Abstract:
:Regulatory T cells (Treg) play critical roles in the modulation of immune responses to infectious agents. Further understanding of the factors that control Treg activation and expansion in response to pathogens is needed to manipulate Treg function in acute and chronic infections. Here we show that chronic, but not acute, infection of mice with lymphocytic choriomeningitis virus results in a marked expansion of Foxp3(+) Treg that is dependent on retroviral superantigen (sag) genes encoded in the mouse genome. Sag-dependent Treg expansion was MHC class II dependent, CD4 independent, and required dendritic cells. Thus, one unique mechanism by which certain infectious agents evade host immune responses may be mediated by endogenous Sag-dependent activation and expansion of Treg.
journal_name
Proc Natl Acad Sci U S Aauthors
Punkosdy GA,Blain M,Glass DD,Lozano MM,O'Mara L,Dudley JP,Ahmed R,Shevach EMdoi
10.1073/pnas.1100213108subject
Has Abstractpub_date
2011-03-01 00:00:00pages
3677-82issue
9eissn
0027-8424issn
1091-6490pii
1100213108journal_volume
108pub_type
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