molecular i...

journal_title：BMC genomics

authors： Fu Y,Wu PH,Beane T,Zamore PD,Weng Z

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain. RESULTS:We have used array comparative genomic hybridization (aCGH)...

journal_title：BMC genomics

authors： Maydan JS,Lorch A,Edgley ML,Flibotte S,Moerman DG

更新日期：2010-01-25 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs (miRNAs) have become a major therapeutic focus as their pervasive expression and powerful regulatory roles in disease pathogenesis become increasingly a...

journal_title：BMC genomics

authors： Kocerha J,Kouri N,Baker M,Finch N,DeJesus-Hernandez M,Gonzalez J,Chidamparam K,Josephs KA,Boeve BF,Graff-Radford NR,Crook J,Dickson DW,Rademakers R

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:The availability of fully sequenced genomes and the implementation of transcriptome technologies have increased the studies investigating the expression profiles for a variety of tissues, conditions, and species. In this study, using RNA-seq data for three distinct tissues (brain, liver, and muscle), we inve...

journal_title：BMC genomics

authors： Arhondakis S,Frousios K,Iliopoulos CS,Pissis SP,Tischler G,Kossida S

更新日期：2011-10-17 00:00:00

abstract：BACKGROUND:GLV-1h68 is an attenuated recombinant vaccinia virus (VACV) that selectively colonizes established human xenografts inducing their complete regression. RESULTS:Here, we explored xenograft/VACV/host interactions in vivo adopting organism-specific expression arrays and tumor cell/VACV in vitro comparing VACV ...

journal_title：BMC genomics

authors： Worschech A,Chen N,Yu YA,Zhang Q,Pos Z,Weibel S,Raab V,Sabatino M,Monaco A,Liu H,Monsurró V,Buller RM,Stroncek DF,Wang E,Szalay AA,Marincola FM

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:Several methods have recently been developed to identify regions of the genome that have been exposed to strong selection. However, recent theoretical and empirical work suggests that polygenic models are required to identify the genomic regions that are more moderately responding to ongoing selection on com...

journal_title：BMC genomics

authors： Decker JE,Vasco DA,McKay SD,McClure MC,Rolf MM,Kim J,Northcutt SL,Bauck S,Woodward BW,Schnabel RD,Taylor JF

更新日期：2012-11-09 00:00:00

abstract：BACKGROUND:5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate. The EPSPS genes of allohexaploid wheat (Triticum aestivum, AABBDD) have not been well characterized. Herein, the three homoeologous cop...

journal_title：BMC genomics

authors： Aramrak A,Kidwell KK,Steber CM,Burke IC

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...

journal_title：BMC genomics

authors： Dreisigacker S,Sharma RK,Huttner E,Karimov A,Obaidi MQ,Singh PK,Sansaloni C,Shrestha R,Sonder K,Braun HJ

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities. Recently the MLIV gene, MCOLN1, has been identified as a new member of the transient receptor potential (TRP) cation channel superfamily. Here we report the c...

journal_title：BMC genomics

authors： Falardeau JL,Kennedy JC,Acierno JS Jr,Sun M,Stahl S,Goldin E,Slaugenhaupt SA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Hulless barley, also called naked barley, is an important cereal crop worldwide, serving as a healthy food both for human consumption and animal feed. Nevertheless, it often suffered from drought stress during its growth and development, resulting in a drastic reduction in barley yields. Therefore, study on ...

journal_title：BMC genomics

authors： Zeng X,Bai L,Wei Z,Yuan H,Wang Y,Xu Q,Tang Y,Nyima T

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Improving fiber quality is a major challenge in cotton breeding, since the molecular basis of fiber quality traits is poorly understood. Fine mapping and candidate gene prediction of quantitative trait loci (QTL) controlling cotton fiber quality traits can help to elucidate the molecular basis of fiber quali...

journal_title：BMC genomics

authors： Liu D,Zhang J,Liu X,Wang W,Liu D,Teng Z,Fang X,Tan Z,Tang S,Yang J,Zhong J,Zhang Z

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:The domestic cat (Felis catus) is an important companion animal and is used as a large animal model for human disease. However, the comprehensive study of adaptive immunity in this species is hampered by the lack of data on lymphocyte antigen receptor genes and usage. The objectives of this study were to ann...

journal_title：BMC genomics

authors： Radtanakatikanon A,Keller SM,Darzentas N,Moore PF,Folch G,Nguefack Ngoune V,Lefranc MP,Vernau W

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Adaptive divergence driven by environmental heterogeneity has long been a fascinating topic in ecology and evolutionary biology. The study of the genetic basis of adaptive divergence has, however, been greatly hampered by a lack of genomic information. The recent development of transcriptome sequencing provi...

journal_title：BMC genomics

authors： Chu JH,Lin RC,Yeh CF,Hsu YC,Li SH

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:The steadily increasing number of prokaryotic genomes has accelerated the study of genome evolution; in particular, the availability of sets of genomes from closely related bacteria has facilitated the exploration of the mechanisms underlying genome plasticity. The family Vibrionaceae is found in the Gammapr...

journal_title：BMC genomics

authors： Gu J,Neary J,Cai H,Moshfeghian A,Rodriguez SA,Lilburn TG,Wang Y

更新日期：2009-07-07 00:00:00

abstract：BACKGROUND:The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal mode...

journal_title：BMC genomics

authors： Datson NA,Morsink MC,Atanasova S,Armstrong VW,Zischler H,Schlumbohm C,Dutilh BE,Huynen MA,Waegele B,Ruepp A,de Kloet ER,Fuchs E

更新日期：2007-06-25 00:00:00

abstract：BACKGROUND:With its genome sequence and other experimental attributes, Populus trichocarpa has become the model species for genomic studies of wood development. Wood is derived from secondary growth of tree stems, and begins with the development of a ring of vascular cambium in the young developing stem. The terminal r...

journal_title：BMC genomics

authors： Dharmawardhana P,Brunner AM,Strauss SH

更新日期：2010-03-04 00:00:00

abstract：BACKGROUND:Meiotic recombination is a fundamental evolutionary process. It not only generates diversity, but influences the efficacy of natural selection and genome evolution. There can be significant heterogeneity in recombination rates within and between species, however this variation is not well understood outside ...

journal_title：BMC genomics

authors： Gion JM,Hudson CJ,Lesur I,Vaillancourt RE,Potts BM,Freeman JS

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Clostridium botulinum is a diverse group of bacteria characterized by the production of botulinum neurotoxin. Botulinum neurotoxins are classified into serotypes (BoNT/A-G), which are produced by six species/Groups of Clostridia, but the genetic background of the bacteria remains poorly understood. The purpo...

journal_title：BMC genomics

authors： Williamson CH,Sahl JW,Smith TJ,Xie G,Foley BT,Smith LA,Fernández RA,Lindström M,Korkeala H,Keim P,Foster J,Hill K

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:Since 2007, bacterial canker caused by Pseudomonas syringae pv. actinidiae (Psa) has become a pandemic disease leading to important economic losses in every country where kiwifruit is widely cultivated. Options for controlling this disease are very limited and rely primarily on the use of bactericidal compou...

journal_title：BMC genomics

authors： Michelotti V,Lamontanara A,Buriani G,Orrù L,Cellini A,Donati I,Vanneste JL,Cattivelli L,Tacconi G,Spinelli F

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Nitrogen (N) is a key macronutrient required for plant growth and development. In this study, watermelon plants were grown under hydroponic conditions at 0.2 mM N, 4.5 mM N, and 9 mM N for 14 days. RESULTS:Dry weight and photosynthetic assimilation at low N (0.2 mM) was reduced by 29 and 74% compared with h...

journal_title：BMC genomics

authors： Nawaz MA,Chen C,Shireen F,Zheng Z,Sohail H,Afzal M,Ali MA,Bie Z,Huang Y

更新日期：2018-06-13 00:00:00

abstract：BACKGROUND:Rare genetic variation in the human population is a major source of pathophysiological variability and has been implicated in a host of complex phenotypes and diseases. Finding disease-related genes harboring disparate functional rare variants requires sequencing of many individuals across many genomic regio...

journal_title：BMC genomics

authors： Ramos E,Levinson BT,Chasnoff S,Hughes A,Young AL,Thornton K,Li A,Vallania FL,Province M,Druley TE

更新日期：2012-12-06 00:00:00

abstract：BACKGROUND:Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of the underlying mechanisms involved in generating metazoan diversity. However, the present functions of...

journal_title：BMC genomics

authors： Matsui T,Yamamoto T,Wyder S,Zdobnov EM,Kadowaki T

更新日期：2009-01-12 00:00:00

abstract：BACKGROUND:With the advance of new massively parallel genotyping technologies, quantitative trait loci (QTL) fine mapping and map-based cloning become more achievable in identifying genes for important and complex traits. Development of high-density genetic markers in the QTL regions of specific mapping populations is ...

journal_title：BMC genomics

authors： Wu X,Ren C,Joshi T,Vuong T,Xu D,Nguyen HT

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Root-knot nematodes are sedentary endoparasites that can infect more than 3000 plant species. Root-knot nematodes cause an estimated $100 billion annual loss worldwide. For successful establishment of the root-knot nematode in its host plant, it causes dramatic morphological and physiological changes in plan...

journal_title：BMC genomics

authors： Ibrahim HM,Hosseini P,Alkharouf NW,Hussein EH,Gamal El-Din Ael K,Aly MA,Matthews BF

更新日期：2011-05-10 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provide new inf...

journal_title：BMC genomics

authors： Calligaris R,Banica M,Roncaglia P,Robotti E,Finaurini S,Vlachouli C,Antonutti L,Iorio F,Carissimo A,Cattaruzza T,Ceiner A,Lazarevic D,Cucca A,Pangher N,Marengo E,di Bernardo D,Pizzolato G,Gustincich S

更新日期：2015-10-28 00:00:00

abstract：BACKGROUND:The response of the trout, O. mykiss, head kidney to bacterial lipopolysaccharide (LPS) or active and attenuated infectious hematopoietic necrosis virus (IHNV and attINHV respectively) intraperitoneal challenge, 24 and 72 hours post-injection, was investigated using a salmonid-specific cDNA microarray. RESU...

journal_title：BMC genomics

authors： MacKenzie S,Balasch JC,Novoa B,Ribas L,Roher N,Krasnov A,Figueras A

更新日期：2008-03-26 00:00:00

abstract：BACKGROUND:In biomedical research, gene expression profiling studies have been extensively conducted. The analysis of gene expression data has led to a deeper understanding of human genetics as well as practically useful models. Clustering analysis has been a critical component of gene expression data analysis and can ...

journal_title：BMC genomics

authors： Teran Hidalgo SJ,Wu M,Ma S

更新日期：2017-08-16 00:00:00