Abstract:
BACKGROUND:Close association between atrial fibrillation (AF) and brain natriuretic peptide (BNP) has been demonstrated by several studies. Important gender differences exist in AF patients including a higher plasma BNP level in women. Therefore, it is imperative to evaluate the relationship between AF and BNP separately in men and women. OBJECTIVE:This study examined possible gender-specific role of BNP in predicting procedure outcome in AF patients undergoing catheter ablation. METHOD:The study population included 568 consecutive patients (age 62 ± 10, male 73%, paroxysmal 25%, persistent 38%, and long-standing persistent AF 37%) undergoing AF ablation, who had structurally normal heart and left ventricular ejection fraction ≥45%. Baseline BNP was measured in all. Patients were grouped into "normal" and "high" BNP based on gender-specific cut-off values (<50 and ≥50 pg/mL in males, <100 and ≥ 100 pg/mL in females). RESULT:Baseline BNP was significantly higher among women than men (126 ± 112 versus 87 ± 99, P = 0.009). At 12 ± 6 month follow-up, 304 of 414 (73%) males and 98 of 154 (64%) females were AF/atrial tachycardia-free off antiarrhythmic drugs (log-rank P = 0.018). In multivariable analysis, BNP remained an independent predictor of AF recurrence (BNP ≥ 50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females (BNP ≥ 100: HR 0.79, 95% CI 0.43-1.42; P = 0.426). CONCLUSION:Baseline BNP was found to be an independent predictor of AF recurrence in male patients undergoing ablation. This correlation between BNP and AF recurrence was not observed in females. Thus, BNP plays a gender-specific prognostic role in AF.
journal_name
J Cardiovasc Electrophysioljournal_title
Journal of cardiovascular electrophysiologyauthors
Mohanty S,Mohanty P,Di Biase L,Rong B,Burkhardt D,Gallinghouse JG,Horton R,Sanchez JE,Bailey S,Zagrodzky J,Natale Adoi
10.1111/j.1540-8167.2011.02036.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
858-65issue
8eissn
1045-3873issn
1540-8167journal_volume
22pub_type
杂志文章abstract:BACKGROUND:Radiofrequency (RF) ablation for ventricular tachycardia (VT) has high failure rates. Whether endocavitary structures (ECS) such as the papillary muscles (PMs), moderator bands (MBs), or false tendons (FTs) impact VT ablation is unknown. METHODS AND RESULTS:We retrospectively reviewed records of 190 consecu...
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pub_type: 临床试验,杂志文章
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1540-8167.2007.01088.x
更新日期:2008-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1540-8167.2002.01240.x
更新日期:2002-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1111/j.1540-8167.2000.tb00744.x
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doi:10.1111/j.1540-8167.2005.00225.x
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journal_title:Journal of cardiovascular electrophysiology
pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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journal_title:Journal of cardiovascular electrophysiology
pub_type: 临床试验,杂志文章
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