Abstract:
:The possible physiological role of a putative testicular gonadotropin-releasing hormone (GnRH)-like material was studied in the frog, Rana esculenta. We have investigated (a) changes of mitotic index (MI) of primary spermatogonia (SPG) in GnRH agonist (GnRH-Ag)-treated testes in vitro; (b) changes of androgen concentrations in testes of intact frogs treated with a GnRH antagonist (GnRH-Ant); (c) variations of mitotic index of primary SPG in intact GnRH-Ant-injected animals and in testes incubated with GnRH-Ant; (d) changes of MI in hypophysectomized (PDX) animals treated with hypophysis (PD) homogenate, and hCG alone or in combination with GnRH-Ant; and (e) changes of androgen concentrations in plasma PDX frogs treated with hCG and hCG plus GnRH-Ant. Our results indicate that while GnRH-Ag induced accumulation of primary SPG mitosis, GnRH-Ant inhibited androgen production and natural occurring mitosis accumulation. Therefore, GnRH-Ant may counteract an endogenous peptide working into the testis.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Di Matteo L,Minucci S,Fasano S,D'Antonio M,Pierantoni R,Chieffi Gdoi
10.1016/0016-6480(90)90098-7subject
Has Abstractpub_date
1990-07-01 00:00:00pages
147-53issue
1eissn
0016-6480issn
1095-6840journal_volume
79pub_type
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