Behavioral changes in 6-hydroxydopamine-treated rotation rats after delivery of various neuromodifying agents by means of a stereotactically implanted pellet to the brain.

Abstract:

:Small pellets loaded with apomorphine, thyrotropin-releasing hormone, and bromocriptine were implanted into the right striatum of 6-hydroxydopamine-treated rotation rats, and the efficacy of this drug delivery system was examined. Pellets containing neuromodifying agents, when implanted into the brain, may be just as effective as brain grafting in delivering various chemical agents to the brain. This method is much safer and simpler than brain grafting, since it bypasses many of the complicated problems associated with brain grafting. Application of this method to an animal experimental model for brain grafting and possibly in the treatment of parkinsonism should be considered along with brain grafting.

authors

Yoshida M,Torigoe R,Ohtsuru K,Kuramoto S

doi

10.1159/000100232

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

342-6

eissn

1011-6125

issn

1423-0372

journal_volume

54-55

pub_type

杂志文章
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