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Tick saliva regulates migration, phagocytosis, and gene expression in the macrophage-like cell line, IC-21.

Abstract：

:We studied the effects of tick saliva on cell migration, cell signaling, phagocytosis, and gene expression in the murine macrophage cell line, IC-21. Saliva increased both basal- and platelet-derived growth factor (PDGF)-stimulated migration in IC-21 cells. However, saliva did not affect PDGF-stimulated extracellular signal-regulated kinase (ERK) activity. Zymosan-mediated interleukin-1 receptor associated kinase (IRAK) activity increased when cells were pretreated with saliva. Saliva suppressed phagocytosis of zymosan particles by IC-21 cells. An RT(2) Profiler™ PCR Array revealed that saliva regulates gene expression in a manner consistent with an immune response skewed toward a Th2 reaction, which is characterized by production of anti-inflammatory cytokines IL-4 and IL-10. Our results using IC-21 cells suggest that Dermacentor variabilis has evolved a mechanism for regulating macrophage function, which may contribute to the tick's ability to modulate immune function.

journal_name

Exp Parasitol

journal_title

Experimental parasitology

authors

Kramer CD,Poole NM,Coons LB,Cole JA

doi

10.1016/j.exppara.2010.11.012

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

665-71

issue

3

eissn

0014-4894

issn

1090-2449

pii

S0014-4894(10)00353-X

journal_volume

127

pub_type

杂志文章

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