Investigation of adipose tissues in Zucker rats using in vivo and ex vivo magnetic resonance spectroscopy.

abstract：:HMG-CoA reductase inhibitors (statins) are effective lipid-altering drugs for the treatment of dyslipidemia in patients with type 2 diabetes mellitus. We conducted a randomized, double-blind, placebo-controlled, crossover design trial to determine the effects of simvastatin, 80 mg/day, on plasma lipid and lipoprotein ...

journal_title：Journal of lipid research

authors： Myerson M,Ngai C,Jones J,Holleran S,Ramakrishnan R,Berglund L,Ginsberg HN

更新日期：2005-12-01 00:00:00

abstract：:A higher incidence of coronary artery disease is associated with a lower level of HDL-cholesterol. We searched for genetic loci influencing HDL-cholesterol in F2 mice from a cross between MRL/MpJ and SM/J mice. Quantitative trait loci (QTL) mapping revealed one significant HDL QTL (Apoa2 locus), four suggestive QTL on...

journal_title：Journal of lipid research

authors： Leduc MS,Blair RH,Verdugo RA,Tsaih SW,Walsh K,Churchill GA,Paigen B

更新日期：2012-06-01 00:00:00

abstract：:Ceramides play an essential role in modulating immune signaling pathways and proinflammatory cytokine production in response to infectious pathogens, stress stimuli, or chemotherapeutic drugs. In this study, we demonstrated that Aggregatibacter actinomycetemcomitans, the pathogen for aggressive periodontitis, induced ...

journal_title：Journal of lipid research

authors： Yu H,Valerio M,Bielawski J

更新日期：2013-01-01 00:00:00

abstract：:We analyzed Niemann-Pick type C disease 1 (NPC1) gene in 12 patients with Niemann-Pick type C disease by sequencing both cDNA obtained from fibroblasts and genomic DNA. All the patients were compound heterozygotes. We found 15 mutations, eight of which previously unreported. The comparison of cDNA and genomic DNA reve...

journal_title：Journal of lipid research

authors： Tarugi P,Ballarini G,Bembi B,Battisti C,Palmeri S,Panzani F,Di Leo E,Martini C,Federico A,Calandra S

更新日期：2002-11-01 00:00:00

abstract：:3alpha-Hydroxy-5-cholanoic acid (lithocholic acid) and some unidentified acids (one of them perhaps 3-hydroxy-cholest-5-en-26-oic acid) have been detected in the brains of guinea pigs afflicted with experimental "allergic" encephalomyelitis. None of the acids could be identified in comparable amounts of brain tissue f...

journal_title：Journal of lipid research

authors： Naqvi SH,Herndon BL,Kelley MT,Bleisch V,Aexel RT,Nicholas HJ

更新日期：1969-01-01 00:00:00

abstract：:Imidazole catalyzed acylations of lysolipids by acyl-CoAs in water at room temperature and at a pH close to neutrality. In the presence of oleoyl-CoA and either lysophosphatidylcholine, 1-palmitoyl-sn-glycero-3-phosphocholine (LPC); lysophosphatidylglycerol, monoacyl-sn-glycero-3-phosphoglycerol; lysophosphatidyl acid...

journal_title：Journal of lipid research

authors： Testet E,Akermoun M,Shimoji M,Cassagne C,Bessoule JJ

更新日期：2002-07-01 00:00:00

abstract：:The effects of eicosapentaenoic acid and oleic acid on lipid synthesis and secretion by HepG2 cells were examined to identify fatty acid specific changes in lipid metabolism that might indicate a basis for the hypolipidemic effect attributed to eicosapentaenoic acid and related n-3 fatty acids. Cellular glycerolipid s...

journal_title：Journal of lipid research

authors： Homan R,Grossman JE,Pownall HJ

更新日期：1991-02-01 00:00:00

abstract：:The effect of a single glucose feeding upon the net inflow and outflow transport of plasma free fatty acids (FFA) has been studied in 75 unanesthetized rats. The animals were fasted for 22 +/- 2 hr; then 50 rats were refed 2 ml of 50% glucose by gastric intubation. At 0, 10-15, and 30-35 min after glucose refeeding, t...

journal_title：Journal of lipid research

authors： Baker N,Rostami H

更新日期：1969-01-01 00:00:00

abstract：:The beta-oxidation of stearic acid and of alpha- and gamma-methyl isoprenoid-derived fatty acids (pristanic and tetramethylheptadecanoic acids, respectively) was investigated in normal skin fibroblasts and in fibroblasts from patients with inherited defects in peroxisomal biogenesis. Stearic acid beta-oxidation by nor...

journal_title：Journal of lipid research

authors： Singh H,Usher S,Johnson D,Poulos A

更新日期：1990-02-01 00:00:00

abstract：:Retinoic acid (RA), the active metabolite of vitamin A, is required for spermatogenesis and many other biological processes. RA formation requires irreversible oxidation of retinal to RA by aldehyde dehydrogenase enzymes of the 1A family (ALDH1A). While ALDH1A1, ALDH1A2, and ALDH1A3 all form RA, the expression pattern...

journal_title：Journal of lipid research

authors： Arnold SL,Kent T,Hogarth CA,Schlatt S,Prasad B,Haenisch M,Walsh T,Muller CH,Griswold MD,Amory JK,Isoherranen N

更新日期：2015-02-01 00:00:00

abstract：:LY295427, (3 alpha,4 alpha,5 alpha)-4-(2-propenylcholestan-3-ol), acts through an unknown mechanism to derepress the transcription of the low density lipoprotein (LDL) receptor in the presence of 25-hydroxycholesterol (25-OH chol). Preincubation with LY295427 in Chinese hamster ovary (CHO) cells increased uptake of 25...

journal_title：Journal of lipid research

authors： Bowling N,Matter WF,Gadski RA,McClure DB,Schreyer T,Dawson PA,Vlahos CJ

更新日期：1996-12-01 00:00:00

abstract：:Rat brain increases in weight after birth in three stages: (I) rapidly for the first 2 weeks, (II) at a lower rate from 2 to 5 weeks, and (III) at a still lower rate from 5 weeks to 5 months. During the succeeding period, designated IV, it maintains constant weight up to 1 year of age. Brain ganglioside content increa...

journal_title：Journal of lipid research

authors： Rosenberg A,Stern N

更新日期：1966-01-01 00:00:00

abstract：:A positive effect of all-trans retinoic acid (ATRA) on white adipose tissue (WAT) oxidative and thermogenic capacity has been described and linked to an in vivo fat-lowering effect of ATRA in mice. However, little is known about the effects of ATRA on mitochondria in white fat. Our objective has been to characterize t...

journal_title：Journal of lipid research

authors： Tourniaire F,Musinovic H,Gouranton E,Astier J,Marcotorchino J,Arreguin A,Bernot D,Palou A,Bonet ML,Ribot J,Landrier JF

更新日期：2015-06-01 00:00:00

abstract：:Two novel mutations of the low density lipoprotein (LDL)-receptor gene were found in two Italian familial hypercholesterolemia (FH)-heterozygotes. The first mutation was an 18 nucleotide duplication in exon 8 which is preceded by an A-->T transversion. The translation product of the mutant allele was predicted to be a...

journal_title：Journal of lipid research

authors： Patel DD,Lelli N,Garuti R,Li Volti S,Bertolini S,Knight BL,Calandra S

更新日期：1998-07-01 00:00:00

abstract：:In Refsum disease, disorders of peroxisome biogenesis, and rhizomelic chondrodysplasia punctata, pathological accumulation of phytanic acid results from impaired alpha-oxidation of this branched-chain fatty acid. Previous studies from this laboratory indicated that activation of phytanic acid to its CoA derivative pre...

journal_title：Journal of lipid research

authors： Watkins PA,Howard AE,Gould SJ,Avigan J,Mihalik SJ

更新日期：1996-11-01 00:00:00

abstract：:Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated with systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16 week double-blind parallel interven...

journal_title：Journal of lipid research

authors： Bendsen NT,Stender S,Szecsi PB,Pedersen SB,Basu S,Hellgren LI,Newman JW,Larsen TM,Haugaard SB,Astrup A

更新日期：2011-10-01 00:00:00

abstract：:Trihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived oxylipins with potential physiological relevance in inflammatory processes as well as in maintaining an intact skin barrier. Due to the high number of possible TriHOME isomers with only subtle differences in their physicochemical properties, the stereoc...

journal_title：Journal of lipid research

authors： Fuchs D,Hamberg M,Sköld CM,Wheelock ÅM,Wheelock CE

更新日期：2018-10-01 00:00:00

abstract：:Although the synthesis pathways of intracellular triacylglycerol (TAG) species have been well elucidated, assessment of the contribution of an individual pathway to TAG pools in different mammalian organs, particularly under pathophysiological conditions, is difficult, although not impossible. Herein, we developed and...

journal_title：Journal of lipid research

authors： Han RH,Wang M,Fang X,Han X

更新日期：2013-04-01 00:00:00

abstract：:The inverse relationship between plasma levels of high density lipoprotein (HDL) and coronary heart disease rates has suggested that HDL might influence body stores of cholesterol. Therefore, we have investigated potential relationships between the parameters of body cholesterol metabolism and the plasma levels of HDL...

journal_title：Journal of lipid research

authors： Blum CB,Dell RB,Palmer RH,Ramakrishnan R,Seplowitz AH,Goodman DS

更新日期：1985-09-01 00:00:00

abstract：:The rate-limiting step in the transit of dietary fat across the intestinal absorptive cell is its exit from the endoplasmic reticulum (ER) in a specialized ER-to-Golgi transport vesicle, the prechylomicron transport vesicle (PCTV). PCTV bud off from the ER membranes and have unique features; they are the largest ER-de...

journal_title：Journal of lipid research

authors： Siddiqi S,Siddiqi SA,Mansbach CM 2nd

更新日期：2010-05-01 00:00:00

abstract：:Previous studies have shown that antibodies to cubulin, a receptor on the yolk sac that binds high density lipoproteins (HDL) and cobalamin, induce fetal abnormalities. Mice with markedly low concentrations of plasma HDL-cholesterol (HDL-C) give birth to healthy pups, however. To establish whether maternal HDL-C has a...

journal_title：Journal of lipid research

authors： McConihay JA,Honkomp AM,Granholm NA,Woollett LA

更新日期：2000-03-01 00:00:00

abstract：:The in vivo total body cholesterol transport of homozygous apoE-deficient (-/-) and control (+/+) mice was evaluated by compartmental analysis of plasma cholesterol decay. Body cholesterol fractional catabolic rates of chow fed mutants were less (-/-, 0.17 +/- 0.02; +/+, 0.51 +/- 0.06 day-1) and body cholesterol conte...

journal_title：Journal of lipid research

authors： Quarfordt SH,Oswald B,Landis B,Xu HS,Zhang SH,Maeda N

更新日期：1995-06-01 00:00:00

abstract：:High plasma cholesterol levels are found in several metabolic disorders and their reductions are advocated to reduce the risk of atherosclerosis. A way to lower plasma lipids is to curtail lipoprotein production; however, this is associated with steatosis. We previously showed that microRNA (miR)-30c lowers diet-induc...

journal_title：Journal of lipid research

authors： Irani S,Iqbal J,Antoni WJ,Ijaz L,Hussain MM

更新日期：2018-01-01 00:00:00

abstract：:Our previous studies have demonstrated the activity of oncostatin M (OM) in stimulating the transcription of the human LDL receptor (LDLR) gene in HepG2 cells through a sterol-independent regulatory mechanism. The current studies were designed to determine whether this in vitro property of OM could be recapitulated in...

journal_title：Journal of lipid research

authors： Kong W,Abidi P,Kraemer FB,Jiang JD,Liu J

更新日期：2005-06-01 00:00:00

abstract：:The reversibility and regression of histological and biochemical findings in a mouse model of Gaucher disease (4L/PS-NA) was evaluated using a liver-enriched activator protein promoter control of a tetracycline-controlled transcriptional activation-responsive human acid beta-glucosidase (hGCase) transgenic system. 4L/...

journal_title：Journal of lipid research

authors： Sun Y,Quinn B,Xu YH,Leonova T,Witte DP,Grabowski GA

更新日期：2006-10-01 00:00:00

abstract：:A gas-liquid chromatographic-mass spectrometric method of determining the position of oxygen atoms on polyfunctional fatty acids has been explored. The method consists of reduction of keto, hydroperoxy, epoxy, and carboxylic acid groups with LiAlH(4) to the corresponding alcohols; trimethylsilylation with bis(trimethy...

journal_title：Journal of lipid research

authors： Esselman WJ,Clagett CO

更新日期：1969-03-01 00:00:00

abstract：:The metabolism of chenodeoxycholic acid by Pseudomonas sp. NCIB 10590 under strict anaerobic conditions was studied. A range of unsaturated acidic and neutral metabolites were isolated and identified. The major acidic product was chola-4,6-dien-3-one-24-oic acid whilst the major neutral product was androsta-4,6-dien-3...

journal_title：Journal of lipid research

authors： Owen RW,Hill MJ,Bilton RF

更新日期：1983-09-01 00:00:00

abstract：:In vitro studies show that docosahexaenoic acid (DHA) can be released from membrane phospholipid by Ca(2+)-independent phospholipase A(2) (iPLA(2)), Ca(2+)-independent plasmalogen PLA(2) or secretory PLA(2 (sPLA2)), but not by Ca(2+)-dependent cytosolic PLA(2) (cPLA2), which selectively releases arachidonic acid (AA)....

journal_title：Journal of lipid research

authors： Ramadan E,Rosa AO,Chang L,Chen M,Rapoport SI,Basselin M

更新日期：2010-08-01 00:00:00

abstract：:Lilly PCSK9 antibody LY3015014 (LY) is a monoclonal antibody (mAb) that neutralizes proprotein convertase subtilisin-kexin type 9 (PCSK9). LY decreases LDL cholesterol in monkeys and, unlike other PCSK9 mAbs, does not cause an accumulation of intact PCSK9 in serum. Comparing the epitope of LY with other clinically tes...

journal_title：Journal of lipid research

authors： Schroeder KM,Beyer TP,Hansen RJ,Han B,Pickard RT,Wroblewski VJ,Kowala MC,Eacho PI

更新日期：2015-11-01 00:00:00

abstract：:Clostridium absonum was shown to metabolize primary bile acids to give rise to both 7-oxo bile acids and 7 beta-hydroxy (urso) bile acids. At relatively low redox potential (Eh) values, high yields of urso bile acids were achieved (60-75%). If, however, the Eh value of the culture was allowed to rise above approximate...

journal_title：Journal of lipid research

authors： Sutherland JD,Macdonald IA

更新日期：1982-07-01 00:00:00