Abstract:
:The nervous system is a biological computer integrating the body's reflex and voluntary environmental interactions (behavior) with a relatively constant internal state (homeostasis)-- promoting survival of the individual and species. The wiring diagram of the nervous system's structural connectivity provides an obligatory foundational model for understanding functional localization at molecular, cellular, systems, and behavioral organization levels. This paper provides a high-level, downwardly extendible, conceptual framework--like a compass and map--for describing and exploring in neuroinformatics systems (such as our Brain Architecture Knowledge Management System) the structural architecture of the nervous system's basic wiring diagram. For this, the Foundational Model of Connectivity's universe of discourse is the structural architecture of nervous system connectivity in all animals at all resolutions, and the model includes two key elements--a set of basic principles and an internally consistent set of concepts (defined vocabulary of standard terms)--arranged in an explicitly defined schema (set of relationships between concepts) allowing automatic inferences. In addition, rules and procedures for creating and modifying the foundational model are considered. Controlled vocabularies with broad community support typically are managed by standing committees of experts that create and refine boundary conditions, and a set of rules that are available on the Web.
journal_name
Proc Natl Acad Sci U S Aauthors
Swanson LW,Bota Mdoi
10.1073/pnas.1015128107subject
Has Abstractpub_date
2010-11-30 00:00:00pages
20610-7issue
48eissn
0027-8424issn
1091-6490pii
1015128107journal_volume
107pub_type
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