A cytoplasm-specific activity encoded by the Trithorax-like ATX1 gene.

Abstract:

:Eukaryotes produce multiple products from a single gene locus by alternative splicing, translation or promoter usage as mechanisms expanding the complexity of their proteome. Trithorax proteins, including the Arabidopsis Trithorax-like protein ATX1, are histone modifiers regulating gene activity. Here, we report that a novel member of the Trithorax family has a role unrelated to chromatin. It is encoded from an internal promoter in the ATX1 locus as an isoform containing only the SET domain (soloSET). It is located exclusively in the cytoplasm and its substrate is the elongation factor 1A (EF1A). Loss of SET, but not of the histone modifying ATX1-SET activity, affects cytoskeletal actin bundling illustrating that the two isoforms have distinct functions in Arabidopsis cells.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Ndamukong I,Lapko H,Cerny RL,Avramova Z

doi

10.1093/nar/gkq1300

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

4709-18

issue

11

eissn

0305-1048

issn

1362-4962

pii

gkq1300

journal_volume

39

pub_type

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