Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens.

Abstract:

:Regulatory T cells (Treg) play critical roles in the modulation of immune responses to infectious agents. Further understanding of the factors that control Treg activation and expansion in response to pathogens is needed to manipulate Treg function in acute and chronic infections. Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of Foxp3(+) Treg that is dependent on retroviral superantigen (sag) genes encoded in the mouse genome. Sag-dependent Treg expansion was MHC class II dependent, CD4 independent, and required dendritic cells. Thus, one unique mechanism by which certain infectious agents evade host immune responses may be mediated by endogenous Sag-dependent activation and expansion of Treg.

authors

Punkosdy GA,Blain M,Glass DD,Lozano MM,O'Mara L,Dudley JP,Ahmed R,Shevach EM

doi

10.1073/pnas.1100213108

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

3677-82

issue

9

eissn

0027-8424

issn

1091-6490

pii

1100213108

journal_volume

108

pub_type

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