Cardiac allograft vasculopathy: advances in diagnosis.

Abstract:

:Cardiac allograft vasculopathy (CAV), characterized by diffuse intimal thickening and luminal narrowing in the arteries of the allograft, is the leading cause of morbidity and mortality in cardiac transplant recipients. Many transplant centers perform routine annual surveillance coronary angiography. However, angiography can underdiagnose or miss CAV due to its diffuse nature. Intravascular ultrasound (IVUS) is more sensitive than angiography. IVUS provides not only accurate information on lumen size, but also quantification of intimal thickening, vessel wall morphology, and composition. IVUS has evolved as a valuable adjunct to angiography and the optimal diagnostic tool for early detection. Noninvasive testing such as dobutamine stress echocardiography and nuclear stress test have shown considerable accuracy in diagnosing significant CAV. Computed tomographic imaging and cardiac magnetic resonance imaging are promising new modalities but require further study. This article reviews the diagnostic methods that are currently available.

journal_name

Cardiol Rev

journal_title

Cardiology in review

authors

Cai Q,Rangasetty UC,Barbagelata A,Fujise K,Koerner MM

doi

10.1097/CRD.0b013e3181fbde2f

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

30-5

issue

1

eissn

1061-5377

issn

1538-4683

pii

00045415-201101000-00006

journal_volume

19

pub_type

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