Advances in melanoma senescence and potential clinical application.

Abstract:

:Normal cells possess a limited proliferative life span, after which they enter a state of irreversible growth arrest, called replicative senescence, which acts as a potent barrier against transformation. Transformed cells have escaped the process of replicative senescence and theoretically can not re-enter senescence. However, recent observations showed that transformed cells, and particularly the melanoma cells, can still undergo oncogene or stress-induced senescence. This senescence state is accompanied by many of the markers associated with replicative senescence, such as flattened shape, increased acidic β-galactosidase activity, characteristic changes in gene expression and growth arrest. Interestingly, in some cancers, senescence induction following chemotherapy has been correlated with a favorable patient outcome. In this review, we gathered recent results describing senescence-like phenotype induction in melanoma cells and discuss why senescence may also be exploited as a therapeutic strategy in melanoma.

authors

Giuliano S,Ohanna M,Ballotti R,Bertolotto C

doi

10.1111/j.1755-148X.2010.00820.x

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

295-308

issue

2

eissn

1755-1471

issn

1755-148X

journal_volume

24

pub_type

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