N-terminal RASSF family: RASSF7-RASSF10.

abstract：:The epigenetic alteration of aberrant hypermethylation in the promoter CpG island of a gene is associated with repression of transcription. In neoplastic cells, aberrant hypermethylation is well described as a mechanism of allele inactivation of particular genes with a tumor suppressor function. To investigate the rol...

journal_title：Epigenetics

authors： Ibragimova I,Dulaimi E,Slifker MJ,Chen DY,Uzzo RG,Cairns P

更新日期：2014-05-01 00:00:00

abstract：:D-glucuronyl C5-epimerase (GLCE) is a potential tumor-suppressor gene involved in heparan sulfate biosynthesis. GLCE expression is significantly decreased in breast tumors; however, the underlying molecular mechanisms remain unclear. This study examined the possible epigenetic mechanisms for GLCE inactivation in breas...

journal_title：Epigenetics

authors： Mostovich LA,Prudnikova TY,Kondratov AG,Gubanova NV,Kharchenko OA,Kutsenko OS,Vavilov PV,Haraldson K,Kashuba VI,Ernberg I,Zabarovsky ER,Grigorieva EV

更新日期：2012-08-01 00:00:00

abstract：:DNA molecules are highly compacted in the eukaryotic nucleus where distal regulatory elements reach their targets through three-dimensional chromosomal interactions. G-quadruplexes, stable four-stranded non-canonical DNA structures, can change local chromatin organization through the exclusion of nucleosomes. However,...

journal_title：Epigenetics

authors： Hou Y,Li F,Zhang R,Li S,Liu H,Qin ZS,Sun X

更新日期：2019-09-01 00:00:00

abstract：:Puberty is a developmentally plastic phase. Variations in pubertal tempo have implications for the risk of later adult diseases. Influences on pubertal tempo have been widely discussed, but the underlying biological mechanisms remain unclear. Epigenetic modifications are known to regulate development processes; they c...

journal_title：Epigenetics

authors： Wu Y,Peterson KE,Sánchez BN,Dolinoy DC,Mercado-Garcia A,Téllez-Rojo MM,Goodrich JM

更新日期：2018-01-01 00:00:00

abstract：:Exposure to stress or glucocorticoids (GCs) is associated with epigenetic and transcriptional changes in genes that either mediate or are targets of GC signalling. FKBP5 (FK506 binding protein 5) is one such gene that also plays a central role in negative feedback regulation of GC signalling and several stress-related...

journal_title：Epigenetics

authors： Cox OH,Song HY,Garrison-Desany HM,Gadiwalla N,Carey JL,Menzies J,Lee RS

更新日期：2021-01-12 00:00:00

abstract：:While previous studies have demonstrated that prenatal exposure to environmental stressors is associated with mitochondrial DNA (mtDNA) methylation, more recent investigations are questioning the accuracy of the methylation assessment and its biological relevance. In this study, we investigated placental mtDNA methyla...

journal_title：Epigenetics

authors： Vos S,Nawrot TS,Martens DS,Byun HM,Janssen BG

更新日期：2020-07-11 00:00:00

abstract：:Risk for adverse neonatal outcome increases with declining gestational age (GA), and changes in DNA methylation may contribute to the relationship between GA and adverse health outcomes in offspring. To test this hypothesis, we evaluated the association between GA and more than 27,000 CpG sites in neonatal DNA extract...

journal_title：Epigenetics

authors： Schroeder JW,Conneely KN,Cubells JC,Kilaru V,Newport DJ,Knight BT,Stowe ZN,Brennan PA,Krushkal J,Tylavsky FA,Taylor RN,Adkins RM,Smith AK

更新日期：2011-12-01 00:00:00

abstract：:Cadmium (Cd) is prevalent in the environment yet understudied as a developmental toxicant. Cd partially crosses the placental barrier from mother to fetus and is linked to detrimental effects in newborns. Here we examine the relationship between levels of Cd during pregnancy and 5-methylcytosine (5mC) levels in leukoc...

journal_title：Epigenetics

authors： Sanders AP,Smeester L,Rojas D,DeBussycher T,Wu MC,Wright FA,Zhou YH,Laine JE,Rager JE,Swamy GK,Ashley-Koch A,Lynn Miranda M,Fry RC

更新日期：2014-02-01 00:00:00

abstract：:Previous studies have uncovered several transcription factors that determine biological alterations in tumor cells to execute the invasion-metastasis cascade, including the epithelial-mesenchymal transition (EMT). We sought to investigate the role of miR-21 in colorectal cancer regulation. For this purpose, miR-21 exp...

journal_title：Epigenetics

authors： Ferraro A,Kontos CK,Boni T,Bantounas I,Siakouli D,Kosmidou V,Vlassi M,Spyridakis Y,Tsipras I,Zografos G,Pintzas A

更新日期：2014-01-01 00:00:00

abstract：:Maintenance of ordered chromatin structure over the body of genes is vital for the regulation of transcription. Increased access to the underlying DNA sequence results in the recruitment of RNA polymerase II to inappropriate, promoter-like sites within genes, resulting in unfettered transcription. Two new papers show ...

journal_title：Epigenetics

authors： Smolle M,Workman JL,Venkatesh S

更新日期：2013-01-01 00:00:00

abstract：:During mouse development, imprinted X chromosome inactivation (XCI) is observed in preimplantation embryos and is inherited to the placental lineage, whereas random XCI is initiated in the embryonic proper. Xist RNA, which triggers XCI, is expressed ectopically in cloned embryos produced by somatic cell nuclear transf...

journal_title：Epigenetics

authors： Oikawa M,Inoue K,Shiura H,Matoba S,Kamimura S,Hirose M,Mekada K,Yoshiki A,Tanaka S,Abe K,Ishino F,Ogura A

更新日期：2014-02-01 00:00:00

abstract：:Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronchial epithelial BEAS-2B cells using the Illumina HumanMethylation450 ...

journal_title：Epigenetics

authors： Heßelbach K,Kim GJ,Flemming S,Häupl T,Bonin M,Dornhof R,Günther S,Merfort I,Humar M

更新日期：2017-09-01 00:00:00

abstract：:ATRX is a SWI/SNF chromatin remodeler proposed to govern genomic stability through the regulation of repetitive sequences, such as rDNA, retrotransposons, and pericentromeric and telomeric repeats. However, few direct ATRX target genes have been identified and high-throughput genomic approaches are currently lacking f...

journal_title：Epigenetics

authors： Valle-García D,Qadeer ZA,McHugh DS,Ghiraldini FG,Chowdhury AH,Hasson D,Dyer MA,Recillas-Targa F,Bernstein E

更新日期：2016-06-02 00:00:00

abstract：:DNA methylation is a widely studied epigenetic mechanism and alterations in methylation patterns may be involved in the development of common diseases. Unlike inherited changes in genetic sequence, variation in site-specific methylation varies by tissue, developmental stage, and disease status, and may be impacted by ...

journal_title：Epigenetics

authors： Wu C,Demerath EW,Pankow JS,Bressler J,Fornage M,Grove ML,Chen W,Guan W

更新日期：2016-01-01 00:00:00

abstract：:DNA methylation in post-mitotic neurons is reported to serve a variety of functions from survival during development to the consolidation of memory. Of particular interest with regards neuronal functioning is the change in site-specific methylation of a variety of gene promoters in the context of neuronal depolarizati...

journal_title：Epigenetics

authors： Sharma RP,Tun N,Grayson DR

更新日期：2008-03-01 00:00:00

abstract：:Epigenetic alterations related to prenatal neurotoxic metals exposure may be key in understanding the origins of cognitive and neurobehavioral problems in children. Placental glucocorticoid receptor (NR3C1) methylation has been linked to neurobehavioral risk in early life, but has not been examined in response to neur...

journal_title：Epigenetics

authors： Appleton AA,Jackson BP,Karagas M,Marsit CJ

更新日期：2017-08-01 00:00:00

abstract：:Through epigenetic modifications, specific long-term phenotypic consequences can arise from environmental influence on slowly evolving genomic DNA. Heritable epigenetic information regulates nucleosomal arrangement around DNA and determines patterns of gene silencing or active transcription. One of the greatest challe...

journal_title：Epigenetics

authors： Mazzio EA,Soliman KF

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Epigenetic markers are often quantified and related to disease in stored samples. While, effects of storage on stability of these markers have not been thoroughly examined. In this longitudinal study, we investigated the influence of storage time, material, temperature, and freeze-thaw cycles on stability of...

journal_title：Epigenetics

authors： Gosselt HR,Griffioen PH,van Zelst BD,Oosterom N,de Jonge R,Heil SG

更新日期：2020-07-02 00:00:00

abstract：:In recent years, a major breakthrough in the study of epigenetic silencing in eukaryotes came with the discovery that the RNA-interference pathway (RNAi) is generally implicated in heterochromatin assembly and gene silencing. An important and paradoxical feature of the RNAi-mediated heterochromatin pathways is their r...

journal_title：Epigenetics

authors： Lahmy S,Bies-Etheve N,Lagrange T

更新日期：2010-01-01 00:00:00

abstract：:Histone posttranslational modifications control the organization and function of chromatin. In particular, methylation of lysine 36 in histone H3 (H3K36me) has been shown to mediate gene transcription, DNA repair, cell cycle regulation, and pre-mRNA splicing. Notably, mutations at or near this residue have been causal...

journal_title：Epigenetics

authors： Klein BJ,Krajewski K,Restrepo S,Lewis PW,Strahl BD,Kutateladze TG

更新日期：2018-01-01 00:00:00

abstract：:TAL1/SCL (hereafter referred to as TAL1) is a critical transcription factor required for hematopoiesis in which hematopoietic stem cells commit and differentiate to different lineages. During this process, transcription of many genes is turned on and off in part by epigenetic mechanisms. TAL1 has recently been shown t...

journal_title：Epigenetics

authors： Hu X,Ybarra R,Qiu Y,Bungert J,Huang S

更新日期：2009-08-16 00:00:00

abstract：:Progression of cells through distinct phases of the cell cycle, and transition into out-of-cycling states, such as terminal differentiation and senescence, is accompanied by specific patterns of gene expression. These cell fate decisions are mediated not only by distinct transcription factors, but also chromatin modif...

journal_title：Epigenetics

authors： Rao VK,Pal A,Taneja R

更新日期：2017-03-04 00:00:00

abstract：:Chromatin is broadly compartmentalized in two defined states: euchromatin and heterochromatin. Generally, euchromatin is trimethylated on histone H3 lysine 4 (H3K4(me3)) while heterochromatin contains the H3K9(me3) marks. The H3K9(me3) modification is added by lysine methyltransferases (KMTs) such as SETDB1. Herein, w...

journal_title：Epigenetics

authors： Binda O,LeRoy G,Bua DJ,Garcia BA,Gozani O,Richard S

更新日期：2010-11-01 00:00:00

abstract：:Recently a mouse model of T/natural killer acute lymphoblastic leukemia was used to assess global promoter methylation across the mouse genome using the restriction landmark genomic scanning technique. One of the methylated mouse genes identified in this way was Slit2. There are three mammalian SLIT genes (SLIT1, SLIT...

journal_title：Epigenetics

authors： Dunwell TL,Dickinson RE,Stankovic T,Dallol A,Weston V,Austen B,Catchpoole D,Maher ER,Latif F

更新日期：2009-05-16 00:00:00

abstract：:Congenital heart defects represent the most common malformation at birth, occurring also in ∼50% of individuals with Down syndrome. Congenital heart defects are thought to have multifactorial etiology, but the main causes are largely unknown. We have explored the global methylation profile of fetal heart DNA in compar...

journal_title：Epigenetics

authors： Serra-Juhé C,Cuscó I,Homs A,Flores R,Torán N,Pérez-Jurado LA

更新日期：2015-01-01 00:00:00

abstract：:Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms. ...

journal_title：Epigenetics

authors： Yu Q

更新日期：2008-11-01 00:00:00

abstract：:Hypermethylation of the promoter region of tumor-related genes (TRGs) has been shown to silence gene expression during melanoma progression, whereas microRNA-29(miR-29) has been found to downregulate DNA methyltransferases DNMT3A and DNMT3B which were shown as essential to the methylation of TRGs. We hypothesized that...

journal_title：Epigenetics

authors： Nguyen T,Kuo C,Nicholl MB,Sim MS,Turner RR,Morton DL,Hoon DS

更新日期：2011-03-01 00:00:00

abstract：:The cellular epigenetic landscape changes as pluripotent stem cells differentiate to somatic cells or when differentiated cells transform to a cancerous state. These epigenetic changes are commonly correlated with differences in gene expression. Whether active DNA replication is also associated with distinct chromatin...

journal_title：Epigenetics

authors： Li B,Su T,Ferrari R,Li JY,Kurdistani SK

更新日期：2014-02-01 00:00:00

abstract：:Apart from the conventional view of repressive promoter methylation, the DNA methyltransferase 1 (DNMT1) was recently described to modulate gene expression through a variety of interactions with diverse epigenetic key players. We here investigated the DNMT1-dependent transcriptional control of the homeobox transcripti...

journal_title：Epigenetics

authors： Symmank J,Bayer C,Reichard J,Pensold D,Zimmer-Bensch G

更新日期：2020-11-01 00:00:00

abstract：:In this work we demonstrate a novel method of methylation detection that utilises immunoaffinity to detect the presence of methylated DNA hybridised to a cDNA microarray. We use a monoclonal antibody specific to 5 methyl cytidine to detect the presence of 5 methyl cytosine in genomic DNA from human fibroblasts bearing...

journal_title：Epigenetics

authors： Kelkar A,Deobagkar D

更新日期：2009-08-16 00:00:00