Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma.

abstract：BACKGROUND:When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. However, critical questions remain regarding the regulation of this developmental event. How do three dozen insulin-like proteins regulate one tyrosine kinase rece...

journal_title：BMC developmental biology

authors： Liu T,Zimmerman KK,Patterson GI

更新日期：2004-09-20 00:00:00

abstract：BACKGROUND:The regulation of proneural gene expression is an important aspect of neurogenesis. In the study of the Drosophila proneural genes, scute and atonal, several themes have emerged that contribute to our understanding of the mechanism of neurogenesis. First, spatial complexity in proneural expression results fr...

journal_title：BMC developmental biology

authors： Holohan EE,zur Lage PI,Jarman AP

更新日期：2006-11-09 00:00:00

abstract：BACKGROUND:Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Recently, genetic defects of this pathway have been described, that lead to Cr deficiency, ...

journal_title：BMC developmental biology

authors： Braissant O,Henry H,Villard AM,Speer O,Wallimann T,Bachmann C

更新日期：2005-05-26 00:00:00

abstract：BACKGROUND:The embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth...

journal_title：BMC developmental biology

authors： Wang K,Shen H,Gan P,Cavallero S,Kumar SR,Lien CL,Sucov HM

更新日期：2019-03-25 00:00:00

abstract：BACKGROUND:The neural tube is formed by morphogenetic movements largely dependent on cytoskeletal dynamics. Actin and many of its associated proteins have been proposed as important mediators of neurulation. For instance, mice deficient in MARCKS, an actin cross-linking membrane-associated protein that is regulated by ...

journal_title：BMC developmental biology

authors： Zolessi FR,Arruti C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Real-time quantitative PCR is a sensitive and very efficient technique to examine gene transcription patterns in preimplantation embryos, in order to gain information about embryo development and to optimize assisted reproductive technologies. Critical to the successful application of real-time PCR is carefu...

journal_title：BMC developmental biology

authors： Goossens K,Van Poucke M,Van Soom A,Vandesompele J,Van Zeveren A,Peelman LJ

更新日期：2005-12-03 00:00:00

abstract：BACKGROUND:One way in which positional information is established during embryonic development is through the graded distribution of diffusible morphogens. Unfortunately, little is known about how cells interpret different concentrations of morphogen to activate different genes or how thresholds are generated in a morp...

journal_title：BMC developmental biology

authors： Saka Y,Smith JC

更新日期：2007-05-16 00:00:00

abstract：BACKGROUND:Copines are calcium-dependent phospholipid-binding proteins found in diverse eukaryotic organisms. We are studying the function of copines in Dictyostelium discoideum, a single-celled amoeba that undergoes cell differentiation and morphogenesis to form multicellular fruiting bodies when placed in starvation ...

journal_title：BMC developmental biology

authors： Smith TS,Pineda JM,Donaghy AC,Damer CK

更新日期：2010-06-02 00:00:00

abstract：BACKGROUND:Mammals are not able to restore lost appendages, while many amphibians are. One important question about epimorphic regeneration is related to the origin of the new tissues and whether they come from mature cells via dedifferentiation and/or from stem cells. Several studies in urodele amphibians (salamanders...

journal_title：BMC developmental biology

authors： Rodrigues AM,Christen B,Martí M,Izpisúa Belmonte JC

更新日期：2012-02-27 00:00:00

abstract：BACKGROUND:The C. elegans gene folt-1 is an ortholog of the human reduced folate carrier gene. The FOLT-1 protein has been shown to transport folate and to be involved in uptake of exogenous folate by worms. A knockout mutation of the gene, folt-1(ok1460), was shown to cause sterility, and here we investigate the sourc...

journal_title：BMC developmental biology

authors： Austin MU,Liau WS,Balamurugan K,Ashokkumar B,Said HM,LaMunyon CW

更新日期：2010-05-04 00:00:00

abstract：BACKGROUND:Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the bl...

journal_title：BMC developmental biology

authors： Zolini AM,Negrón-Pérez VM,Hansen PJ

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:The DNA damage-mediated cell cycle checkpoint is an essential mechanism in the DNA damage response (DDR). During embryonic development, the characteristics of cell cycle and DNA damage checkpoint evolve from an extremely short G1 cell phase and lacking G1 checkpoint to lengthening G1 phase and the establishm...

journal_title：BMC developmental biology

authors： Wang XQ,Chan KK,Ming X,Lui VC,Poon RY,Lo CM,Norbury C,Poon RT

更新日期：2014-05-19 00:00:00

abstract：BACKGROUND:Fertilization in Caenorhabditis elegans requires functional SPE-9 protein in sperm. SPE-9 is a transmembrane protein with a predicted extracellular domain that contains ten epidermal growth factor (EGF)-like motifs. The presence of these EGF-like motifs suggests that SPE-9 is likely to function in gamete adh...

journal_title：BMC developmental biology

authors： Zannoni S,L'Hernault SW,Singson AW

更新日期：2003-12-03 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) play important roles in glial cell development and in disease states within multiple regions of the central nervous system. However, little is known about HDAC expression or function within the optic nerve. As a first step in understanding the role of HDACs in optic nerve, this s...

journal_title：BMC developmental biology

authors： Tiwari S,Dharmarajan S,Shivanna M,Otteson DC,Belecky-Adams TL

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:The zinc finger transcription factor Egr-1 (Early growth response 1) is central to several growth factors and represents an important activator of target genes not only involved in physiological processes like embryogenesis and neonatal development, but also in a variety of pathophysiological processes, for ...

journal_title：BMC developmental biology

authors： Dussmann P,Pagel JI,Vogel S,Magnusson T,Zimmermann R,Wagner E,Schaper W,Ogris M,Deindl E

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Many insects undergo a period of arrested development, called diapause, to avoid seasonally recurring adverse conditions. Whilst the phenology and endocrinology of insect diapause have been well studied, there has been comparatively little research into the developmental details of diapause. We investigated ...

journal_title：BMC developmental biology

authors： Shingleton AW,Sisk GC,Stern DL

更新日期：2003-08-08 00:00:00

abstract：BACKGROUND:Studies of gene function in the mouse have relied mainly on gene targeting via homologous recombination. However, this approach is difficult to apply in specific windows of time, and to simultaneously knock-down multiple genes. Here we report an efficient method for dsRNA-mediated gene silencing in late clea...

journal_title：BMC developmental biology

authors： Soares ML,Haraguchi S,Torres-Padilla ME,Kalmar T,Carpenter L,Bell G,Morrison A,Ring CJ,Clarke NJ,Glover DM,Zernicka-Goetz M

更新日期：2005-12-28 00:00:00

abstract：BACKGROUND:ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear. RESULTS:To help determine the function of ERK5 we have used gene targeting to inactivate this gene in mice. Here we report that ERK5 ...

journal_title：BMC developmental biology

authors： Yan L,Carr J,Ashby PR,Murry-Tait V,Thompson C,Arthur JS

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:While the body axis is largely patterned along the anterior-posterior (A-P) axis during gastrulation, the central nervous system (CNS) shows dynamic changes in the expression pattern of Hox genes during neurulation, suggesting that the CNS refines the A-P pattern continuously after neural tube formation. Thi...

journal_title：BMC developmental biology

authors： Amirthalingam GS,Howard S,Alvarez S,de Lera AR,Itasaki N

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, inflammation and endothelial tubulogenesis. Despite over a decade of research, no comprehensive in situ ...

journal_title：BMC developmental biology

authors： Padmakumar V,Masiuk KE,Luger D,Lee C,Coppola V,Tessarollo L,Hoover SB,Karavanova I,Buonanno A,Simpson RM,Yuspa SH

更新日期：2014-05-28 00:00:00

abstract：BACKGROUND:The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF)...

journal_title：BMC developmental biology

authors： Hirose K,Shiomi T,Hozumi S,Kikuchi Y

更新日期：2014-12-06 00:00:00

abstract：BACKGROUND:Somitogenesis is the earliest sign of segmentation in the developing vertebrate embryo. This process starts very early, soon after gastrulation has initiated and proceeds in an anterior-to-posterior direction during body axis elongation. It is widely accepted that somitogenesis is controlled by a molecular o...

journal_title：BMC developmental biology

authors： Tenin G,Wright D,Ferjentsik Z,Bone R,McGrew MJ,Maroto M

更新日期：2010-02-25 00:00:00

abstract：BACKGROUND:Super-resolution fluorescence microscopy performed via 3D structured illumination microscopy (3D-SIM) is well established on flat, adherent cells. However, blastomeres of mammalian embryos are non-adherent, round and large. Scanning whole mount mammalian embryos with 3D-SIM is prone to failure due to the mov...

journal_title：BMC developmental biology

authors： Popken J,Dahlhoff M,Guengoer T,Wolf E,Zakhartchenko V

更新日期：2015-11-26 00:00:00

abstract：BACKGROUND:The nematode Caenorhabditis elegans has emerged as a powerful system to study biologic questions ranging from development to aging. The generation of transgenic animals is an important experimental tool and allows use of GFP fusion proteins to study the expression of genes of interest or generation of epitop...

journal_title：BMC developmental biology

authors： Zhang Y,Nash L,Fisher AL

更新日期：2008-12-30 00:00:00

abstract：BACKGROUND:Normal growth and development of organisms requires maintenance of a dynamic balance between systems that promote cell survival and those that induce apoptosis. The molecular mechanisms that regulate these processes remain poorly understood, and thus further in vivo study is required. Survivin is a member of...

journal_title：BMC developmental biology

authors： Delvaeye M,De Vriese A,Zwerts F,Betz I,Moons M,Autiero M,Conway EM

更新日期：2009-03-26 00:00:00

abstract：BACKGROUND:Formation of haploid spermatozoa capable of fertilization requires proper programming of epigenetic information. Exactly how DNMT3L (DNA methyltransferase 3-Like), a postulated regulator of DNA methyltransferase activity, contributes to DNA methylation pattern acquisition during gametogenesis remains unclear...

journal_title：BMC developmental biology

authors： La Salle S,Oakes CC,Neaga OR,Bourc'his D,Bestor TH,Trasler JM

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Establishment of the left-right axis is important for positioning organs asymmetrically in the developing vertebrate-embryo. A number of factors like maternally deposited molecules have emerged essential in initiating the specification of the axis; the downstream events, however, are regulated by signal-tran...

journal_title：BMC developmental biology

authors： Gupta K,Pilli VS,Aradhyam GK

更新日期：2016-10-28 00:00:00

abstract：BACKGROUND:Bats comprise the second largest order of mammals. However, there are far fewer morphological studies of post-implantation embryonic development than early embryonic development in bats. RESULTS:We studied three species of bats (Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. pratti), repr...

journal_title：BMC developmental biology

authors： Wang Z,Han N,Racey PA,Ru B,He G

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there has been very limited research on the effects of NO on metamorphosis in bivalve shellfish. RESULTS:...

journal_title：BMC developmental biology

authors： Vogeler S,Carboni S,Li X,Nevejan N,Monaghan SJ,Ireland JH,Joyce A

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Changes in transcellular bioelectrical patterns are known to play important roles during developmental and regenerative processes. The Drosophila follicular epithelium has proven to be an appropriate model system for studying the mechanisms by which bioelectrical signals emerge and act. Fluorescent indicator...

journal_title：BMC developmental biology

authors： Schotthöfer SK,Bohrmann J

更新日期：2020-07-08 00:00:00